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Search Results - roger+nani
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A New Class of Stable Heptamethine Cyanine Fluorophores and Biomedical Applications Thereof
Abstract: Heptamethine cyanines are among the most widely used near-IR fluorophores. The near-IR range (between about 650 nm and 900 nm) is very useful for imaging applications due to the absence of background autofluorescence. Despite extensive use, many of these fluorophores suffer from chemical instability. Specifically, most of the current and commonly...
Published: 4/8/2024
|
Inventor(s):
Martin Schnermann
,
Roger Nani
,
James Shaum
Keywords(s):
Antibody labeling
,
DYE
,
Fluorescence-activated cell sorting (FACS)
,
Fluorophore
,
Heptamethine Cyanines
,
IMAGING
,
Imaging Microscopy
,
Imaging reagent
,
MICROSCOPY
,
near-IR fluorophores
,
Optical-Guided Surgery
Category(s):
TherapeuticArea > Oncology
,
Collaboration Sought > Licensing
,
Application > Research Materials
,
Collaboration Sought > Collaboration
Near-IR Light-Cleavable Antibody Conjugates and Conjugate Precursors
Abstract: This invention describes a general way to trigger the release of a bioactive small molecule from a targeting antibody. The key “trigger” is a fluorescent linker that is chemically disassembled upon irradiation with light in the near-IR range (~800 nm). This linker technology is a dramatic step forward for the field. The molecules can be tracked...
Published: 4/8/2024
|
Inventor(s):
Martin Schnermann
,
Alexander Gorka
,
Hisataka Kobayashi
,
Roger Nani
Keywords(s):
ADC
,
Antibody-drug Conjugate
,
Chemical linkers
,
Fluorescent linker
,
PDT
,
personalized medicine
,
Photodynamic therapy
,
Targeted drug release
,
Targeted therapy
Category(s):
TherapeuticArea > Oncology
,
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
Application > Therapeutics