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Search Results - research+tools
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Endothelium-Specific Laminin Reporter Mouse Line Laminin-mCherry/eGFP+/–; Cdh5-CreER+/– Mouse Line
Advantages Enables endothelial-specific labeling of laminin-γ1 in vivo. Tamoxifen-inducible system allows temporal control of recombination. Dual-color fluorescence distinguishes target cell-derived laminin from other cell-derived laminin. Co-localization with laminin-γ1 antibody confirms biological fidelity. Facilitates mapping...
Published: 10/9/2025
|
Inventor(s):
Yao Yao
Keywords(s):
Animal Models
,
Research Tools
Category(s):
Technology Classifications >
Research Tools
/Copyright > Animal Models
Novel Laminin Reporter Mouse Line for in vivo Imaging and Laminin Biology Research (Laminin-mCherry/eGFP+/-) Pre-Cre
Advantages First-ever dual-color laminin reporter mouse line. Enables visualization of laminin-γ1 expression in vivo with high fidelity. mCherry signal replicates endogenous laminin distribution without Cre activation. No background eGFP signal ensures clean baseline imaging. Targets the widely expressed γ1 subunit, enhancing...
Published: 10/9/2025
|
Inventor(s):
Yao Yao
Keywords(s):
Animal Models
,
Neuroscience
,
Research Tools
Category(s):
Technology Classifications >
Research Tools
/Copyright > Animal Models
A Novel Preclinical Model of Neonatal Necrotizing Enterocolitis
Advantages: Uniquely replicates the clinical scenario of RBC transfusion-exacerbated NEC in anemic neonates, providing a more accurate model than the traditional method Provide superior mechanistic insights, offering precise investigation of molecular pathways compared to in vitro intestinal injury assays Cost-effective and high-throughput experimentation,...
Published: 1/17/2025
|
Inventor(s):
Akhil Maheshwari
,
Mohan Krishnan
Keywords(s):
Animal Models
,
Research Tools
Category(s):
Technology Classifications > Medical
Cadaveric 6-Axis Spine Simulator for Assessing Spinal Biomechanics
Advantages: Spine simulator helps assess the biomechanical effects of various interventions to the spine that include surgical implants, excision, or fusion, previously limited by range of motion Interventions for spinal injuries can be tested through highly customizable repeat simulations before and after various injuries / interventions Improved...
Published: 10/22/2024
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Inventor(s):
Nathan Schilaty
Keywords(s):
Medical Devices
,
Research Tools
,
Surgical Tools
Category(s):
Technology Classifications > Medical > Medical Devices
The Sudden Head Acceleration & Kinetic Encephalopathy (SHAKEn™) Device for Preclinical Modeling of Rotational Brain Injury
Advantages: User control to adjust the positioning of the body plate (in the x/y plane) to optimize spinal alignment relative to the axis of rotation prior to insult. An aeronautics-grade angular rate sensor for direct measurement of angular velocity and to calculate rotational acceleration of the head. An electric plug to power accelerations...
Published: 7/18/2024
|
Inventor(s):
Travis Jackson
Keywords(s):
Animal Models
,
Lab Apparatus
,
Laboratory Devices
,
Neuroscience
,
Research Tools
Category(s):
Technology Classifications >
Research Tools
/Copyright > Animal Models
,
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Medical Devices
,
Technology Classifications > Medical > Neuroscience
A microcontroller for easier whole-cell patch clamping on dendrites and axons
Summary The current technology is a microcontroller that allows for the application of controlled negative pressure and simultaneous electrical impulses to make it easier to obtain whole-cell patch clamp recordings on small cellular structures. Technology Overview Whole-cell patch clamping is a technique commonly employed to study the electrical...
Published: 2/27/2025
|
Inventor(s):
Stephen Smith
,
Timur Tsintsadze
Keywords(s):
Research Tools
,
Research Tools
- Other
Category(s):
Research Tools
Surface Functionalization of Polymers Via Sequential Multiple Plasma Gas Treatments
Advantages: Improves hydrophobicity and hydrophilicity, optimizing material performance for diverse applications. Benefits medical implants, self-cleaning surfaces, and more, offering broad utility across industries. Preserves core material characteristics while enhancing surface properties, ensuring stability and reliability. Summary: This...
Published: 10/14/2025
|
Inventor(s):
Nurettin SAHINER
,
Ramesh Ayyala
,
Venkat Bhethanabotla
Keywords(s):
3D Printing
,
Anti-Microbials
,
Biotechnology
,
Catheters
,
CleanTech
,
Construction
,
Dental Equipment
,
Environmental Sciences
,
Food Science
,
Material Science
,
Medical Devices
,
Ocean / Marine Technology
,
Ophthalmic Equipment
,
Research Tools
,
Sustainability
Category(s):
Technology Classifications > Chemistry > Polymers
,
Technology Classifications > Medical > Medical Devices
,
Technology Classifications > Engineering > Chemical Engineering
,
Technology Classifications > Advance Materials > A/M Manufacturing
New Cancer Research Model: Spontaneously Transformed Mouse Epithelial Cancer Cell Lines
Abstract: The National Cancer Institute Cancer Genetics Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize mouse epithelial cancer cell lines. Investigators at the NIH have created a collection of 45 mouse epithelial cancer cell lines derived from six...
Published: 8/19/2025
|
Inventor(s):
Hesed Padilla-Nash
,
Karl Ried
,
Karen Hathcock
,
Nicole McNeil Ford
Keywords(s):
Mouse Epithelial Cancer Cell Lines
,
Research Tools
Category(s):
Application > Research Materials
,
TherapeuticArea > Oncology
,
Collaboration Sought > Licensing
Method to visualize Alu RNA in tissue
Advantages: Spatial localization Compatibility with Fixed Tissues Multiplexing Capabilities Business Summary: Retrotransposons (RTs) are the most abundant class of the transposable elements that comprise approximately 45% of the human genomic sequence, of which Alu repeats (Alus) are the most abundant and comprise 11% of the genomic sequence....
Published: 10/14/2025
|
Inventor(s):
Hana Totary-Jain
Keywords(s):
Genetics
,
Medical Devices
,
Research Tools
Category(s):
Technology Classifications > Medical
,
Technology Classifications > Medical > Medical Diagnostics
,
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical > Biotechnology
Nanoparticle ultrasound contrast agents with high acoustic activity
Summary Contrast-enhanced ultrasound allows for low-cost minimally-invasive imaging; however, the size of typical contrast reagents prevents them from penetrating tumors thereby limiting their utility for cancer diagnostic and therapeutic purposes (theranostics). Oregon Health & Science University (OHSU) researchers have developed novel nanoparticle...
Published: 11/22/2023
|
Inventor(s):
Adem Yildirim
,
Jose Luis Montoya Mira
,
Sadik Esener
,
Stuart Ibsen
Keywords(s):
Diagnostics
,
Diagnostics - Cancer
,
Imaging
,
Imaging - Acoustic
,
Research Tools
,
Therapeutics
Category(s):
Diagnostics
,
Imaging
,
Nanoscience & Microtechnologies
,
Research Tools
,
Therapeutics
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