Search Results - metabolic+disease+treatments

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Novel Endoglycosidase Derivatives Treating Diseases of the Adaptive Immune System
Application Protein-based therapeutics for the treatment of IgG-mediated diseases. Key Benefits A new class of endoglycosidases for the treatment of IgG-mediated diseases. Four novel compounds have been developed that exhibited robust in vitro activity. Potential to become first-in-class medications for dysregulation of the adaptive immune system,...
Published: 2/13/2025   |   Inventor(s): Eric Sundberg, Diego Sastre, Jonathan Du, Jeffrey Ravetch, Stylianos Bournazos
Keywords(s): Enzyme and Protein Research, Immunology and Inflammation Treatments, Metabolic Disease Treatments, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics
HDAC Inhibitors for Managing Vascular Conditions and Diabetic Peripheral Neuropathies
Application Treatment of diabetic neuropathy using epigenetic modulators, histone deacetylase inhibitors (HDACis), to ameliorate or prevent vascular conditions and neuropathic pains by nerve damages. Key Benefits Reverses or protects against diabetes-induced nerve damages by direct injection of HDACi. Relatively low regulatory risk because many...
Published: 2/13/2025   |   Inventor(s): Young-Sup Yoon, Ji Woong (Jay) Han, Hyunsuk Shim
Keywords(s): Cell Therapy, Metabolic Disease Treatments, Neurology and Pain Treatments, Repurposed Drug, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Novel Inhibitors of NOX2/ROS
Applications Novel therapeutics for treatment of various inflammatory airway conditions including chronic obstructive pulmonary disease (COPD). Key Benefits NOX2/ROS inhibitors have potential for use in a wide variety of clinical indications. Current treatments are weakly effective or provide only symptomatic relief for inflammatory airway diseases. Technical...
Published: 2/13/2025   |   Inventor(s): Thota Ganesh, John David Lambeth, Susan Smith, Aiming Sun
Keywords(s): Cardiovascular Treatments, Immunology and Inflammation Treatments, Metabolic Disease Treatments, Neurology and Pain Treatments, Respiratory Treatments, Small Molecule
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
Functional Restoration of Diabetic Bone Marrow-Derived Cells
Application Methods for restoration of diabetic bone marrow cell function for cell based therapy, using pre-existing molecules and their derivatives. Key Benefits Ability to "reactivate" diabetic bone marrow-derived stem or progenitor cells which also include peripheral blood cells such as endothelial progenitor cells. Cells are more...
Published: 2/13/2025   |   Inventor(s): Young-Sup Yoon, Ji Woong (Jay) Han
Keywords(s): Cell Therapy, Metabolic Disease Treatments, Small Molecule
Category(s): TechPub Algolia > Therapeutics