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Pyridinium-Based Cyclophanes as Synthetic Lectins and Their Use for Glucose Recognition and Sensing in Aqueous Solutions

Advantages: Highly sensitive glucose sensor with strong potential for use in biomedical diagnostics and continuous glucose monitoring. Flexible, adaptive binding pocket that selectively targets glucose’s functional groups, improving specificity and detection accuracy. Reversible, non-covalent binding to glucose, allowing real-time response...

Published: 11/8/2024 | Inventor(s): Wenqi Liu

Keywords(s): Biotechnology, Diabetes, Pharmaceuticals

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical

Heavy Metal Sensing

VALUE PROPOSITION Heavy metal pollution in soils is widespread in the world, resulting from both natural sources and human activities (e.g., mining and smelting, industrial emission, fossil fuel combustion, etc.). Due to their toxicity, bioaccumulation, and environmental persistence, elevated levels of heavy metals in the environment pose major threats...

Published: 9/13/2024 | Inventor(s): Wen Li, Hasan Banna, James Siegenthaler

Keywords(s):

Category(s): Agriculture, Analytical Instruments, Environment, Test and Measurement

DNA Methylation Barriers

In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...

Published: 6/5/2024 | Inventor(s): Li Liu, Jingmin Shu

Keywords(s):

Category(s): Applied Technologies, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Diagnostic Assays/Devices

Recovering Critical Elements from Acid Mine Drainage

THE CHALLENGE The demand for certain elements, such as Manganese (Mn), Cobalt (Co), and Nickel (Ni), has surged in recent years due to the rapid growth of battery production for electric vehicles and utility-scale energy storage. The United States government has deemed Co, Ni, and Mn critical elements, primarily because of the country’s high...

Published: 6/26/2024 | Inventor(s): Wencai Zhang, Qi Li, Rick Honaker

Keywords(s):

Category(s): Technology Classifications > Energy, Technology Classifications > Mining and Recycling, Technology Classifications, Technology Classifications > Chemicals/Materials

Scribble: Optimised Segmentation of Medical Images through AI

Summary: A semi-automated, artificial-intelligence based, interactive method for selecting a structure in a medical image, that requires only limited input from the users. What Segmentation is used extensively in medical imaging to highlight specific structures (e.g. an organ, a blood vessel or a tumour) and locations that should be...

Published: 11/12/2024 | Inventor(s): Sebastien Ourselin, Tom Vercauteren, Guotai Wang, Wenqi Li, Lucas Fidon

Keywords(s):

Category(s): Software, Diagnostics, Artificial Intelligence

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...

Published: 7/30/2024 | Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li

Keywords(s):

Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment

JobViz: User Interface for Visualization of Majors & Jobs

Invention Summary: University (and industry) career search portals and web-based job search engines allow users to search on many items (e.g., education, location, level, etc.) and then present a text based list of potential job opportunities. University career portals are not as conductive to exploration by job and career searchers as they could...

Published: 9/8/2022 | Inventor(s): Deborah Silver, Li Liu

Keywords(s):

Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms

Implantable Neural Microelectrodes and Fabrication Method

Executive SummaryMicroelectrodes have become vital in the current-day attempt to map and understand the human brain, as well as delivering unique therapeutic solutions. These microelectrodes are able to work as biosensors, picking up changes in potential and electrophysiology. In particular, extracellular sensors can record data on neurotransmitter...

Published: 2/17/2023 | Inventor(s): Wen Li, Yue Guo, Thomas Schuelke, Michael Becker, Robert Rechenberg, Cory Rusinek

Keywords(s):

Category(s): Advanced Materials, Biotechnology, Devices

Flexible Hybrid Diamond Biosensor

Executive SummaryA unique fabrication method creates a new flexible and implantable thin film sensor for the biochemical, medical and neural engineering fields. This diamond-polymer hybrid demonstrates improved biocompatibility, durability and chemical sensing capabilities. Description of TechnologyThe rigidness and attachment incompatibilities of...

Published: 6/8/2021 | Inventor(s): Wen Li, Bin Fan, Michael Becker, Robert Rechenberg

Keywords(s):

Category(s): Advanced Materials, Devices

Wireless Intraocular Pressure Sensor to Monitor Glaucoma Patients

Executive SummaryGlaucoma is a leading cause of blindness that affects up to 3 million people in American. It can remain undetected until permanent vision loss is present. Measuring eye pressure during an office visit is a standard diagnostic tool. However, this measurement can only report on pressure during a brief time sample. Patients with variable...

Published: 6/15/2023 | Inventor(s): Wen Li, Arthur Weber, Mohammad Hossein Kouhani

Keywords(s):

Category(s): Medical, Biotechnology, Test and Measurement

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