Search Results - wenwei+huang

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Using FDA-approved Small Molecule Drug Reserpine and related compounds (especially Halofantrine) To Protect Photoreceptors In Inherited Retinal Degenerations And Age-Related Macular Degeneration
Summary: The National Eye Institute seeks research co-development partners and/or licensees for a therapy using an FDA-approved small molecule drug reserpine (and related compounds especially halofantrine) that prevents photoreceptor cell death in retinal degenerations. Description of Technology: Inherited Retinal Degenerations (IRD), such as Leber...
Published: 9/18/2024   |   Inventor(s): Anand Swaroop, Yu Holly Chen, Samantha Papal, Anupam Mondal, Manju Swaroop, Wei Zheng, Gregory Tawa, Wenwei Huang, Zhiji Luo
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat
Metabolic activity diffusion imaging (MADI): dye-free, high-resolution MRI metabolic imaging
Summary The current technology is a contrast agent-free method of metabolic imaging based on detection of Na/K ATPase activity with MRI, that provides significantly higher resolution than current approaches such as PET. Technology Overview Measuring metabolic activity in vivo can facilitate diagnoses of disease states and therapeutic responses....
Published: 1/15/2024   |   Inventor(s): Gregory Wilson, Jeffrey Maki, Charles Springer, Jr., Xin Li, William (Bill) Rooney, Brendan Moloney, Wei Huang, Tom Barbara, Eric Baker
Keywords(s): Diagnostics, Imaging, Imaging - MRI, Software, Software - Other
Category(s): Imaging, Software
Repurposing CDK Inhibitors for the Treatment of Zika Virus Infection
This invention includes the discovery and use of a group of CDK inhibitors that were found during a drug repurposing screen designed to find compounds that inhibit Zika virus caused cell death. The identified CDK inhibitors have all previously been used in clinical trials for other diseases, potentially reducing the long time course needed for new drug...
Published: 7/25/2024   |   Inventor(s): Ruili Huang, Miao Xu, Wenwei Huang, Hengli Tang, Emily Lee, Cheng YiChen, Yi Zhou, Hongjun Song, Guo-Li Ming, Zhexing Wen, Wei Zheng
Keywords(s): CDK, Infection, Inhibitors, Repurposing, treatment, VEXXXX, virus, VLXXXX, WIXXXX, WKXXXX, Zika
Category(s): TherapeuticArea > Neurology, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials
Novel ACRV1/ALK2 Inhibitors and Methods for Inhibiting BMP Signaling for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)
This technology includes the identification and use of novel ACRV1/ALK2 inhibitors for the treatment of fibrodysplasia ossificans progressiva (FOP), an autosomal-dominant rare disease that affects one person in every 1-2 million. FOP is characterized by malformation of the great (big) toes during embryonic development and by progressive heterotopic...
Published: 7/25/2024   |   Inventor(s): Jian-kang Jiang, Khalida Shamim, Philip Sanderson, Wei Zheng, Xiuli Huang, Gregory Tawa, Asaf Alimardanov, Arthur Lee, Junfeng Huang, Wenwei Huang
Keywords(s): ALK2, BMP, INHIBITING, Inhibitors, Methods, Novel, SIGNALING, VGXXXX, WIXXXX, WKXXXX, XEXXXX
Category(s): TherapeuticArea > Endocrinology, Application > Therapeutics, Application > Research Materials
Repurposed Use of the Alkaloids Emetine and Cephaeline to Treat Zika Virus Infection
This technology includes the use of two related compounds, Emetine and Cephaeline, as a potent inhibitor of the Zika virus (ZIKV). Emetine and it's analog Cephaeline were identified in a high-throughput assay aimed at identifying anti-ZIKV compounds. Both Emetine and Cephaeline are potent inhibitors of ZIKV infection in cell culture, and Emeline is...
