Search Results - research+tools

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The Sudden Head Acceleration & Kinetic Encephalopathy (SHAKEn™) Device for Preclinical Modeling of Rotational Brain Injury
­Advantages: User control to adjust the positioning of the body plate (in the x/y plane) to optimize spinal alignment relative to the axis of rotation prior to insult. An aeronautics-grade angular rate sensor for direct measurement of angular velocity and to calculate rotational acceleration of the head. An electric plug to power accelerations...
Published: 7/18/2024   |   Inventor(s): Travis Jackson
Keywords(s): Animal Models, Lab Apparatus, Laboratory Devices, Neuroscience, Research Tools
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience
A microcontroller for easier whole-cell patch clamping on dendrites and axons
Summary The current technology is a microcontroller that allows for the application of controlled negative pressure and simultaneous electrical impulses to make it easier to obtain whole-cell patch clamp recordings on small cellular structures. Technology Overview Whole-cell patch clamping is a technique commonly employed to study the electrical...
Published: 1/30/2024   |   Inventor(s): Stephen Smith, Timur Tsintsadze
Keywords(s): Research Tools, Research Tools - Other
Category(s): Research Tools
Surface Functionalization of Polymers Via Sequential Multiple Plasma Gas Treatments
­Advantages: Improves hydrophobicity and hydrophilicity, optimizing material performance for diverse applications. Benefits medical implants, self-cleaning surfaces, and more, offering broad utility across industries. Preserves core material characteristics while enhancing surface properties, ensuring stability and reliability. Summary: This...
Published: 9/3/2024   |   Inventor(s): NURETTIN SAHINER, Ramesh Ayyala, Venkat Bhethanabotla
Keywords(s): 3D Printing, Anti-Microbials, Biotechnology, Catheters, CleanTech, Construction, Dental Equipment, Environmental Sciences, Food Science, Material Science, Medical Devices, Ocean / Marine Technology, Ophthalmic Equipment, Research Tools, Sustainability
Category(s): Technology Classifications > Chemistry > Polymers, Technology Classifications > Medical > Medical Devices, Technology Classifications > Engineering > Chemical Engineering, Technology Classifications > Advance Materials > A/M Manufacturing
Tumor Tissues Harboring Mutations in cAMP-specific Phosphodiesterases
Abstract: The National Institute of Child Health and Human Development (NICHD), Division of Intramural Research, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize clinical samples with genetic mutations associated with endocrine tumors. Researchers at the...
Published: 4/8/2024   |   Inventor(s): Constantine Stratakis, Anelia Horvath, Kit Man Tsang
Keywords(s): Biomarker, Clinical Samples, Endocrine Tumors, Phosphodiesterase Inhibitors, Research Tools
Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing
New Cancer Research Model: Spontaneously Transformed Mouse Epithelial Cancer Cell Lines
Abstract: The National Cancer Institute Cancer Genetics Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize mouse epithelial cancer cell lines. Investigators at the NIH have created a collection of 45 mouse epithelial cancer cell lines derived from six...
Published: 7/25/2024   |   Inventor(s): Hesed Padilla-Nash, Thomas Ried, Karen Hathcock, Nicole McNeil Ford
Keywords(s): Mouse Epithelial Cancer Cell Lines, Research Tools
Category(s): Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Method to visualize Alu RNA in tissue
Advantages: Spatial localization Compatibility with Fixed Tissues Multiplexing Capabilities Business Summary: Retrotransposons (RTs) are the most abundant class of the transposable elements that comprise approximately 45% of the human genomic sequence, of which Alu repeats (Alus) are the most abundant and comprise 11% of the genomic sequence....
Published: 5/20/2024   |   Inventor(s): Hana Totary-Jain
Keywords(s): Genetics, Medical Devices, Research Tools
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology
Nanoparticle ultrasound contrast agents with high acoustic activity
Summary Contrast-enhanced ultrasound allows for low-cost minimally-invasive imaging; however, the size of typical contrast reagents prevents them from penetrating tumors thereby limiting their utility for cancer diagnostic and therapeutic purposes (theranostics). Oregon Health & Science University (OHSU) researchers have developed novel nanoparticle...
Published: 11/22/2023   |   Inventor(s): Adem Yildirim, Jose Luis Montoya Mira, Sadik Esener, Stuart Ibsen
Keywords(s): Diagnostics, Diagnostics - Cancer, Imaging, Imaging - Acoustic, Research Tools, Therapeutics
Category(s): Diagnostics, Imaging, Nanoscience & Microtechnologies, Research Tools, Therapeutics
Rapid antibody conjugation technique
­Summary The current technology is an improved method of antibody conjugation that allows for rapid and scalable antibody labeling, which could be utilized for a number of omics techniques and other antibody-based platforms. Technology Overview In order to label and functionalize antibodies, direct or secondary conjugations are typically employed....
Published: 11/2/2023   |   Inventor(s): Kai Tao, Srivathsan Ranganathan, Emine (Sila) Ozdemir, Matthew Rames, Michael Brasino, Mingchong Dai, Gulsu Sener Yildrim
Keywords(s): Research Tools
Category(s): Research Tools, Proteomics
De novo peptide sequencer
Summary De novo protein-sequencing approaches are poised to revolutionize nearly all fields of biological research and medicine; however current approaches are low-throughput and limited in their sensitivity. The current technology is a novel method that could be implemented with existing reagents and equipment to improve de novo peptide sequencing...
Published: 7/19/2024   |   Inventor(s): Eugene Tu, Fehmi Civitci, Kevin Schilling, Mingchong Dai, Nicholas Groves, Justin Plaut, Srivathsan Ranganathan, Andy Mendoza, Riccardo Carloni, Yu-Jui (Roger) Chiu, Emine (Sila) Ozdemir, Bruce Branchaud
Keywords(s): Research Tools, Research Tools - Other
Category(s): Proteomics, Research Tools
Improved detection of heart-rate variability for wearable devices
Summary Heart-rate variability (HRV) is a suggested marker of the autonomic nervous system, but artifacts produced by movement with wrist worn devices decreases the validity and utility of this data. Oregon Health & Science University researchers have developed an improved method of removing motion artifacts, understanding the amount of data that...
Published: 3/24/2023   |   Inventor(s): David Sheridan, Steven Baker, Ryan Dehart
Keywords(s): Diagnostics, Research Tools, Software
Category(s): Diagnostics, Research Tools, Software
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