Search Results - yung+chang

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Miniaturized Solid-State Metal Additive Manufacturing Tooling and Design
THE CHALLENGE The main challenge with current friction-based, solid-state metal additive manufacturing methods—like traditional Additive Friction Stir Deposition (AFSD)—lies in their reliance on bulky equipment, large feedstock rods, and high-force machinery, which limits flexibility, increases costs, and restricts use to factory settings....
Published: 7/3/2025   |   Inventor(s): Ryan Gottwald, Hang Yu
Keywords(s):  
Category(s): Technology Classifications > Chemicals/Materials
Modified Aluminum Alloys for High-Strain Applications
THE CHALLENGE The key challenge in advancing high-strength aluminum alloys like the 7xxx and 6xxx series lies in bridging the gap between their exceptional mechanical potential and the limitations of current manufacturing methods. While industries such as aerospace and automotive demand lightweight materials with high strength and durability, existing...
Published: 7/3/2025   |   Inventor(s): Jake Yoder, Greg Hahn, Hang Yu
Keywords(s):  
Category(s): Technology Classifications > Chemicals/Materials
Thermal Control During Additive Manufacturing
THE CHALLENGE Additive manufacturing (AM) has emerged as a powerful tool within engineering. Many AM and coating processes rely on thermal input to soften or melt the materials involved in processing. However, this melting or softening typically results in a higher thermal gradient between deposited material and the workpiece, commonly resulting in...
Published: 6/26/2025   |   Inventor(s): Robert Griffiths, David Garcia, Hang Yu
Keywords(s):  
Category(s): EXPERIMENT--DO NOT USE, Technology Classifications > Additive Manufacturing
Tumor-Targeted Killing with Aptamer-Nucleic Acid Nanostructures
Despite decades of research, cancer remains one of today’s most pressing health concerns. Traditional treatment approaches such as radiation therapy and chemotherapy can cause systemic toxicity and become ineffective when resistant tumors emerge. Recently, anticancer strategies have focused on drugs which specifically target tumor-related biological...
Published: 6/29/2025   |   Inventor(s): Yung Chang, Hao Yan
Keywords(s): Bio-Technology, Drug Screening, Therapeutics
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools
Creation of Multivalent Aptamers to Target Effector T Cells to Attack Tumor Cells
Despite decades of research effort, cancer remains one of today’s most pressing health concerns. Present day treatment methods tend to include debilitating side effects mainly due to low specificity of the treatments. Recently, some attempts have been made to augment tumor immunity by using bi-specific, hybrid antibodies that direct immune cells...
Published: 7/30/2025   |   Inventor(s): Yung Chang, Hao Yan
Keywords(s):  
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools, Pharmaceuticals
Strategy to Design Nicotine Vaccines
Cigarette smoking causes a variety of diseases with high morbidities and mortality; however, the addictive properties of nicotine make quitting difficult. Nicotine molecules enter the brain within seconds after use and activate reward pathways, leading to dependence. Despite extensive efforts toward cessation interventions, smoking remains a major public...
Published: 2/13/2025   |   Inventor(s): Yung Chang, Sidney Hecht, Joseph Leal, Viswanath Arutla, Xiaowei Liu, Sriram Sokalingam
Keywords(s): Addiction, Hapten, Immunogenecity, Linkers, Nicotine
Category(s): Life Science (All LS Techs), Advanced Materials/Nanotechnology, Pharmaceuticals, Non-Cancer Therapeutics, Vaccines/Antimicrobials
Chance-Constrained Optimization for Treatment of Prostate and Other Cancers in Intensity-Modulated Proton Therapy
The quality of IMPT treatment plans may be drastically diminished by uncertainties such as proton range and patient setup errors. If these uncertainties are not figured into treatment planning, the dose distribution that the patient receives may not be the same as the planned dose distribution. New treatment plans, which include optimized software/programming,...
Published: 7/4/2025   |   Inventor(s): Jianming Liang, Yu An, Wei Liu
Keywords(s):  
Category(s): Computing & Information Technology, Life Science (All LS Techs), Medical Imaging