Search Results - david+issadore

6 Results Sort By:
Single-Step Wettability Patterning for Microfluidic Generation of Emulsions
Method to transfer wettability properties of a mold to microfluidic devices, defining hydrophobic/hydrophilic regions through variable perfluoropolyether concentration. Problem: Current wettability patterning methods involve sequentially flowing chemicals into channels, blocking areas where treatment is not desired. These multi-step methods are labor...
Published: 7/23/2024   |   Inventor(s): Daeyeon Lee, David Issadore, Jingyu Wu
Keywords(s): Microfluidics
Category(s): Technology Classifications > Chemical Processes and Synthesis
Effective Anti-Fouling Surface Coating of Microfluidic Mixing Devices for Robust mRNA Lipid Nanoparticles (LNP) Manufacturing
Employment of omniphobic, thin-layer perfluorocarbon (TLP) coating to prevent fouling and clogging in microfluidic mixing devices during mRNA LNP formulations. Problem: Lipid nanoparticle (LNP)-based delivery systems for mRNA and other therapeutics recently gained popularity because of their application in the Pfizer/BioNTech and Moderna COVID-19 vaccines....
Published: 7/15/2024   |   Inventor(s): Daeyeon Lee, Yoon-Ho Hwang, David Issadore
Keywords(s): Bioengineering, Microfluidics
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Materials
Ultrasensitive, High-Throughput, Single-Scale Detection of Extracellular Vesicles
An optofluidic platform to detect extracellular vesicles (EVs) at the single-particle level by parallelizing droplet generation and analysis of EVs. Problem: Extracellular vesicles (EVs) are lipid bound nanomaterials carrying various molecular cargo that can be representative of their cells of origin. EVs play a critical role in intercellular communication...
Published: 2/26/2024   |   Inventor(s): David Issadore, Zijian Yang
Keywords(s): Bioengineering, Microfluidics, Optics & Photonics , Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Pico-Washing: High Throughput Droplet Fluid-Exchange for Microfluidic Platforms
Device that simultaneously injects fluid into and removes fluid from droplets in flow. Problem: Droplet microfluidic technology is rapidly developing, unlocking newer high-throughput approaches in various fields including single-cell transcriptomics, genomics, and proteomics. One unit operation that remains underdeveloped in droplet microfluidics...
Published: 10/16/2023   |   Inventor(s): David Issadore, Michael Siedlik
Keywords(s): Bioengineering, Immunology, Infectious Disease, Microfluidics, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents, Technology Classifications > Hardware & Components, Technology Classifications > Testing & Measurement
Microfluidic device for large-scale production of lipid nanoparticles
​A scalable, parallelized, multi-channel microfluidic device for generating lipid nanoparticles. Problem: Lipid nanoparticles are a promising delivery technology for RNA therapeutics and vaccines. However, there is a lack of formulation strategies that can produce nanoparticles with precisely defined properties that have scalable throughputs ranging...
Published: 10/16/2023   |   Inventor(s): Michael Mitchell, David Issadore, Sarah Shepherd, Sagar Yadavali
Keywords(s): Bioengineering, Drug Delivery, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Materials
Advanced platform for integrated circuits and microfluidic integration
Problem: Microfluidics allow for significantly improved analyte detection. Unfortunately, current techniques to incorporate low cost IC methods and novel microfluidic methods suffer from an inherent mismatch in device sizes (mm vs cm). To date, techniques developed have either been expensive, time consuming, or unreliable. Solution: This technology...
Published: 10/16/2023   |   Inventor(s): David Issadore
Keywords(s): Microfluidics
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Medical Devices, Technology Classifications > Materials