Search Results - cancer

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Method for Repurposing FDA-approved Therapeutics & Composition for Treating Mesothelioma

The amount of time and money that goes into getting a drug from initial discovery to FDA approval is substantial, typically involving at least 10 years and hundreds of millions of dollars. Because of this, there has been a growing interest in repurposing drugs which have previously been approved for human use, particularly since their MOA as well as...

Published: 1/8/2025 | Inventor(s): Chris Plaisier, Sierra Wilferd, Choung Hoang

Keywords(s): Cancer, Drug, Drug Discovery

Category(s): Pharmaceuticals, Cancer, Cancer Therapeutics, Artificial Intelligence/Machine Learning, Computing & Information Technology, Life Science (All LS Techs)

RNA Sensor Platform for Targeting Cancer Fusion Genes and Transcripts

Many cancers have recurrent chromosomal translocations leading to the fusion of two genes. Often, said cancers are aggressive, have a poor prognosis with metastasis or recurrence, and do not have effective and targeted treatment. The challenge of many fusion-positive cancers is the lack of established targets downstream of the gene fusion despite years...

Published: 10/8/2024 | Inventor(s): Albert Cheng, Ching Lau, Nathaniel Jilette, Jacqueline Jufen Zhu

Keywords(s):

Category(s): Cancer, Cancer Therapeutics, Chemical/Biological Sensors, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)

Microfluidic Digital Nanobiosensors for Point-of-Care Detection of Analytes

Detection, identification and quantification of molecular biomarkers, such as proteins, peptides, exosomes, hormones, neurotransmitters, metabolites and nucleic acids, are critical to disease diagnosis, progression monitoring, and management. While there are numerous approaches for analyzing biomarkers, the most validated and well-established is ELISA....

Published: 8/27/2024 | Inventor(s):

Keywords(s):

Category(s): Bioanalytical Assays, Chemistries & Devices, Cancer, Imaging, Life Science (All LS Techs), Medical Devices, Medical Diagnostics/Sensors

Anti-Galectin-1 Monoclonal Antibody

Galectin-1 (Gal-1) is a ubiquitously expressed galactoside-binding 14-kDa lectin that is differentially expressed by a variety of pathological as well as normal cell types. Extracellular Gal-1 has been shown to exert strong Immunomodulatory activity and has been implicated in numerous cancer and autoimmune diseases. Further, recent research has shown...

Published: 7/2/2024 | Inventor(s): Douglas Lake, Kirsten Pfeffer, Thai Ho

Keywords(s):

Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Cancer, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors

Tandem Antigen Capture ELISAs for Measuring Short and Long Isoforms of QSOX1

Quiescin sulfhydryl oxidase1 (QSOX1) is a sulfhydryl oxidase that is overexpressed in several malignancies and as such is a potential biomarker for multiple cancer types as well as acute decompensated heart failure (ADHF). Since its discovery, QSOX1 has been identified as a key player in the facilitation of tumor cell migration, creating a significant...

Published: 5/31/2024 | Inventor(s): Douglas Lake, Thai Ho, Calvin Koelbel

Keywords(s):

Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Cancer, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Life Science (All LS Techs)

Optical Imaging Platform for POC CAR T-Cell Therapy Assessment

Chimeric antigen receptor (CAR) T-cell therapy is a type of immunotherapy which uses altered T-cells to target cancer cells more effectively. As such, it has dramatically changed the treatment landscape for cancer patients. However, it has limitations including cytokine release syndrome (CRS), neurological events (NE), lack of response (which occurs...

Published: 8/27/2024 | Inventor(s): Shaopeng Wang, Nanxi Yu, Chao Chen, Xinyu Zhou, Januario Castro, Eider Moreno Cortes

Keywords(s):

Category(s): Medical Diagnostics/Sensors, Medical Devices, Life Science (All LS Techs), Imaging, Cancer, Bioanalytical Assays, Chemistries & Devices

HLA-Inception: MHC-Peptide Binding Prediction

Major histocompatibility complex class I (MHC-I) molecules are principal components of immune recognition. Peptide binding to MHC-I molecules is necessary for antigen presentation and T cell recognition. Understanding and predicting MHC-I binding has great utility in T cell therapies, vaccine development and treatment of complex human diseases. Unfortunately,...

Published: 10/10/2024 | Inventor(s): Eric Wilson, Abhishek Singharoy, Karen Anderson, John Cava

Keywords(s):

Category(s): Applied Technologies, Computing & Information Technology, Cancer, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools

Label-Free Detection Platform for CircRNAs

Circular RNAs (circRNAs) hold great potential as novel biological and clinical biomarkers for diagnosis and prognosis of cancer and other diseases. Conventional detection techniques such as northern blotting, microarray, qRT-PCR and RNA-seq suffer from many issues including low sensitivity and background noise, which limit the use of circRNA in clinical...

Published: 1/19/2024 | Inventor(s): Hao Yan, Yang Xu, Shaopeng Wang, Zijian Wan, Liangxiao Chen

Keywords(s):

Category(s): Life Science (All LS Techs), Medical Diagnostics/Sensors, Imaging, Advanced Materials/Nanotechnology, Biomaterials, Bioanalytical Assays, Chemistries & Devices, Cancer

Targeted Therapy for Triple-Negative Breast Cancer

Breast cancer is the second leading cause of death in women and is the most common cancer among women worldwide. There are four main breast cancer subtypes, luminal A, luminal B, HER2-positive and triple-negative. Triple-negative breast cancer (TNBC) is highly invasive and has higher rates of metastasis and a worse prognosis. Metastasis of cancer cells...

Published: 9/12/2023 | Inventor(s): Shengxi Chen, Xiaojiang Cui, Yi Zhang, Sidney Hecht

Keywords(s):

Category(s): Life Science (All LS Techs), Advanced Materials/Nanotechnology, Cancer, Cancer Therapeutics, Pharmaceuticals

Antimicrobial Antibody Panels for Lung Cancer Detection

the second most common cancer in both men and women and the leading cause of cancer death in the US. Although there are risk factors for lung cancer, such as smoking, there are many cases where the patient never smoked. Because of this, there is growing interest in investigating the lung microbiota and how that may promote or prevent disease. Yearly...

Published: 8/2/2023 | Inventor(s): Mahasish Shome, Ji Qiu, Yunro Chung, Joshua LaBaer

Keywords(s):

Category(s): Cancer, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools

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