Search Results - t-cell+activation

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3D Scaffold for T Cell Delivery and Suppression of Tregs for Solid Tumors (UCLA Case No. 2020-193)
SUMMARY: UCLA researchers in the Department of Bioengineering have developed a small and biodegradable implant that when placed adjacent to solid tumors, enhances immune response to cancer cells. BACKGROUND: The body’s immune system uses proteins called antibodies to train the immune response to foreign pathogens. This mechanism can combat...
Published: 12/3/2024   |   Inventor(s): Manish Butte
Keywords(s): cytokines, Drug Delivery, Immunotherapy, Nanoparticles, scaffolds, solid tumors, T-cell activation, t-cells
Category(s): Platforms > Drug Delivery > Nanoparticles
­SELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYMPHOCYTES
­SELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYMPHOCYTES Researchers at Stanford University have developed a novel method for the treatment and prevention of cancer. The immune system is an integral part of the human body’s response to outside threats, including cancer. Specifically, cytotoxic CD8+ T cells have been...
Published: 9/24/2024   |   Inventor(s): Reece Akana
Keywords(s): Cancer, Immuno-Oncology, T-Cell Activation
Category(s): Technology Classifications > Biology
Synthetic Viscoelastic Activating Cells (SynVACs) for T cell engineering (UCLA Case No. 2023-190)
UCLA researchers in the Department of Bioengineering have developed a novel microfluidic device that produces synthetic viscoelastic cells for efficacious therapeutic T cell activation. BACKGROUND: T cell-based therapies, such as the chimeric antigen receptor (CAR) T cell therapy, represents a significant advancement in cancer treatment, particularly...
Published: 11/15/2024   |   Inventor(s): Zeyang Liu, Song Li, Lili Yang, Yan-Ruide Li
Keywords(s): CAR-T cell therapy, Synthetic antigen presenting cells (SynVACs), T Cell, T cell based therapy, T-cell activation, T-cell engineering, t-cells
Category(s): Therapeutics > Oncology
BACTERIA-ENGINEERED TO ELICIT ANTIGEN-SPECIFIC T-CELLS
­BACTERIA-ENGINEERED TO ELICIT ANTIGEN-SPECIFIC T-CELLS Researchers at Stanford have developed a new avenue for stimulating T effector and Treg immune cells in an antigen-specific manner. Commensal microbiota have been shown to functionally regulate the innate and adaptive immune systems and must establish distinct niches at barrier sites throughout...
Published: 10/6/2023   |   Inventor(s): Michael Fischbach, Kazuki Nagashima, Yiyin Chen, Djenet Bousbaine
Keywords(s): Autoimmune, Bacteria, T-Cell Activation
Category(s): Technology Classifications > Biology
­BACTERIA-ENGINEERED TO ELICIT ANTIGEN-SPECIFIC T-CELLS
­BACTERIA-ENGINEERED TO ELICIT ANTIGEN-SPECIFIC T-CELLS Researchers at Stanford have developed a new avenue for stimulating T effector and Treg immune cells in an antigen-specific manner. Commensal microbiota have been shown to functionally regulate the innate and adaptive immune systems and must establish distinct niches at barrier sites throughout...
Published: 10/6/2023   |   Inventor(s): Michael Fischbach, Kazuki Nagashima, Yiyin Chen
Keywords(s): Autoimmune, Bacteria, T-Cell Activation
Category(s): Technology Classifications > Biology
HIGH-THROUGHPUT FORCE-DEPENDENT CELLULAR RESPONSE ASSAY USING SPECTRALLY ENCODED SMART BEADS
­HIGH-THROUGHPUT FORCE-DEPENDENT CELLULAR RESPONSE ASSAY USING SPECTRALLY ENCODED SMART BEADS Researchers at Stanford have developed a technology that uses biomechanical force to initiate T-cell triggering in a high throughput method, facilitating the exploration of the force- and sequence-dependent landscape of T-cell responses. Adaptive immunity...
Published: 3/17/2023   |   Inventor(s): Xiang Zhao, Adam White, Polly Fordyce, Yinnian Feng, K Garcia
Keywords(s): Catch Bond, High-Throughput Mechanobiology, Ligand Discrimination, Mechanotransduction, Single-Cell Microfluidics, Spectrally Encoded Beads, T-Cell Activation, T-Cell Biophysics, T-Cell Receptor
Category(s): Technology Classifications > Biology