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Multifunctional Radical Quenchers for Mitochondrial Diseases
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energy effecting defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Arnaud Chevalier, Omar Khdour
Keywords(s):  
Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
Selective Mitochondrial Imaging and Therapeutic Targeting
It is becoming increasingly apparent that mitochondrial dysfunction plays a critical role in numerous human diseases. Yet, there are no approved drugs designed to directly target mitochondria. To develop new therapeutics that target mitochondria, ideally, a mitochondrial targeting moiety would be utilized. Although several functionalities have been...
Published: 1/25/2024   |   Inventor(s): Arnaud Chevalier, Sidney Hecht, Yanmin Zhang, Omar Khdour
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
Methylene Blue and Methylene Violet Analogs as Mitochondrial Therapeutic Agents
Mitochondrial dysfunction has been implicated in a number of diseases, including Alzheimer’s disease (AD), movement disorders, diseases of the cardiovascular system, cancer, diabetes, blindness and deafness. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Membrane-penetrating...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Nishant Visavadiya
Keywords(s): Alzheimer's Disease, Diabetes, Genetic Disorders, Metabolic Disorders, Mitochondrial medicine
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
Methylene Blue and Methylene Violet Analogs as Mitochondrial Therapeutic Agents
Mitochondrial dysfunction has been implicated in a number of diseases, including Alzheimer’s disease (AD), movement disorders, diseases of the cardiovascular system, cancer, diabetes, blindness and deafness. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Membrane-penetrating...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Indrajit Bandyopadhyay
Keywords(s): Alzheimer's Disease, Diabetes, Genetic Disorders, Metabolic Disorders, Mitochondrial medicine, Neurodegenerative Disorders, Parkinson's Disease, Pharmaceutical
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
Multifunctional Radical Quenchers for Mitochondrial Diseases
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energy effecting defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Omar Khdour, Mohammad Alam, Sriloy Dey, Yana Chen, Arnaud Chevalier
Keywords(s): Alzheimer's Disease, Drug Discovery, Mitochondrial medicine, Neurodegenerative Disorders
Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
Alkylaminoquinones as Multifunctional Radical Quenchers
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energetic defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Manikandadas Mathilakathu Madathil, Omar Khdour
Keywords(s): Alzheimer's Disease, CNS Therapeutics, Drug, Mitochondrial medicine, Neurodegenerative Disorders, Neurological Disorders, Pharmaceutical, Therapeutics
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
Multifunctional Radical Quenchers and Simplified Synthesis Routes
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energetic defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Xiaoqing Cai, Omar Khdour
Keywords(s): Mitochondrial medicine, Therapeutics
Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
Multifunctional Radical Quenchers and Simplified Synthesis Routes
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energetic defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Poulami Talukder
Keywords(s): Therapeutics
Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
Reducing Oxidative Stress with Multifunctional Radical Quenchers
Mitochondria are intracellular organelles responsible for a number of metabolic transformations and regulatory functions. They produce much of the ATP employed by eukaryotic cells. They are also the major source of free radicals and reactive oxygen species that cause oxidative stress. Mitochondrial defects are damaging, particularly to neural and...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Jeffrey Armstrong, Omar Khdour, Jun Lu, Pablo Arce
Keywords(s): Therapeutics
Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
Targeted Therapy for Triple-Negative Breast Cancer
Breast cancer is the second leading cause of death in women and is the most common cancer among women worldwide. There are four main breast cancer subtypes, luminal A, luminal B, HER2-positive and triple-negative. Triple-negative breast cancer (TNBC) is highly invasive and has higher rates of metastasis and a worse prognosis. Metastasis of cancer cells...
Published: 9/12/2023   |   Inventor(s): Shengxi Chen, Xiaojiang Cui, Yi Zhang, Sidney Hecht
Keywords(s):  
Category(s): Life Science (All LS Techs), Advanced Materials/Nanotechnology, Cancer, Cancer Therapeutics, Pharmaceuticals
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