Search Results - richard+plemper

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Recombinant Respiratory Syncytial Virus (RSV) Firefly Luciferase Reporter Strain
Application Modified recombinant syncytial virus (RSV) strain expressing a bioluminescent reporter protein for high throughput screening and vaccine development. Key Benefits Provides a new high throughput screening tool for RSV vaccine development and drug discovery. Firefly luciferase based assays show better signal-to-noise than fluorescence-based...
Published: 9/26/2024   |   Inventor(s): Richard Plemper, Martin Moore
Keywords(s): Immunology/Inflammation, Microbiology/Infectious Diseases, Respiratory
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Vaccines
Assay for Non-Nucleoside Inhibitors of the Measles and Nipah Viruses
Application A cell-based assay to screen for inhibitors of the measles virus (MV). Highly active compounds have been identified and analogs have been synthesized and evaluated. Key Benefits Potent (sub-nM range), non-peptidic, non-nucleosidic compounds. Robust, cell-based, high-throughput screening assay. Technical Summary Vaccination serves...
Published: 9/26/2024   |   Inventor(s): Richard Plemper, James Snyder, Aiming Sun
Keywords(s): Assay, Microbiology/Infectious Diseases, Rare/Orphan Diseases
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery, TechPub Algolia > Research Tools
Respiratory syncytial virus (RSV) Reporter Plasmid for High Throughput Drug Screening
Application Bioluminescence reporter for high throughput respiratory syncytial virus (RSV) drug discovery. Key Benefits Simple luciferase readout marker indicates RSV replication activity. Market Summary RSV is a ubiquitous respiratory pathogen worldwide. It is the most common cause of severe lower respiratory tract disease among infants and young...
Published: 9/26/2024   |   Inventor(s): Martin Moore, Anne Hotard (Lopez-Ona), Richard Plemper
Keywords(s): Immunology/Inflammation, Microbiology/Infectious Diseases, Respiratory
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Drug Discovery, TechPub Algolia > Vaccines
Respiratory Syncytial Virus (RSV) Luminescent Reporter Strain
Application Modified respiratory syncytial virus (RSV) expressing a bioluminescent reporter protein for high throughput screening, vaccine development, and drug discovery. Plasmid encoding virus also available. Key Benefits Provides a new high throughput screening tool for RSV vaccine development and drug discovery. Bioluminescent assays outperform...
Published: 9/26/2024   |   Inventor(s): Richard Plemper, Martin Moore
Keywords(s): Immunology/Inflammation, Microbiology/Infectious Diseases, Respiratory
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Vaccines
Small Molecule Non-Nucleoside Inhibitors of the Measles Viruses
Application Small molecule measles virus RNA Dependent RNA Polymerase (RDRP) inhibitors. Key Benefits Potent (nM) non-nucleoside small molecule inhibitors of the measles virus RDRP protein. No current drug therapy for measles. Market Summary The target market for this therapeutic agent is in the developing world where measles has been known...
Published: 9/26/2024   |   Inventor(s): Richard Plemper, James Snyder, Aiming Sun, John Maina Ndungu, Jeong-Joong Yoon
Keywords(s): Microbiology/Infectious Diseases, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Small Molecule Inhibitors Show Promise with RNA Viruses
Application Potent small molecule inhibitors of RNA viruses that cause many highly contagious and dangerous diseases such as canine distemper, RSV, influenza, and measles. Key Benefits Inhibits measles, canine distemper, human parainfluenza, and influenza A viruses. May be used for the management of a disease and for rapid control of possible...
Published: 7/30/2024   |   Inventor(s): Richard Plemper, James Snyder, Aiming Sun, John Maina Ndungu, Jeong-Joong Yoon
Keywords(s): Microbiology/Infectious Diseases, Small Molecule
Category(s): TechPub Algolia > Therapeutics