Search Results - immuno-oncology

5 Results Sort By:
­SELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYMPHOCYTES
­SELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYMPHOCYTES Researchers at Stanford University have developed a novel method for the treatment and prevention of cancer. The immune system is an integral part of the human body’s response to outside threats, including cancer. Specifically, cytotoxic CD8+ T cells have been...
Published: 9/24/2024   |   Inventor(s): Reece Akana
Keywords(s): Cancer, Immuno-Oncology, T-Cell Activation
Category(s): Technology Classifications > Biology
Fully Human Antibodies and Antibody Drug Conjugates Targeting CD276 (B7-H3) for the Treatment of Cancer
Abstract: Angiogenesis is the formation of new blood vessels from pre-existing blood vessels. Angiogenesis occurs during normal growth and development, where it is known as physiological angiogenesis, and during the growth of solid tumors, where it is known as pathological angiogenesis. CD276, also known as B7-H3, is a cell surface tumor endothelial...
Published: 5/22/2024   |   Inventor(s): Dimiter Dimitrov, Zhongyu Zhu, Brad St. Croix, Steven Seaman, Saurabh Saha, Xaioyan Zhang, Dean Welsch, Gary Decrescenzo
Keywords(s): Antibody Drug Conjugate (ADC), B7-H3, CANCER, CD276, Dimitrov, immuno-oncology, Immunotherapy, Monoclonal Antibody
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics
HLA-A*01:01 Restricted Human T Cell Receptor Recognizing the NRAS Q61K Hotspot Mutation
Abstract: Mutation of amino acid 61of the neuroblastoma rat sarcoma viral oncogene homologue (NRAS) is a known driver of oncogenesis in melanoma. Glutamine (Q) to lysine (K) mutation at this position of NRAS is prevalent in approximately 10% of all melanoma cases and associated with aggressive tumors and low patient survival. Therefore, Q61K mutated...
Published: 4/8/2024   |   Inventor(s): Paul Robbins, Steven Rosenberg, Gabriel Ivey, Almin Latani
Keywords(s): act, Adoptive Cell Transfer, HLA, Human Leukocyte Antigen, immuno-oncology, Immunotherapy, Neuroblastoma Rat Sarcoma Viral Oncogene, NRAS, Robbins, Rosenberg, T-Cell Receptor, TCR
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics, Collaboration Sought > Licensing
GENE THERAPY FOR IMMUNO-ONCOLOGY APPLICATIONS
GENE THERAPY FOR IMMUNO-ONCOLOGY APPLICATIONS Researchers at the Chan Zuckerberg Biohub and UCSF have developed viral gene therapy delivery systems for therapeutic immuno-oncology applications. Glioblastoma is the most common and deadliest primary malignant brain cancer with an overall median survival of 14.6 months. Therapies currently in use, and...
Published: 5/31/2023   |   Inventor(s): Nicole Paulk, Joseph DeRisi, David Raleigh
Keywords(s): Convection Enhanced Delivery, Gene Therapy, Glioblastoma, Immuno-Oncology, Interferon (IFN), Recombinant Adenoviral-Associated Virus (rAAV)
Category(s): Technology Classifications > Biology
A unique B-cell model system for transdifferentiation and human immune modulation
The cells, derived from a B-cell acute lymphoblastic leukemia cell line, can be easily converted into human macrophage-like cells with 100% efficiency in just few days, recapitulating human macrophage function and biology better and more conveniently than existing model systems. They can be used for basic research and drug development purposes in relation...
Published: 2/19/2019   |   Inventor(s): Thomas Graf, Francesca Rapino
Keywords(s): Autoimmune Diseases, Cardiovascular Diseases, Cell-based Assay, Immune / Inflammatory Diseases, Immuno-oncology, Infectious Diseases, Metabolic Diseases, Neurodegenerative Diseases, Oncology
Category(s): Therapeutics (Biologics & Compounds), Research Tools (cell lines, mice, kits, ABs, ...), Drug Targets & Mechanisms