Search Results - caspi

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Interleukin 24 (IL-24) to treat inflammatory diseases
Abstract: Proinflammatory T-helper 17 cells (Th17) play important roles in host immune defense against infection, but uncontrolled activation of these cells, known as the Th17 response, may cause autoimmune and autoinflammatory diseases (uveitis, multiple sclerosis, rheumatoid arthritis, and Crohn’s disease) through the effects of Th17 lineage...
Published: 4/8/2024   |   Inventor(s): Rachel Caspi, Mary Mattapallil, Reiko Yamane, Wai Po Chong
Keywords(s): Caspi, Crohn’s disease, IL-24, inflammatory disease, interleukin 24, Multiple sclerosis, National Eye Institute, NEI, proinflammatory T-helper 17 cell, RHEUMATOID ARTHRITIS, Th17, uveitis
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology
Use of Interleukin (IL)-34 to Treat Retinal Inflammation and Neurodegeneration
Abstract: Interleukin (IL)-34 is a homodimer that is produced mainly by keratinocytes, neuronal cells and regulatory T cells (Tregs). It is believed to play important roles in chronic inflammation and the homeostasis of microglia. Currently, there is no effective treatment for many types of retinal degeneration. An improved treatment of autoimmune uveitis...
Published: 4/8/2024   |   Inventor(s): Rachel Caspi, Mary Mattapallil, Zhijian Wu
Keywords(s): AAV Vector, Caspi, GENE THERAPY, IL-34, inflammatory disease, Inherited Retinal Dystrophies, Interleukin 34, National Eye Institute, NEI, NEURODEGENERATION, Photoreceptor Death, Retinal degeneration, Retinal Inflammation, uveitis
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Immunology