Highly Sensitive RSV Reporter Tools for Anti-Viral Drug Discovery

Description

This technology is a series of innovative RSV reporter tools for high throughput screening of anti-viral drug candidates. Our reporter tools offer innovative solutions for RSV drug discovery and vaccine development, with improved sensitivity and robustness compared to conventional fluorescent assays. Additionally, these tools are simplified, shortened versions of the viral genome, allowing safer RSV research in lower BSL environments.

RSV is a leading cause of respiratory infections in infants, young children, and elderly worldwide. In the U.S. alone, there are 60,000–160,000 hospitalizations in adults over 65 years old each year. Due to the limited duration of effect, high cost, and suboptimal anti-inflammatory properties of existing RSV vaccines, there is a pressing need to further develop enhanced RSV vaccines.

Benefits

Safer: Does not require high-level biosafety containment facilities.
Improved Sensitivity: High sensitivity compared to conventional fluorescent assays, allowing detection of low concentrations of RSV virus in samples
High-Throughput Screening: Can be used in high throughput screening for RSV vaccine and drugs, allowing processing of large numbers of samples with reduced cost and lab labor per sample
Quantification of Viral Activity: Enables precise quantification of viral activity