Search Results - cardiological+diseases+treatment

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A Novel Immunomodulatory Strategy for Treating Heart Failure in Aging Populations
Advantages Novel Mechanism of Action: Targets the Th17/IL17A signaling axis Validated Target: IL17A is already clinically validated in other inflammatory diseases (e.g., psoriasis, psoriatic arthritis), with FDA-approved therapies like secukinumab Strong Preclinical POC: transcriptomic, histological, and functional cardiac assessments showing reversal...
Published: 6/22/2026   |   Updated: 8/25/2025   |   Inventor(s): Wanling Xuan, Srinivas Tipparaju
Keywords(s): Cardiological Diseases Treatment, Cardiovascular Diseases, Drug Discovery
Category(s): zzCardiology, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
Targeting Nox4 to Treat Dystrophic Cardiomyopathy
Advantages: • First‑in‑class therapy directly targeting the dystrophic cardiac pathway • Robust in vivo efficacy across multiple DMD mouse models • Clinically tractable drug class with multiple candidate molecules provides rapid development pathways, repurposing potential: setanaxib (GKT137831), VAS2870, and GSK2795039 •...
Published: 6/22/2026   |   Updated: 4/1/2025   |   Inventor(s): Da-Zhi Wang, Zhanpeng Huang, Jianming Liu
Keywords(s): Cardiological Diseases Treatment
Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Therapeutics
Novel MRPS5 Mitochondrial Target for Heart Failure Regeneration
Advantages: Novel Mitochondrial Target Driving Cardiomyocyte Proliferation Enables regeneration of functional heart muscle, going beyond symptomatic treatment Induces cardiomyocyte proliferation while preserving overall mitochondrial function In Vivo Proof-of-Concept Showing Improved Cardiac Function and Reduced Infarct Size Amenable...
Published: 6/22/2026   |   Updated: 11/22/2024   |   Inventor(s): Da-Zhi Wang, John Mably
Keywords(s): Biotechnology, Cardiological Diseases Treatment, Cell & Tissue Culture & Engineering, Medical Diagnostics, Pharmaceuticals
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Pharmaceuticals
Kcnab2 Conditional Knockout Mouse Model
­Advantages: A new Kcnab2 exon 4-floxed mice, suitable for experimental models to study muscle development, regeneration, and pathogenesis Kcnab2 exon 4-floxed mice were successfully generated using CRISPR/Case9 technology Allows for specific study of the Kcanb2 function on skeletal muscle (e.g. TA) without significant changes in the brain...
Published: 6/22/2026   |   Updated: 8/6/2024   |   Inventor(s): Srinivas Tipparaju
Keywords(s): Animal Models, Cardiological Diseases Treatment, Cardiovascular Diseases
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Cell & Tissue Engineering
A Constitutive-based Machine Learning Model for The Identification of Active Contraction Properties in the Ventricular Myocardium
­Advantages: The deep learning-based approach enables accurate forecasting of left ventricular active contractions, providing early indicators of potential cardiovascular diseases, allowing for timely intervention and improved patient outcomes. The technology utilizes clinical metrics and imaging data, avoiding invasive procedures, and reducing...
Published: 6/22/2026   |   Updated: 8/15/2023   |   Inventor(s): Igor Nobrega
Keywords(s): Cardiological Diseases Treatment, Cardiovascular Diseases, Machine Learning
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Medical Imaging