Search Results - immunocompromised

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In vitro Generation of an Autologous Thymic Organoid from Human Pluripotent Stem Cells
Abstract: The thymus is an integral part of the adaptive immune system as it generates T cells. Its function diminishes rapidly as the body ages, leading to a compromise of the immune system in the elderly. Reconstitution of adaptive immunity through mass production of different T cell types is therefore a therapeutic need in immunocompromised populations....
Published: 4/8/2024   |   Inventor(s): Raul Sakoda, Nicholas Restifo
Keywords(s): Aging, IMMUNOCOMPROMISED, Immunotherapy, Natural Killer T Cells, NKT, Organogenesis, Organoid, Pluripotent Stem Cells, T Cells, THYMUS, Vizcardo
Category(s): Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Collaboration Sought > Licensing
Nucleic Acid-based Compositions and Methods for the Detection of Pathogenic Candida or Aspergillus Fungi Species
This invention pertains to the development of oligonucleotides for the rapid nucleic acid-based identification of Candida or Aspergillus fungi species in biological samples. This identification is accomplished by the targeting the internally transcribed spacer-2 (ITS2) region that are unique to various Candida species. The assay is sensitive, specific...
Published: 10/28/2024   |   Inventor(s): Errol Reiss, Brian Holloway, Jong Shin, Christine Morrison
Keywords(s): AIDS, Aspergilli, Aspergillus, assay, CANDIDA, CANDIDA ALBICANS, candidiasis, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA1XXX, DAXXXX, Detection, diagnostic, DXXXXX, FUNGAL, FUNGI, FUNGI COMPONENTS, fungus, HIV, Immuno-comprimised, IMMUNOCOMPROMISED, Methods, Spp, thrush, VKXXXX, VOXXXX, VPXXXX, WBXXXX, WCXXXX, WIXXXX, XCXXXX, XEXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, Application > Occupational Safety and Health, Application > Therapeutics, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, Application > Consumer Products, TherapeuticArea > Oncology, TherapeuticArea > Endocrinology
Methods for Prevention and Treatment of Polyomavirus Infection or Reactivation (E-179-2007)
Available for licensing and commercial development are methods of using Tranilast [N-(3',4'-dimethoxycinnamoyl)anthranilic acid] in the prevention and treatment of human polyomavirus infection. Treatment with Tranilast decreases viral protein expression for two human polyomavirus species, JC virus (JCV) and BK virus (BKV). Furthermore, the increase...
Published: 4/8/2024   |   Inventor(s): Jeffrey Kopp, Eugene Major, Veerasamy Ravichandran
Keywords(s): BBXXXX, BK, BKV, DB4XXX, DBXXXX, DXXXXX, HIV AIDS, IMMUNOCOMPROMISED, Infection, inhibitor, JC, JCV, leukoencephalopathy, lymphoma, nephrophathy, PML, polyomavirus, Polyomavirus Infections, Polyomaviruses, Progressive multifocal leukoencephalopathy, TGF-B, Tranilast, virus
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics
A Target and Screening System for the Identification of therapeutic candidates against secondary viral infections in cancer and immunocompromised diseaes
A target and screening system for the identification of therapeutic candidates against secondary viral infections in cancer and immunocompromised diseases Docket # 12-2771 Researchers in the molecular biology department at Princeton University, together with researchers in the department of microbiology and immunology, School of Medicine, University...
Published: 3/30/2022   |   Inventor(s): Danna Hargett, Stephen St. Jeor, Lisa Keyes, Mariana Bego
Keywords(s): anti-viral, cancer/oncology, drug target, human cytomegalovirus, immunocompromised
Category(s): Biotechnology/Pharmaceuticals