Search Results - cancer

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Enhanced Combinatorial Oncolytic Virotherapy

Oncolytic viruses (OVs) are able to selectively infect and kill cancer cells without damaging normal cells. They can be used as a monotherapy, or they can be combined with existing cancer therapeutics for increased potency. While much progress has been made around OVs, one of their biggest limitations is their inability to successfully replicate, spread,...

Published: 3/31/2025 | Inventor(s): Mohammed Masmudur Rahman

Keywords(s):

Category(s): Cancer, Cancer Therapeutics, Life Science (All LS Techs), Pharmaceuticals

Affinity Encoded Nano-Oscillator Array

Nanoarray-based assays offer advantages over standard microarray assays such as minimal sample consumption, high efficiency, and enhanced multiplexing capacity. However, despite their potential, they face challenges such as the complexity and high cost of spotting and fabrication, as well as a lack of effective detection schemes. This impedes many practical...

Published: 3/4/2025 | Inventor(s): Shaopeng Wang, Shuo-Hui Cao

Keywords(s):

Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Cancer, Life Science (All LS Techs), Imaging, Proteomic Assays/Reagents/Tools, Chemical/Biological Sensors

Neutrophil based CAR Therapies for Treatment

Chimeric antigen receptor (CAR)-T-cell-based immunotherapies have dramatically improved survival in cancer patients. Unfortunately, CAR-T cell therapies are associated with severe neurotoxicity, adverse events during clinical trials, and cytokine storm syndrome among others. Therefore, there is a great need to develop strategies that can keep the benefits...

Published: 2/19/2025 | Inventor(s): Abhinav Acharya, Mamta Wankhede

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Cancer, Cancer Therapeutics, Life Science (All LS Techs), Pharmaceuticals, Nucleic Acid/Peptide/Protein Therapies

Metabolite Delivery for Modulating Metabolic Pathways of Cells

There is a great need to deliver metabolites intracellularly without modifying the metabolite itself and rescue immune cells against metabolic exhaustion. In cancer therapy, metabolic pathway inhibitors are used that starve both cancerous cells as well as non-cancerous cells. Therefore, the ability to target specific immune cells and deliver metabolites...

Published: 2/19/2025 | Inventor(s): Abhinav Acharya

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Cancer Therapeutics, Cancer, Life Science (All LS Techs), Pharmaceuticals, Nucleic Acid/Peptide/Protein Therapies

Central Carbon Metabolite Based Polymers for Immunotherapy

Inhibition of glycolysis or glutaminase pathway is an effective strategy to prevent cancer cell growth in vitro and in vivo. However, these pathways are also utilized by immune cells to mount responses against cancer cells, and therefore, utilizing, immunotherapies in the presence of such inhibitors is challenging. Thus, there is a need for technologies...

Published: 2/19/2025 | Inventor(s): Abhinav Acharya, Sahil H Inamdar

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Cancer, Cancer Therapeutics, Life Science (All LS Techs), Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals

Central Carbon Metabolite Based Polymers for Tissue Regeneration

There is a rich history of successful drug delivery carriers made of biodegradable biomaterials. Biomaterials may degrade into metabolic by-products, which are capable of modulating the function of immune cells, including alpha-ketoglutarate (aKG), which induces alternative activation (immunosuppressive phenotype) in macrophages through metabolic reprogramming....

Published: 2/19/2025 | Inventor(s): Abhinav Acharya, Kaushal Rege

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Non-Cancer Therapeutics, Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals, Cancer

Rescue from Glycolysis and mRNA Based Vaccines

Glycolysis inhibition in cancer cells has long been recognized as a viable strategy to prevent cancer cell growth. Cancer cells are known to have a high glucose consumption rate as a metabolism adaptation mechanism called the Warburg effect. Activated immune cells also rely on glycolysis for their energy needs. For example, glycolysis is essential for...

Published: 2/19/2025 | Inventor(s): Abhinav Acharya

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Life Science (All LS Techs), Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals, Vaccines/Antimicrobials, Cancer, Cancer Therapeutics, Biomaterials

Metabolically-fit Immunotherapies Portfolio

M23-139L – Inducing or Rescuing Glycolysis in Cancer Cells. Compositions that selectively block glycolysis in cancer cells while simultaneously enable glycolysis in non-cancer cells, such as macrophages, T cells, NK cells, etc. Vaccine formulations have been developed and tested on mice with positive results. Please see the published PCT (WO2024151709A1)...

Published: 2/13/2025 | Inventor(s):

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Biological Nanotechnology, Cancer, Cancer Therapeutics, Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals, Vaccines/Antimicrobials

Methods for Enhancing Production of Beneficial Short- and Medium- Chain Fatty Acids by the Gut Microbiome

Short-chain fatty acids (SCFAs) which include acetate (C2), propionate (C3) and butyrate (C4) are important, health-benefiting metabolites, produced when microbes in the human colon ferment polysaccharides and dietary fiber. Medium-chain fatty acids (MCFAs), such as caproate (C6) and caprylate (C8), have also been shown to provide health benefits and...

Published: 2/13/2025 | Inventor(s): Anca Delgado, Rosa Krajmalnik-Brown, Dorsa Daeizadeh

Keywords(s):

Category(s): Life Science (All LS Techs), Microbiome, Neurodegenerative Disease Technologies, Cancer, Cancer Therapeutics

Method for Repurposing FDA-approved Therapeutics & Composition for Treating Mesothelioma

The amount of time and money that goes into getting a drug from initial discovery to FDA approval is substantial, typically involving at least 10 years and hundreds of millions of dollars. Because of this, there has been a growing interest in repurposing drugs which have previously been approved for human use, particularly since their MOA as well as...

Published: 2/18/2025 | Inventor(s): Chris Plaisier, Sierra Wilferd, Choung Hoang

Keywords(s): Cancer, Drug, Drug Discovery

Category(s): Pharmaceuticals, Cancer, Cancer Therapeutics, Artificial Intelligence/Machine Learning, Computing & Information Technology, Life Science (All LS Techs)

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