Search Results - cytokines

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3D Scaffold for T Cell Delivery and Suppression of Tregs for Solid Tumors (UCLA Case No. 2020-193)
SUMMARY: UCLA researchers in the Department of Bioengineering have developed a small and biodegradable implant that when placed adjacent to solid tumors, enhances immune response to cancer cells. BACKGROUND: The body’s immune system uses proteins called antibodies to train the immune response to foreign pathogens. This mechanism can combat...
Published: 12/3/2024   |   Inventor(s): Manish Butte
Keywords(s): cytokines, Drug Delivery, Immunotherapy, Nanoparticles, scaffolds, solid tumors, T-cell activation, t-cells
Category(s): Platforms > Drug Delivery > Nanoparticles
Biomaterial-Based Vaccine Booster to Enhance Long-Term Immunity (UCLA Case No. 2021-170)
UCLA researchers have developed injectable, cell-free, and biomaterial-based microparticles that can engage with tissue resident immune cells and enhance long-term immunity. It is the first biomaterial-based, targeted approach to induce T memory stem cells (TMSCs) in vivo. The approach was demonstrated for SARS-CoV-2 but can be used for any vaccine....
Published: 2/26/2024   |   Inventor(s): Mohammad Hasani-Sadrabadi, Song Li, Manish Butte
Keywords(s): aAPCs, Aging, artificial presenting cells, cytokines, elderly, immunosenescence, microparticles, platform technology, SARS-CoV-2, T memory stem cells, TMSCs, Vaccines
Category(s): Therapeutics > Infectious Diseases, Therapeutics > Oncology
Blood-cytokine levels as adverse outcome predictors following biomaterial implant surgery
Reference #: 01566 The University of South Carolina is offering licensing opportunities for Blood-cytokine levels as adverse outcome predictors following biomaterial implant surgery Background: Despite the high number of patients undergoing reconstruction surgery with surgical mesh and the relatively high number of adverse outcomes, there are currently...
Published: 9/26/2023   |   Inventor(s): Melissa Moss, Mihyun Waugh, Nicholas Boltin, Lauren Wolf, Ronnie Horner, Matthew Hermes, Thomas Wheeler, Richard Goodwin
Keywords(s): anti-inflammatory biotech, anti-inflammatory pharma, biomaterial implant, Blood samples, cytokines, implant rejection, inflammation, pelvic organ prolapse, plasma, predictive outcome, principal component analysis, surgical mesh
Category(s): Health Sciences