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Search Results - ilayda+mcmillan
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Binding Between TREM2 and Heparan Sulfate Delineates the Role of Microglia in AD and Reveals Novel Treatment Strategies
Advantages: Discovered novel structural interactions between HS and TREM2, associated with neurodegeneration High-affinity binding: TREM2 specifically interacts with Heparan Sulfate (HS) modified with 6-O-sulfation and iduronic acid, enabling precise microglial modulation compared to broad-spectrum anti-inflammatory strategies Defined structural...
Published: 8/12/2025
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Inventor(s):
Lianchun Wang
,
Ilayda McMillan
Keywords(s):
Immunology
,
Neurodegenerative Diseases
,
Neuroscience
Category(s):
zzNeurodegenerative Diseases Treatment
,
Technology Classifications > Medical > Neuroscience
,
Technology Classifications > Medical > Therapeutics