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Search Results - lynne+maquat
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Method for the suppression of transcripts escaping from nonsense-mediated mRNA decay
Background One-third of inherited human diseases are caused by mutated mRNAs harboring premature termination codons (PTCs). Nonsense-mediated mRNA decay (NMD) is a critical cellular surveillance mechanism that recognizes and eliminates aberrant RNAs containing PTC. NMD plays an important role in cell cycle regulation, cell viability, and DNA damage...
Published: 10/28/2024
|
Inventor(s):
Lynne Maquat
,
Tatsuaki Kurosaki
Keywords(s):
Category(s):
Therapeutic
Manipulating mRNA Decay Pathway to Regulate Gene Expression
Brief Description: The process of mRNA decay, such as the Staufen1 (STAU1)-mediated mRNA decay (SMD), is integral to the post transcriptional control of genes that have been shown to be involved in a number of diseases. Alu elements are the most prominent repeats in the human genome: they constitute more than 10% of the human genome....
Published: 10/28/2024
|
Inventor(s):
Lynne Maquat
,
Chenguang Gong
Keywords(s):
Gene Expression
,
Gene Silencing
,
RNA
Category(s):
Therapeutic
,
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