Search Results - biosignature

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ErbB4 Inhibitors and Methods of Use
ErbB4 is a receptor tyrosine kinase member with roles in several key pathways associated with cell proliferation, death and differentiation. ErbB4 overexpression is associated with several types of cancers as well as psychiatric and cardiovascular disorders. Currently there are no drugs available for ErbB4-driven pathologies, or methods of identifying...
Published: 2/23/2023   |   Inventor(s): Fernanda Festa, Joshua LaBaer, Jin Park, Femina Rauf
Keywords(s): Biosignature, Cancer, Diagnostics, Genomics, Proteomics, Protein Kinase Inhibitors
Category(s): Pharmaceuticals, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools
High-resolution Flexible Neural Implant
Optogenetics uses light stimulation to control the excitation, inhibition, or signaling pathways of optically excitable cells and provides a powerful tool to diagnose and treat, as well as understand, numerous neurological and psychiatric diseases and disorders. Modified neurons can be activated or silenced by different light frequencies. However, the...
Published: 11/1/2023   |   Inventor(s): Joseph Smith, Barry O'Brien, Yong-Kyun Lee, Edward Bawolek, Jennifer Blain Christen, Michael Goryll, Jitendran "jit" Muthuswamy, George Kunnen, David Allee
Keywords(s): Biological Cell Monitoring, Biosignature, Bio-Technology, Flexible electronics, Optoelectronics, Optogenetics
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Medical Devices, Neurodegenerative Disease Technologies, Semiconductors, Materials & Processes
System to Interface with Targeted Neurons
Current neural interface and neuromodulation technologies lack the stability and specificity to target specific sensory or motor neurons within a nerve bundle. Emerging prosthetic devices for the central and peripheral nervous system require interfaces that can stimulate or sense targeted neurons with high discriminability to achieve very specific end-target...
Published: 11/1/2023   |   Inventor(s): Jitendran "jit" Muthuswamy, Sivakumar Palaniswamy
Keywords(s): Bioaugmentation, biomarker, Biosignature, Brain and Machine Interface, CNS Therapeutics, Cyber-Physical System, Diagnostics, Drug Delivery, Gene Delivery, Implantable, Medical Device, MEMS, Neural Prostheses, Neurostim and Neuromodulation, Prosthesis, PS-Bioengineering, Medical, Sensors
Category(s): Life Science (All LS Techs), Medical Devices
Glycan Nodes: Multiplexed Glycotransferase Surrogate Analysis for Detecting and Monitoring Cancer
Cancer biologists have known for decades that tumor cells display aberrant sugar polymer (glycan) structures. This means that if glycans can be analyzed in the right way(s), they should serve as excellent markers for the presence and progression of cancer. Altered activity of the enzymes that build glycans (glycotransferases, GTs) is the immediate upstream...
Published: 2/23/2023   |   Inventor(s): Chad Borges, Douglas Rehder
Keywords(s): Biosignature, Cancer, Detection, Glycans, Health Monitoring, Molecular Diagnostics, Personalized medicine
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs)
Biomarkers for Irritable Bowel Syndrome (IBS)
Approximately 9% of the general population will report the onset of Irritable Bowel Syndrome (IBS) over a one year period. Unfortunately, at present, there is no standard and reliable diagnostic test for IBS. IBS is currently diagnosed using symptomatic criteria, but because symptoms of IBS can overlap with other GI diseases, there is considerable uncertainty...
Published: 2/23/2023   |   Inventor(s): Todd Sandrin, Peter Jurutka
Keywords(s): Biosignature, Bio-Technology, Gene Expression, Genomics, Proteomics, MicroArray, Molecular Diagnostics
Category(s): Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Medical Diagnostics/Sensors