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Search Results - epigenetics
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Inhibition of BMI1 Eliminated Cancer Stem Cells and Activates Antitumor Immunity (UCLA Case No. 2020-858)
UCLA researchers in the Department of Dentistry discovered that targeting BMI1in head and neck squamous cell carcinoma (HNSCC) may be a viable immune checkpoint to inhibit metastatic tumor growth, and prevent tumor relapse through activation of cell-intrinsic immunity and purging cancer stem cells (CSCs). BACKGROUND: Cancer stem cells are cancer...
Published: 3/6/2024
|
Inventor(s):
Cun-Yu Wang
,
Jia Lingfei
Keywords(s):
Cancer stem cells
,
Epigenetics
,
Immunooncology
,
Oncology Immunotherapy
,
Tumor
Category(s):
Therapeutics > Oncology > Oncology Immunotherapy
,
Therapeutics > Gene Therapy And Editing
A Process for Identifying Health Modifying Interventions Through Epigenetic Prediction (Case No. 2023-107)
Summary: UCLA researchers in the Department of Neurology have developed a novel method that leverages epigenetic markers to identify recommended and necessary health interventions. Background: Disease risk prediction and intervention involves identifying individuals or populations with a higher likelihood of developing a particular condition based...
Published: 3/22/2024
|
Inventor(s):
Noah Zaitlen
,
Eran Halperin
,
Elior Rahmani
,
Michael Thompson
,
Zeyuan (Johnson) Chen
Keywords(s):
Clinical decision support system
,
clinical outcome
,
Clinical Trial
,
disease outcome
,
Epigenetics
,
health risk assessment
,
outcome probability
,
patient outcome
,
prognostic
,
Public Health
,
public health monitoring
,
Risk Assessment
,
risk reduction
,
risk score
,
Simulation & Modeling
,
statistical modeling
,
treatment efficacy
Category(s):
Software & Algorithms
,
Software & Algorithms > Data Analytics
,
Software & Algorithms > Digital Health
,
Software & Algorithms > Statistical Models
,
Medical Devices
,
Medical Devices > Monitoring And Recording Systems
Targeted Epigenetic Editing as Novel Therapy for Malignant Glioma (UCLA Case No. 2023-047)
UCLA Researchers in the Department of Neurology/Neuro-Oncology and the David Geffen School of Medicine have developed methods for the Cas9-CRISPR mediated epigenetic targeting of malignant glioma, and which results in enhanced chemosensitivity to standard chemotherapeutic agents. BACKGROUND: Malignant gliomas are aggressive brain tumors originating...
Published: 1/17/2024
|
Inventor(s):
Serendipity Zapanta Rinonos
,
Albert Lai
Keywords(s):
Brain
,
Cancer
,
Cancer stem cells
,
Chemotherapy
,
Combination therapy
,
CRISPR
,
CRISPR-Cas9
,
Epigenetics
,
GBM
,
Glioma
Category(s):
Therapeutics > Oncology
,
Therapeutics > CNS and Neurology
Profiling Chemically Modified DNA/RNA Units for Disease and Cancer Diagnosis
Diagnose a wide variety of conditions by analyzing DNA and RNA nucleotides/nucleosides. Background: In theory, RNA and DNA can be used to diagnose a broad range of diseases. Unfortunately, there are no existing technologies capable of providing comprehensive profiles of variant DNA/RNA components. Established approaches for the analysis/detection of...
Published: 9/24/2024
|
Inventor(s):
Daniele Fabris
,
Rebecca Rose
Keywords(s):
cancer
,
DNA modifications
,
epigenetics
,
genome-wide analysis
,
infection
,
oncology
,
RNA modifications
,
Technologies
Category(s):
Technology Classifications > Diagnostics
,
Campus > University at Albany
METHODS FOR MEASURING PROTEIN-DNA INTERACTIONS WITH LONG READ DNA SEQUENCING
METHODS FOR MEASURING PROTEIN-DNA INTERACTIONS WITH LONG READ DNA SEQUENCING Researchers at the University of California Berkeley and Stanford have developed a bespoke, high throughput method for determining DNA-protein interactions in highly repetitive portions of the human genome. Protein-DNA interactions are essential to the reading, regulation,...
Published: 3/17/2023
|
Inventor(s):
Aaron Streets
,
Nicolas Altemose
,
Annie Maslan
Keywords(s):
ChIP-Seq
,
DNA-Protein Interaction
,
Epigenetics
,
Long-read Sequencing
Category(s):
Technology Classifications > Biology
METHOD FOR COMBINED GENOME METHYLATION AND VARIATION ANALYSES
METHOD FOR COMBINED GENOME METHYLATION AND VARIATION ANALYSES Researchers at Stanford have developed improved methods for combined analyses of
epigenetics
and nucleotide variation in single cells. Single cell genomic sequencing has allowed characterization of the diversity and evolution of cells within tissues. Recent advances in whole genome...
Published: 3/17/2023
|
Inventor(s):
Veronica Gonzalez-Pena
,
Charles Gawad
Keywords(s):
Biomolecules
,
Epigenetics
,
Methylation
,
Single Cell
,
Single Cell Analysis
,
Single Cell Genomics
Category(s):
Technology Classifications > Biology
Test Kit that Simultaneously Measures DNA Methylation and Chromatin Structure to Identify Cancer and Other Diseases
Integrates DNA Methylation and Chromatin Structure Assessment to Better Predict Chance of DiseaseThis integrated DNA test kit helps diagnose disease by measuring methylation and chromatin structure at the same time, giving it an edge over disease detection kits that employ separate evaluations. Locked inside every tissue sample is valuable information...
Published: 6/27/2021
|
Inventor(s):
Michael Kladde
,
Nancy Nabilsi
,
Carolina Pardo
Keywords(s):
Chromatin
,
DNA Methylation
,
Epigenetics
Category(s):
Technology Classifications > Research Tools > Others