Search Results - hisataka+kobayashi

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Combination of Near Infrared Photoimmunotherapy Targeting Cancer Cells and Host-Immune Activation
Abstract: Common methods of cancer therapy largely rely on either direct killing of cancer cells or activation of the host immune response to do so, but not both. A recently developed treatment of tumors uses an antibody/photo-absorber, Ab-IR700, with near infrared photoimmunotherapy (NIR-PIT), to selectively kill IR700-bound and NIR-light-exposed cancer...
Published: 9/19/2024   |   Inventor(s): Hisataka Kobayashi, Peter Choyke
Keywords(s): antibody-IR700, Combination Therapy, Immunomodulators, Immunotherapy, Kobayashi, Metastasis, Near-Infrared Photo Immunotherapy, NIR-PIT, Photochemical, Tumor Inhibition
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Near-IR Light-Cleavable Antibody Conjugates and Conjugate Precursors
Abstract: This invention describes a general way to trigger the release of a bioactive small molecule from a targeting antibody. The key “trigger” is a fluorescent linker that is chemically disassembled upon irradiation with light in the near-IR range (~800 nm). This linker technology is a dramatic step forward for the field. The molecules can be tracked...
Published: 4/8/2024   |   Inventor(s): Martin Schnermann, Alexander Gorka, Hisataka Kobayashi, Roger Nani
Keywords(s): ADC, Antibody-drug Conjugate, Chemical linkers, Fluorescent linker, PDT, personalized medicine, Photodynamic therapy, Targeted drug release, Targeted therapy
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics
Removal of Selected Proteins Using Light Energy: Photoimmunotherapy
Abstract: Researchers at the NCI  Laboratory of Molecular Theranostics and the Molecular Imaging Program have developed a new method to modify, isolate and remove a single chemically-labeled molecule or a cluster of proteins associated with the chemically-labeled protein. The chemical label can be an antigen-antibody complex. This discovery is based...
Published: 4/8/2024   |   Inventor(s): Hisataka Kobayashi, Martin Schnermann, Peter Choyke
Keywords(s): AGGREGATION, Fluorophore, IR700, photoactivation, Photoimmunotherapy
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Oncology