Search Results - hongjun+song

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Repurposing CDK Inhibitors for the Treatment of Zika Virus Infection
This invention includes the discovery and use of a group of CDK inhibitors that were found during a drug repurposing screen designed to find compounds that inhibit Zika virus caused cell death. The identified CDK inhibitors have all previously been used in clinical trials for other diseases, potentially reducing the long time course needed for new drug...
Published: 7/25/2024   |   Inventor(s): Ruili Huang, Miao Xu, Wenwei Huang, Hengli Tang, Emily Lee, Cheng YiChen, Yi Zhou, Hongjun Song, Guo-Li Ming, Zhexing Wen, Wei Zheng
Keywords(s): CDK, Infection, Inhibitors, Repurposing, treatment, VEXXXX, virus, VLXXXX, WIXXXX, WKXXXX, Zika
Category(s): TherapeuticArea > Neurology, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials
Application of human 3D brain organoids in regenerative medicine and drug testing
Problem: Current drug discovery strategies often utilize cell lines and animal models for compound development, drug screening, efficacy testing, and establishing dose-responses. However, such model systems are often limited, particularly for brain disorders and cancers. Traditional cell culture systems can unintentionally alter physiological properties...
Published: 2/9/2024   |   Inventor(s): Hongjun Song
Keywords(s):  
Category(s): Technology Classifications > Research Tools & Reagents