Search Results - yung+chang

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Thermal Control During Additive Manufacturing

THE CHALLENGE Additive manufacturing (AM) has emerged as a powerful tool within engineering. Many AM and coating processes rely on thermal input to soften or melt the materials involved in processing. However, this melting or softening typically results in a higher thermal gradient between deposited material and the workpiece, commonly resulting in...

Published: 12/20/2023 | Inventor(s): Robert Griffiths, David Garcia, Hang Yu

Keywords(s):

Category(s): EXPERIMENT--DO NOT USE, Technology Classifications > Additive Manufacturing

Tumor-Targeted Killing with Aptamer-Nucleic Acid Nanostructures

Despite decades of research, cancer remains one of today’s most pressing health concerns. Traditional treatment approaches such as radiation therapy and chemotherapy can cause systemic toxicity and become ineffective when resistant tumors emerge. Recently, anticancer strategies have focused on drugs which specifically target tumor-related biological...

Published: 4/14/2023 | Inventor(s): Yung Chang, Hao Yan

Keywords(s): Bio-Technology, Drug Screening, Therapeutics

Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools

Creation of Multivalent Aptamers to Target Effector T Cells to Attack Tumor Cells

Despite decades of research effort, cancer remains one of today’s most pressing health concerns. Present day treatment methods tend to include debilitating side effects mainly due to low specificity of the treatments. Recently, some attempts have been made to augment tumor immunity by using bi-specific, hybrid antibodies that direct immune cells...

Published: 4/14/2023 | Inventor(s): Yung Chang, Hao Yan

Keywords(s):

Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools, Pharmaceuticals

Strategy to Design Nicotine Vaccines

Cigarette smoking causes a variety of diseases with high morbidities and mortality; however, the addictive properties of nicotine make quitting difficult. Nicotine molecules enter the brain within seconds after use and activate reward pathways, leading to dependence. Despite extensive efforts toward cessation interventions, smoking remains a major public...

Published: 2/23/2023 | Inventor(s): Yung Chang, Sidney Hecht, Joseph Leal, Viswanath Arutla, Xiaowei Liu, Sriram Sokalingam

Keywords(s): Addiction, Hapten, Immunogenecity, Linkers, Nicotine

Category(s): Life Science (All LS Techs), Advanced Materials/Nanotechnology, Pharmaceuticals, Non-Cancer Therapeutics, Vaccines/Antimicrobials

Chance-Constrained Optimization for Treatment of Prostate and Other Cancers in Intensity-Modulated Proton Therapy

The quality of IMPT treatment plans may be drastically diminished by uncertainties such as proton range and patient setup errors. If these uncertainties are not figured into treatment planning, the dose distribution that the patient receives may not be the same as the planned dose distribution. New treatment plans, which include optimized software/programming,...

Published: 4/19/2023 | Inventor(s): Jianming Liang, Yu An, Wei Liu

Keywords(s):

Category(s): Computing & Information Technology, Life Science (All LS Techs), Medical Imaging