Search Results - jin+he

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Agonistic antibodies against SLAMF7 for improved immunotherapy against human cancer
Novel Multiple Myeloma Therapy trough SIRP-alpha and SLAMF7 blockade New and first-in-class anti-SLAMF7 monoclonal antibody (Z10) Credit Shutterstock : 1878567847 UNMET NEED Multiple myeloma is a hematological cancer characterized by a clonal expansion of plasma cells. There are approximatively 2500 new cases per year in Canada and 35000...
Published: 7/25/2025   |   Inventor(s): Ming-Chao Zhong, Jin Qian, Zhenghai Tang, André Veillette
Keywords(s): Innovation
Category(s): Applications > Soins et santé > Traitement > Pharmaceutique > Oncologie, English Applications > Health and care > Treatment > Pharmaceuticals > Oncology, Secteurs > Sciences de la vie, Sectors > Life sciences, Objectifs de Développement Durable > ODD 03 : Bonne santé et bien-être, Sustainable Development Goals > Goal 03: Good Health and Well-Being
Dynamic-based Computational Drug Design Strategy for WW Domains
Understanding the relationship between protein sequence-structure and binding dynamics is not well understood. Of particular interest is the ability to relate foldability and function of a protein and the ability to characterize how foldability and binding change based on mutations in the protein sequence. WW domains are one of the most abundant independently...
Published: 6/3/2025   |   Inventor(s): Jin Lu, Ismail Can Kazan, Sefika Banu Ozkan
Keywords(s):  
Category(s): Artificial Intelligence/Machine Learning, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 5/30/2025   |   Inventor(s): Yong Zeng, He Yan
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics
Controlled Tunnel Gap Device for Sequencing Polymers
To reduce costs and increase the availability of personalized genomics new approaches to DNA sequencing are required. Nanopore sequencing is one proposed technique. In nanopore sequencing, DNA molecules are forced through a tiny aperture by electrophoresis. As the individual bases transit the nanopore, their identity can be determined, in theory, by...
Published: 2/13/2025   |   Inventor(s): Stuart Lindsay, Shuai Chang, Jin He, Peiming Zhang, Shuo Huang
Keywords(s): Bio-Technology
Category(s): Life Science (All LS Techs)
DNA Sequencing by Molecular Recognition and Nanoscale Manipulation of Single Molecules
The US Government’s pursuit of the “Thousand Dollar Genome” and the “X Prize” goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will...
Published: 2/13/2025   |   Inventor(s): Stuart Lindsay, Colin Nuckolls, Jinyao Tang, Jin He, Peiming Zhang, Kevin Reinhart
Keywords(s):  
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Proteomic Assays/Reagents/Tools
DNA Sequencing by Molecular Recognition and Nanoscale Manipulation of Single Molecules
The US Government's pursuit of the "Thousand Dollar Genome" and the "X Prize" goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will open a new...
Published: 2/13/2025   |   Inventor(s): Stuart Lindsay, Jin He, Peiming Zhang, Kevin Reinhart
Keywords(s):  
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools
Interleukin-27 Producing B-Cell Population and Uses Thereof
Summary: The National Eye Institute (NEI) seeks research co-development partners and/or licensees to advance the production and uses of interleukin-27 (IL-27) producing B-regulatory cell (i27-Breg) therapy for immune related autoimmune disorders. These disorders include but are not limited, to age-related macular degeneration (AMD), graft-versus-host...
Published: 6/10/2025   |   Inventor(s): Charles Egwuagu, Jin Choi
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Neurology, TherapeuticArea > Immunology, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Licensing
Improved resuscitation in hemorrhagic shock using polyethelyne glycol modified albumin (PEG-Alb).
Background Capillary leakage of important ions and proteins, such as albumin from blood vessels can lead to a buildup of fluid in interstitial space (organ swelling) as well as hypoperfusion of organs. Capillary leak (CL) is a central component of multiorgan failure and a secondary component to severe sepsis caused by bacterial or viral infections,...
Published: 5/9/2024   |   Inventor(s): Ragheb Assaly, J Dignam, Joseph Shapiro
Keywords(s):  
Category(s): Inflammation & Immunity
Antimicrobial Antibody Panels for Lung Cancer Detection
the second most common cancer in both men and women and the leading cause of cancer death in the US. Although there are risk factors for lung cancer, such as smoking, there are many cases where the patient never smoked. Because of this, there is growing interest in investigating the lung microbiota and how that may promote or prevent disease. Yearly...
Published: 2/13/2025   |   Inventor(s): Mahasish Shome, Ji Qiu, Yunro Chung, Joshua LaBaer
Keywords(s):  
Category(s): Cancer, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools
Treatment of caries using probiotics
Background Dental caries, also known as tooth decay or cavity is one of the world's most common oral health problems today. According to the World Health Organization (WHO), 60%-90% of school-aged children and nearly 100% of adults worldwide have dental cavities. They can affect people in a variety of ways, including infections, tooth pain, stunting...
Published: 7/1/2025   |   Inventor(s): Jin Xiao
Keywords(s):  
Category(s): Therapeutic
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