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Zirconium-89 PET Imaging Agent for Cancer

Abstract: Researchers at the NCI Radiation Oncology Branch and NIH CIT Center for Molecular Modeling developed a tetrahydroxamate chelation technology that provides a more-stable Zr-89 complex as an immuno-PET cancer imaging agent. In either the linear or the macrocyclic form, the tetrahydroxamate complexes exhibit greater stability as chelating agents...

Published: 4/22/2025 | Inventor(s): Francois Guerard, Yong-Sok Lee, Martin Brechbiel

Keywords(s): imaging agent, PET, zirconium-89

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Research Materials

Intelligent, Adaptive, and Multimodal Data-Driven Epileptogenic Zone Identification and Cognitive Function Mapping Platform (UCLA Case No. 2023-214)

Summary: UCLA researchers in the Departments of Neurology and Electrical and Computer Engineering have developed a data-driven, deep learning-powered software platform to localize epileptogenic tissues in the brain and cognitively map nearby regions. Background: According to the World Health Organization, 50 million people around the world suffer...

Published: 8/1/2025 | Inventor(s): Vwani Roychowdhury, Hiroki Nariai, Richard Staba, Yipeng Zhang

Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, Artificial Neural Network, Biomonitoring, Brain Mapping, Condition monitoring, Deep Learning, Digital Health, Digital Pathology, Electroencephalography (EEG), Epilepsy, Hospital Systems And Devices, Medical Device, Medical Devices and Materials, Monitoring (Medicine), Monitoring And Recording Systems, MRI, PET, remote monitoring, Software, Software & Algorithms

Category(s): Software & Algorithms, Software & Algorithms > Digital Health, Software & Algorithms > Artificial Intelligence & Machine Learning, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems

A Novel Reagent for Labeling PET Tracers at Trifluoromethyl Groups

The molecular imaging technique of positron emission tomography (PET) is an increasingly important tool in biomedical research and in drug discovery and development. Many small molecule drugs and potential PET radiotracers carry trifluoromethyl (CF3) groups. Because CF3 groups are generally considered to be metabolically stable, there is a strong interest...

Published: 10/28/2024 | Inventor(s): Mohammad Haskali, Victor Pike

Keywords(s): :, [11C]Fluoroalkanes, Added, AGENT, LABELING, Method, No-Carrier, PET, Producing, Radiotracers, VAXXXX, VCXXXX, VDXXXX, VEXXXX, VNXXXX, WBXXXX, WIXXXX, XDXXXX, XFXXXX, YAXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Geriatrics, Application > Software / Apps, TherapeuticArea > Psychiatry/Mental Health, TherapeuticArea > Neurology, Application > Medical Devices, TherapeuticArea > Immunology

Evans Blue Dye Derivatives for Serum Albumin Labeling

The invention is an imaging agent and method of use for imaging blood pools and the lymphatic system. The imaging agent binds with high affinity to serum albumin, the most abundant serum protein, and can be tagged with several isotopes making it suitable for magnetic resonance imaging or positron emission tomographic imaging. To date, only very few...

Published: 9/11/2025 | Inventor(s): Lixin Lang, Gang NIU, Xiaoyuan (Shawn) Chen

Keywords(s): Albumin, BLUE, CA2BXX, Evans Blue, fluorene-18, IA4AXX, LABELED, LABELING, Listed LPM Fenn as of 4/15/2015, Magnetic Resonance, PET, Pet imaging, positron emission, Positron-Emitting, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PXXXXX

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Application > Consumer Products, Application > Diagnostics, Application > Research Materials

Small Molecule Imaging of Fungi by Positron Emission Tomography Scanning

This technology relates to the field of radioactive, isotopically-labeled calcofluor derivatives and uses of such compounds to detect a broad spectrum of filamentous fungi including pathogenic species such as Aspergillus and Mucorales, by diagnostic imaging methods such as positron emission tomography (PET) scanning. Aspergillosis and other filamentous...

