Search Results - metabolic+disease+treatments

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HDAC Inhibitors for Managing Vascular Conditions and Diabetic Peripheral Neuropathies
Application Treatment of diabetic neuropathy using epigenetic modulators, histone deacetylase inhibitors (HDACis), to ameliorate or prevent vascular conditions and neuropathic pains by nerve damages. Key Benefits Reverses or protects against diabetes-induced nerve damages by direct injection of HDACi. Relatively low regulatory risk because many...
Published: 7/22/2025   |   Inventor(s): Young-Sup Yoon, Ji Woong (Jay) Han, Hyunsuk Shim
Keywords(s): Cell Therapy, Metabolic Disease Treatments, Neurology and Pain Treatments, Repurposed Drug, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Novel Inhibitors of NOX2/ROS
Applications Novel therapeutics for treatment of various inflammatory airway conditions including chronic obstructive pulmonary disease (COPD). Key Benefits NOX2/ROS inhibitors have potential for use in a wide variety of clinical indications. Current treatments are weakly effective or provide only symptomatic relief for inflammatory airway diseases. Technical...
Published: 2/13/2025   |   Inventor(s): Thota Ganesh, John David Lambeth, Susan Smith, Aiming Sun
Keywords(s): Cardiovascular Treatments, Immunology and Inflammation Treatments, Metabolic Disease Treatments, Neurology and Pain Treatments, Respiratory Treatments, Small Molecule
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
Functional Restoration of Diabetic Bone Marrow-Derived Cells
Application Methods for restoration of diabetic bone marrow cell function for cell based therapy, using pre-existing molecules and their derivatives. Key Benefits Ability to "reactivate" diabetic bone marrow-derived stem or progenitor cells which also include peripheral blood cells such as endothelial progenitor cells. Cells are more...
Published: 5/30/2025   |   Inventor(s): Young-Sup Yoon, Ji Woong (Jay) Han
Keywords(s): Cell Therapy, Metabolic Disease Treatments, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Neurotrophic Factor as Therapeutic for Diabetes
Application The use of Glial Cell-derived Neurotrophic Factor (GDNF) or its mimics as a potential therapeutic for diabetes mellitus type 1 (IDDM). Key Benefits GDNF enhances pancreatic β-cell growth and survival in vitro and in vivo. GDNF transgenic mice have lower blood glucose levels and are more resistant to developing diabetes compared...
Published: 7/22/2025   |   Inventor(s): Shanthi Srinivasan
Keywords(s): Metabolic Disease Treatments
Category(s): TechPub Algolia > Therapeutics