Search Results - zzneurodegenerative+diseases+treatment

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M4 Foldamer Peptidomimetic: Targeting Amyloid-beta (Aβ) Aggregation to Restore Neuronal Function in Alzheimer’s Disease
Adantages Enhanced Blood-Brain Barrier (BBB) Penetration allows for efficient therapeutic targeting Superior serum stability enables a longer therapeutic window compared to conventional peptide therapeutics Multimodal therapeutic mechanism simultaneously addresses multiple pathological hallmarks of Alzheimer’s Disease (AD) Summary Alzheimer’s...
Published: 8/22/2025   |   Inventor(s): Jianfeng Cai, Heng Liu, Donghui Zhu, Firoz Akhter
Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases, Therapeutics
Category(s): zzNeurodegenerative Diseases Treatment, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
Binding Between TREM2 and Heparan Sulfate Delineates the Role of Microglia in AD and Reveals Novel Treatment Strategies
Advantages: Discovered novel structural interactions between HS and TREM2, associated with neurodegeneration High-affinity binding: TREM2 specifically interacts with Heparan Sulfate (HS) modified with 6-O-sulfation and iduronic acid, enabling precise microglial modulation compared to broad-spectrum anti-inflammatory strategies Defined structural...
Published: 8/12/2025   |   Inventor(s): Lianchun Wang, Ilayda McMillan
Keywords(s): Immunology, Neurodegenerative Diseases, Neuroscience
Category(s): zzNeurodegenerative Diseases Treatment, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics