Search Results - benjamin+keselowsky

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Anchored Enzymes to Treat Inflammatory Diseases

Prolongs Residence of Immunosuppressive Enzymes at Sites of Inflammation Via Minimally-Invasive Injection This bifunctional fusion protein resets the immune system to promote healthy tissue function by anchoring enzymes to the site of inflammation. Biologic drugs used to treat inflammatory diseases are a market that exceeds $30 billion annually. Available...

Published: 6/27/2021 | Inventor(s): Benjamin Keselowsky, Gregory Hudalla, Evelyn Bracho-Sanchez, Shaheen Farhadi, Margaret Fettis, Sabrina Freeman, Antonietta Restuccia

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Category(s): Technology Classifications > Engineering > Materials, Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Human Health Care > Therapeutics

Cell-based Arrays for Screening Combination Drug Efficacy for Personalized Cancer Therapy

Arrays Require Just a Small Number of Rare Cells to Determine Best Combination of Drugs for Patient TreatmentThese cell-based arrays use a small sampling of cells to help isolate and identify a patient’s sensitivity to chemotherapeutic drugs in vitro, potentially personalizing treatment of cancer. The cancer stem cell hypothesis postulates that...

Published: 6/27/2021 | Inventor(s): Edward Scott, Benjamin Keselowsky, Abhinav Acharya, Emina Huang, Matthew Carstens

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Category(s): Technology Classifications > Others > Others

Antigen-Specific Tolerizing Treatment for Multiple Sclerosis

Localized, Antigen-Specific, Immunomodulatory Treatment for Multiple Sclerosis Without Global ImmunosuppressionThis antigen-specific microparticle therapy is a robust and highly efficacious, localized treatment for multiple sclerosis (MS) without provoking global immunosuppression. MS is the most common, potentially disabling, neurological disease typically...

Published: 7/18/2023 | Inventor(s): Dorina Avram, Benjamin Keselowsky

Keywords(s): antigen specific, microparticle deliver, multiple sclerosis, myelin, Therapeutic, Therapy

Category(s): Technology Classifications > Human Health Care > Therapeutics

Polymeric Microparticle Blends for Enhanced Cytosolic Drug Delivery

Increase Therapeutic Effects of Drug Delivering MicroparticlesDrug delivery systems utilizing microparticle blends that incorporate poly(propylacrylic acid) into poly(lactide-co-glycolide) improve intracellular cytosolic delivery of bioactive molecules. The therapeutic potential of bioactive molecules delivered by microparticles is reduced considerably...

Published: 6/27/2021 | Inventor(s): Benjamin Keselowsky, Jamal Lewis, Lawrence Fernando, Lirong Yang, Craig Duvall, Brian Evans

Keywords(s): Drug Delivery, Drug Delivery (controlled), Drug Delivery into Cells, Lysosomal ph, Nano/Micro Particles

Category(s): Technology Classifications > Human Health Care > Drug Delivery

Microarray for Efficient, Inexpensive Testing on Rare Patient-Derived Cells

Reduces Costs by Allowing Researchers to Test Multiple Agents SimultaneouslyThis cell-based microarray allows testing of a wide range of biological or pharmaceutical agents on small numbers of cells from rare populations. Patient-derived cells such as cancer cells, stem cells and precancerous cells are difficult and expensive to obtain. Inefficient...

Published: 6/27/2021 | Inventor(s): Edward Scott, Benjamin Keselowsky, Abhinav Acharya, Emina Huang, Matthew Carstens

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Category(s): Technology Classifications > Human Health Care > Others

Orthopedic Implants that are Safely Absorbed after the Body has Healed

Promotes new bone and prevents stress shielding to speed recoveryThese nontoxic biomedical implants stabilize fractures or temporarily assist the healing of damaged bone. The body safely absorbs these devices once they are no longer needed. Composed of a magnesium alloy that contains calcium and strontium, these implants not only mimic natural bone's...

Published: 6/27/2021 | Inventor(s): Benjamin Keselowsky, Michele Manuel, Harpreet Brar, Malisa Sarntinoranont, Ida Svensson Berglund

Keywords(s): Bioabsorbable, biocompatible, Composite, dissolution, Drug-eluting, Magnesium, Medical Device, Orthopedic, Strontium

Category(s): Technology Classifications > Engineering > Materials, Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Medical Devices > Consumable