Search Results - gene+silencing

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Inducible Activation Nucleic Acid Hybrid Switch for Conditional Generation of Oligonucleotides
Abstract: Gene therapy research has yielded FDA-approved treatments for an array of diseases. However, challenges facing nucleic-acid based therapeutics include non-specific delivery and degradation of the nanoparticles. NCI investigators have developed a solution to address these challenges in their novel nucleic-based therapy based on the conditional...
Published: 7/29/2024   |   Inventor(s): Bruce Shapiro, Paul Zakrevsky
Keywords(s): Conditional Activation, Functional RNA, Gene silencing, In Silico Design, Nanoparticle, Nucleic Acid Therapeutic, RNA, RNA Logic, Shapiro
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
siRNA Delivery Using Hexameric Tetrahedral RNA Nanostructures for Gene Silencing
Abstract: RNA interference (RNAi) is a biological response to double-stranded RNA that regulates expression of protein-coding genes and is a natural mechanism for gene silencing. Delivery of short, interfering RNA (siRNA) leads to RNAi of the targeted genes.  Researchers at the National Cancer Institute (NCI), in collaboration with researchers at the...
Published: 8/14/2024   |   Inventor(s): Bruce Shapiro, Paul Zakrevsky, Luc Jaeger
Keywords(s): Gene silencing, Nanoparticle, RNA, RNA interference, RNAi, Shapiro, SiRNA
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics
RNA/DNA Nanoparticles as Cancer Therapeutics
Abstract: The development of RNA-based nanostructures and their use in a variety of applications, including RNA interference (RNAi) and drug delivery, represents an emerging field of science, technology, and biomedicine.  RNA is a dynamic material because of its natural functionalities, its ability to fold into complex small structures, and its capacity...
Published: 8/13/2024   |   Inventor(s): Bruce Shapiro, Mathias Viard, Eckart Bindewald, Kirill Afonin, Lorena Parlea
Keywords(s): Gene silencing, nanobiology, RNAi, Shapiro
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology
Manipulating mRNA Decay Pathway to Regulate Gene Expression
Brief Description: The process of mRNA decay, such as the Staufen1 (STAU1)-mediated mRNA decay (SMD), is integral to the post transcriptional control of genes that have been shown to be involved in a number of diseases. Alu elements are the most prominent repeats in the human genome: they constitute more than 10% of the human genome....
Published: 10/28/2024   |   Inventor(s): Lynne Maquat, Chenguang Gong
Keywords(s): Gene Expression, Gene Silencing, RNA
Category(s): Therapeutic, Research Tools