Search Results - metabolite

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Use of the Ketamine Metabolite (R,6R)-hydroxynorketamine in Depression
This technology includes the identification and use of a ketamine metabolite, (2R,6R)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone (HNK), for the treatment of depression. Ketamine is an NMDA receptor antagonist that exerts a rapid and sustained antidepressant and anti-suicidal effect. However, even low doses of ketamine has addictive and psychomimetic...
Published: 10/28/2024   |   Inventor(s): Todd Gould, Irving Wainer, Carlos Zarate, Ruin Moaddel, Patrick Morris, Panos Zanos, Craig Thomas
Keywords(s): 2R, 6R-hydroxynorketamine, depression, Ketamine, METABOLITE, VEXXXX, VNXXXX, WIXXXX, WKXXXX
Category(s): TherapeuticArea > Neurology, TherapeuticArea > Psychiatry/Mental Health, Application > Therapeutics, Application > Research Materials
Novel Magnetic Resonance Spectroscopy (MRS) Technique to Quantify Brain Metabolites
With respect to quantification of metabolites in the brain, conventional methods of magnetic resonance spectroscopy (MRS) yield results that are highly variable and highly dependent on the sequence type being applied. This invention describes a novel MRS technique that involves preparing longitudinal steady states at different flip angles using trains...
Published: 10/28/2024   |   Inventor(s): Jun Shen, Linqing Li
Keywords(s): AAXXXX, DRIVEN, IMAGING, ImagingMRI, LINEAR, METABOLITE, MRI, NCXXXX, Probing, QUANTIFICATION, Relaxation, RF, States, Steady, VCXXXX, VEXXXX, Vivo, VNXXXX, WBXXXX, XFXXXX, YAXXXX, YDXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Neurology, TherapeuticArea > Psychiatry/Mental Health, Application > Non-Medical Devices, TherapeuticArea > Oncology, Application > Software / Apps, Application > Medical Devices, Application > Diagnostics, Application > Research Materials
Pyruvate Kinase M2 Activators for the Treatment of Cancer
This technology describes a series of small-molecule activators of the pyruvate kinase M2 isoform (PK-M2). Pyruvate kinase (PK) is a critical metabolic enzyme that catalyzes the last step of the glycolytic pathway. It exists in several isoforms with different patterns of tissue expression. One isoform, PK-M2, is expressed in cells with a high rate...
Published: 11/5/2024   |   Inventor(s): Jian-kang Jiang, Matthew Boxer, Min Shen, Douglas Auld, Craig Thomas
Keywords(s): Activator, ACTIVATORS, CANCER, CBXXXX, CXXXXX, Dimer, IBXXXX, ISOFORM, IXXXXX, M2, METABOLIC, METABOLITE, PK, PKM2, PK-M2, Proliferation, PYRUVATE, pyruvate kinase, small molecule, Tetramer, tumor
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials
2-Hydroxyglutarate Enantiomer Detection in Complex I Deficient Encephalopathy
Reference #: 01572 The University of South Carolina is offering licensing opportunities for 2-Hydroxyglutarate Enantiomer Detection in Complex I Deficient Encephalopathy Background: There are genetic diseases that impair the function of the mitochondria, they do not make enough ATP (energy) for demanding tissues such as the brain and muscles. One...
Published: 3/21/2024   |   Inventor(s): Norma Frizzell
Keywords(s): 2-hydroxyglutarate, electron transport chain, enantiomer, Leigh Syndrome, metabolic flexibility, metabolite, mitochondria, mitochondrial disease
Category(s): Health Sciences, Biomedical and Life Sciences