Search Results - harlan+caldwell

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Conformation Dependent Anti-major Outer Membrane Protein (MOMP) Monoclonal Antibody BD5
A murine hybridoma expressing mAb BD3 was found to react with a conformationally dependent epitope on the chlamydial Major Outer Membrane Protein (MOMP), a primary target of neutralizing antibodies and vaccine development. The BD3 neutralized the in vitro infectivity of C. trachomatis serovars B, Ba, D, E, L2. It is useful for verifying the correct...
Published: 10/28/2024   |   Inventor(s): Harlan Caldwell
Keywords(s): Against, ANTIBODY, Anti-major, B, ba, BD5, Chlamydia, CONFORMATION, Correct, D, Dependent, e, Hybridoma, L2, Listed LPM Thalhammer-Reyero as of 4/15/2015, Mab, MEMBRANE, MOMP, monoclonal, OUTER, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protein, RM, SEROVARS, TRACHOMATIS, USEFUL, vaccines, Verifying, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
Chlamydial Vaccine Technologies
The National Institute of Allergy and Infectious Diseases has invented three chlamydial vaccine technologies, which have shown promising preclinical efficacy. Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection. If left untreated, chlamydia infection can lead to pelvic inflammatory disease and infertility. Chlamydia...
Published: 10/28/2024   |   Inventor(s): Laszlo Kari, Deborah Crane, Harlan Caldwell
Keywords(s): Against, Attenuated, -Attenuated, Bacterial strains, Blinding, Chlamydia, DA3XXX, DC4XXX, DCXXXX, DD1XXX, DDXXXX, DISEASES, Human, Immunogenic, Listed LPM Stansberry as of 4/15/2015, Live, Model, MULTIPLE, NON, Patent Category - Biotechnology, Plasmid-deficient, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, primate, Protective, RM, SAFE, Sexually, Strain, Trachoma, TRACHOMATIS, Transmitted, UBXXXX, Vaccine, VJXXXX, WIXXXX, WNXXXX
Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Research Materials, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics
Novel Vaccine for Prevention and Treatment of Chlamydia Infection
The invention provides novel vectors, attenuated pathogens, compositions, methods and kits for preventing and/or treating chlamydia infections. Chlamydia trachomatis is an obligate intracellular human pathogen with a unique biphasic developmental growth cycle. It's the etiological agent of trachoma, the world's leading cause of preventable blindness...
Published: 10/28/2024   |   Inventor(s): Harlan Caldwell
Keywords(s): Against, Attenuated, DCXXXX, DISEASES, DXXXXX, Live, MULTIPLE, Sexually, Transmitted, Vaccine, VJXXXX, WNXXXX, XKXXXX, YBXXXX, YCXXXX, YDXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Application > Vaccines, TherapeuticArea > Infectious Disease
Chlamydia Vaccine
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that colonizes and infects oculogenital mucosal surfaces. The organism exists as multiple serovariants that infect millions of people worldwide. Ocular infections cause trachoma, a chronic follicular conjunctivitis that results in scarring and blindness. The World Health Organization...
Published: 10/28/2024   |   Inventor(s): Deborah Crane, Harlan Caldwell
Keywords(s): Against, Blinding, Chlamydia, DA3XXX, DAXXXX, DC4XXX, DCXXXX, DDXXXX, DISEASES, DXXXXX, Sexually, Trachoma, Trachoma (Chlamydia trachomatis), TRACHOMATIS, Transmitted, UBXXXX, Vaccine
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Vaccines