Search Results - drug+target+identification

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Human Brain Proteins with Evidence Consistent with Causality of Alzheimer’s and Depression
Application Research and therapeutic targets for Alzheimer’s disease, depression, and other neurological conditions mediated by protein expression in the brain. Key Benefits These findings can be utilized as a research tool to better understand the genetic basis of Alzheimer’s disease. Can also be utilized to develop therapeutics for...
Published: 2/13/2025   |   Inventor(s): Aliza Wingo, Thomas Wingo, Yue Liu, Allan Levey, Nicholas (Nick) Seyfried, Duc Duong
Keywords(s): Drug Target Identification
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Therapeutics
KRAS Mutant Protein-Protein Interaction Targets and Inhibitors for Cancer Therapy
Application Immunotherapeutic agent and biosensor for KRASG12V mutation in tumor cells. Key Benefits First in class, targeted immunotherapy for patients presented with KRASG12V mutation. Attenuates immune suppression associated with KRASG12V-positive cancers. Market Summary The KRASG12V mutation, representing 85% of all cancer mutations, is...
Published: 3/28/2025   |   Inventor(s): Haian Fu, Cong Tang, Xiulei Mo
Keywords(s): Drug Target Identification, Enzyme and Protein Research, Immunology and Inflammation Treatments, Oncology Treatments
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
Optimized Carbohydrates for Tumor Targeting
The bleomycins (BLMs) are well-known antineoplastic agents, clinically useful in the treatment of squamous cell carcinomas and malignant lymphomas. The carbohydrate moiety, particularly the disaccharide moiety, of BLM is also known to be highly tumor targeting. Researchers at the Biodesign Institute of Arizona State University have discovered disaccharides...
Published: 2/13/2025   |   Inventor(s): Sidney Hecht, Manikandadas Mathilakathu Madathil, Chandrabali Bhattacharya, Trevor Bozeman, Rakesh Paul, Zhiqiang Yu, Michael Rishel
Keywords(s): Diagnostics, Drug Target Identification, Imaging, Medical Devices and Imaging, Molecular Diagnostics
Category(s): Life Science (All LS Techs), Imaging, Medical Imaging, Pharmaceuticals
Microreactor Array Instrument/Platform
High throughput parallel assays are needed to effectively identify and study biomolecules and their activity. Typically it takes a large number of repeated assays to get statistically significant data for studying biomolecules. However, fewer assays would be needed to get statistically meaningful results if the data were of higher quality. Because of...
Published: 2/13/2025   |   Inventor(s): Peter Wiktor
Keywords(s): Array Techs - Micro, Nano, Gen,Proteomic, Bioassay, Bio-Technology, Detection, Diagnostics, Diffusion, DNA nanotechnology, Drug Discovery, Drug Screening, Drug Target Identification, ELISA, Genomics, Proteomics, Health Monitoring, High Throughput Sensors, Immunology, In situ, In Vitro, Instrumentation, Liquid Handling and Dispensing, MicroArray, Microbiology, Micro-Fluidics, Microreactor, Molecular Diagnostics, Nucleic Acid, Personalized medicine, Pharmaceutical, Polymerase Chain Reaction (PCR), Protein, Protein Assays
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools
Combination Therapy for Increasing Venetoclax Sensitivity in Multiple Myeloma
Application Marker and co-therapy that inhibits succinate dehydrogenase to increase patient response to venetoclax. Key Benefits Co-therapy increases MM sensitivity to venetoclax treatment. Identifies patients who will respond to venetoclax therapy. Market Summary Multiple Myeloma (MM) is a cancer of plasma cells responsible for making antibody...
Published: 3/28/2025   |   Inventor(s): Malathy (mala) Shanmugam, Richa Bajpai
Keywords(s): Biologics, Biomarkers, Drug Target Identification
Category(s): TechPub Algolia > Diagnostics, TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery
Label-free Detection of Small Molecules
The ability to measure molecular binding and interactions is important for understanding many biological processes. Particularly important is detecting the binding of small molecule drugs with their corresponding membrane protein receptors, which currently account for more than half of all drug targets. For effective measurements, purified membrane...
Published: 2/13/2025   |   Inventor(s): Nongjian (nj) Tao, Yan Guan
Keywords(s): Drug Discovery, Drug Screening, Drug Target Identification, Instrumentation, Microscopy, Sensors
Category(s): Bioanalytical Assays, Chemistries & Devices, Imaging, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Mitogenic Oxygenase Regulators for Drug Discovery
Applications Can be used as a target for drug discovery, gene therapy and, to create a diagnostic tool. These applications are relevant to conditions involving inappropriate cell proliferation (e.g., cancer, atherosclerosis), angiogenesis, and tissue damage associated with inflammatory diseases. Technical Summary Reactive oxygen species (ROS) include...
Published: 2/13/2025   |   Inventor(s): John David Lambeth, Guang Cheng
Keywords(s): Cardiology and Vascular Devices, Drug Target Identification, Enzyme and Protein Research, Immunology and Inflammation Treatments, Oncology Treatments
Category(s): TechPub Algolia > Drug Discovery