Search Results - cell+%26+tissue+culture+%26+engineering

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Novel Cell Lines and Mouse Model to Study Congenital Heart Defects
Advantages: Mutant mouse lines with various CDK13 mutations Identified cardiac specific CDK13 mutations which mirror heart defect development Genetically modified human induced pluripotent stem cells can be differentiated into different cardiac cell types Provides method for screening potential therapeutic agents for congenital heart defects Summary: Congenital...
Published: 5/9/2025   |   Inventor(s): Joanne Chan, DaZhi Wang
Keywords(s): Animal Models, Cardiovascular Diseases, Cell & Tissue Culture & Engineering
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering
New Target for Heart Failure Therapies: Modifying MRPS5/ATF4 Signaling in Cardiomyocytes
Advantages: Identification of MRPS5 as a Therapeutic Target: Reduction of MRPS5 expression stimulates cardiomyocyte proliferation and enhances heart function Discovery of the MRPS5 signaling axis: Decreased MRPS5 enhances ATF4 and Knl1, which promote cardiomyocyte, boosting cardiac recovery after myocardial injury Improved Survival and Cardiac...
Published: 1/17/2025   |   Inventor(s): Da-Zhi Wang, John Mably
Keywords(s): Biotechnology, Cardiological Diseases Treatment, Cell & Tissue Culture & Engineering, Medical Diagnostics, Pharmaceuticals
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Pharmaceuticals
Protein Palmiotylation Inhibitors of SARS Viruses
­Competitive Advantages Novel treatment for Covid-19 Inhibits palmitoylation of SARS-CoV-2 spike proteins resulting in reduced virus infectivity Inhibits syncytia formation Summary The last two decades have seen the emergence of three major corona virus(CoV) outbreaks. The SARS-CoV-2 spike glycoprotein (S) is a 1273 amino acids type I membrane...
Published: 8/8/2024   |   Inventor(s): Robert Deschenes, Arunava Roy, Ahmed Ramadan, Subhra Mohapatra, Marcello Giulianotti
Keywords(s): Cell & Tissue Culture & Engineering, Covid-19, Respiratory Diseases, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Respiratory