Published: 10/28/2024 | Inventor(s): Dale Kiesewetter, John Panepinto, Jin Qiu, Peter Williamson

Keywords(s): DA1XXX, FUNGI, IMAGING, Listed LPM Fenn as of 4/15/2015, MOLECULE, PET, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SCANNING, Small, VKXXXX, WBXXXX, XFXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Medical Devices, Application > Software / Apps, Application > Diagnostics, Application > Non-Medical Devices

Photoinduced Electron Transfer Fluorescent Primer for Nucleic Acid Amplification

CDC scientists have developed a rapid and cost-efficient method for generating fluorescently labeled primers for PCR and real-time PCR. At present, fluorescent primers are useful for detecting and identifying microbes and specific nucleic acid sequences, amplifying nucleic acids for pyro-sequencing, determining the levels of gene expression, and many...

Published: 4/24/2025 | Inventor(s): Vincent Hill, Brian Holloway, Jothikumar Narayanan

Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC4XXX, AC5XXX, AC6XXX, Acid, ACXXXX, AE1BXX, AG1XXX, amplification, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, ELECTRON, Nucleic, OID-NCEZID-DFWED, PET, PHOTOINDUCED, PRIMER, TRANSFER, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VNXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WHXXXX, WIXXXX, WMXXXX, XBXXXX, XCXXXX, XEXXXX, XHXXXX, YBXXXX

Positron Emission Tomography Guided Delivery of Mitochondrial Complex I Inhibitors (UCLA Case No. 2020-163)

UCLA researchers in the David Geffen School of Medicine Division of Pulmonary and Critical Care Medicine have developed a novel use of the positron emission tomography (PET) tracer [18F]FBnTP to guide the delivery of mitochondrial complex I inhibitors for the treatment of lung cancers.BACKGROUND: The mitochondria are essential regulators of cellular...

Published: 7/17/2025 | Inventor(s): David Shackelford, Seyed Saman Sadeghi Hosseini, Milica Momcilovic

Keywords(s): Diagnostic Markers & Platforms, Imaging, Medical Imaging, PET, Respiratory & Pulmonary

Category(s): Medical Devices > Medical Imaging > PET, Therapeutics > Oncology, Therapeutics > Respiratory And Pulmonary

2017-450 MICROSCALE DEVICE AND METHOD FOR PURIFICATION OF RADIOPHARMACEUTICALS

Microscale Device and Method for Purification of RadiopharmaceuticalsTech ID: 30310 / UC Case 2017-450-0SUMMARYUCLA researchers from the Departments of Molecular & Medical Pharmacology and Bioengineering have developed a novel method for the purification of radiopharmaceuticals for the on-demand production of positron emission tomography (PET) tracers.BACKGROUNDPositron...

Published: 7/17/2025 | Inventor(s): Michael van Dam, Seunghyun Noel Ha, Jason Jones, Jimmy Ly, Stephen Liu, Shilin Cheung

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Medical Imaging, PET

Category(s): Diagnostic Markers, Medical Devices > Medical Imaging, Platforms > Diagnostic Platform Technologies, Medical Devices > Medical Imaging > PET

2017-380 DEVICE AND METHOD FOR MICROSCALE CHEMICAL REACTIONS

Device and Method for Microscale Chemical ReactionsTech ID: 30291 / UC Case 2017-380-0SUMMARYUCLA researchers in the Departments of Bioengineering and Molecular and Medical Pharmacology have developed a passive microfluidic reactor chip with a simplified design that is less costly than existing microfluidic chips.BACKGROUNDAlthough positron emission...

Published: 7/17/2025 | Inventor(s): Michael van Dam, Jia Wang

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Medical Imaging, PET

Category(s): Diagnostic Markers, Medical Devices > Medical Imaging, Platforms > Diagnostic Platform Technologies, Medical Devices > Medical Imaging > PET

2017-185 METHOD FOR CONCENTRATION AND FORMULATION OF RADIOPHARMACEUTICALS

Method For Concentration And Formulation Of RadiopharmaceuticalsTech ID: 30269 / UC Case 2017-185-0SUMMARYResearchers at the UCLA Department of Medical and Molecular Pharmacology have developed a compact microfluidic device that is able to achieve rapid concentration and/or reformulation of PET tracers after HPLC purification.BACKGROUNDPositron emission...

Published: 7/17/2025 | Inventor(s): Michael van Dam, Philip Hongsean Chao

Keywords(s): Life Science Research Tools, Medical Imaging, Microfluidics And Mem's, PET

Category(s): Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > PET

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