Published: 7/25/2024   |   Inventor(s): Emily Lee, Wei Zheng, Miao Xu, Ruili Huang, Shu Yang, Wenwei Huang, Khalida Shamim, Hao Li, Hengli Tang
Keywords(s): compounds, Emetine, Flavivirus, Infection, Prevention, treatment, VLXXXX, WIXXXX, WKXXXX
Category(s): Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials
Novel Small Molecule Antimalarials for Elimination of Malaria Transmission
The transmission of malaria begins with injection of sporozoites into a human from the bite of a female anopheles mosquito, which initiates the malarial life cycle in humans. When a mosquito bites an infected human, the ingested male and female malaria gametocytes fuse to form a zygote that eventually becomes an oocyst. Each oocyst produces thousands...
Published: 7/25/2024   |   Inventor(s): Wei Zheng, Seameen Dehdashti, Noel Southall, Wenwei Huang, Wei Sun, Takeshi Tanaka, John McKew
Keywords(s): compounds, DB2XXX, Gametocytocidal, Identification, Malaria, Novel, VOXXXX, WKXXXX, XHXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, ResearchProducts > Research Equipment, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Consumer Products
Novel Small Molecule Inhibitors for the Treatment of Huntington’s Disease
This technology is a collection of small molecules screened for their ability to prevent or reduce the cytotoxic effects of the protein, Huntingtin. Huntington's disease is a neurodegenerative disorder due to a dominantly acting expansion of a CAG trinucleotide repeat in exon 1 of the Huntington (HTT) gene resulting in production of the altered (mutant)...
Published: 7/25/2024   |   Inventor(s): Joshua McCoy, Samarjit Patnaik, Steven Titus, Wei Zheng, Noel Southall, Wenwei Huang, Juan Marugan
Keywords(s): ANALOGUES, Disease, HUNTINGTON'S, IB6XXX, IBXXXX, IXXXXX, NCTT, Novel, Thio-ether, treatment
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Reproductive Health, Application > Research Materials, Application > Diagnostics
Leukemia inhibitory factor- Protective role for radiation/chemo-induced gut syndrome and GVHD
Invention Summary: Currently there is no effective therapy for prevention or treatment of radiation therapy-induced gastrointestinal (GI) tract injury This is also true for Graft-versus-host disease (GVHD) which remains a major complication after allogeneic hematopoietic stem cell transplantation, a widely-used therapy for hematologic malignancies...
Published: 10/4/2022   |   Inventor(s): Wenwei Hu, Zhaohui Feng, Jianming Wang, Huaying Wang
Keywords(s): Anti-cancer, Gastrointestinal disease, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Therapeutics
Processing Technique for Ceramic- based Energy Conversion and Storage Devices
Due to rising carbon emissions, extreme weather events and other environmental threats, the demand for alternative energy sources is greater than ever. Therefore, businesses and communities are asking for three things: more affordable electricity, more resilient power, and cleaner energy. Fuel cells, electrolysis cells, membrane reactors, and solid-state...
Published: 1/11/2024   |   Inventor(s): Hai Xiao, Jianhua Tong, Fei Peng, Kyle Brinkman, Jincheng Lei, Yuzhe Hong, Hua Huang, Shenglong Mu, Rajendra Bordia
Keywords(s):  
Category(s): Manufacturing
Hybrid Plasmonic Platform for Directing and Controlling Nanostructure Growth
Low-Heat, Bottom-Up Approach Can Produce Metal, Polymer or Bio-Molecule Structures for Catalysis, Biosensors, Electronic Devices and MoreThis surface plasmon mediated chemical solution deposition method uses surface plasmon resonance to deposit nanoparticles in the liquid phase at room temperature to direct and control nanostructure growth. Plasmonic...
Published: 6/27/2021   |   Inventor(s): Wei Wei, Jingjing Qiu
Keywords(s): Catalysts, nanoparticle synthesis, Plasmonic, Thin Films
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Materials
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