Search Results - enzyme+and+protein+research

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Functionalized Collagen Biochips with Core-Shell Structures and Collagen-Mimetic Peptide Nanotubes
Application Synthetic collagen-based biomaterials for therapeutic delivery or drug testing. Key Benefits Synthetic collagen substitute. Capable of formulating into various structures. Free of animal-based contaminants. Able to be spatially patterned. Market Summary Organ failure and tissue defects affect millions of Americans, resulting in...
Published: 3/28/2025   |   Inventor(s): Vincent Conticello, Andrea Merg, Gavin Touponse
Keywords(s): Biomaterials, Enzyme and Protein Research
Category(s): TechPub Algolia > Micro and Nanotechnology
KRAS Mutant Protein-Protein Interaction Targets and Inhibitors for Cancer Therapy
Application Immunotherapeutic agent and biosensor for KRASG12V mutation in tumor cells. Key Benefits First in class, targeted immunotherapy for patients presented with KRASG12V mutation. Attenuates immune suppression associated with KRASG12V-positive cancers. Market Summary The KRASG12V mutation, representing 85% of all cancer mutations, is...
Published: 3/28/2025   |   Inventor(s): Haian Fu, Cong Tang, Xiulei Mo
Keywords(s): Drug Target Identification, Enzyme and Protein Research, Immunology and Inflammation Treatments, Oncology Treatments
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
Caspase-3 Deficient MEFs with Mutant Caspase-3 Re-Introduced
Application Mouse embryonic fibroblast (MEF) line deficient in caspase-3 that are reconstituted with constitutively expressed mutant versions of the protease. Key Benefits An immortalized caspase-3-deficient MEF cell line. Tool to study protease induced apoptosis. Technical Summary Emory inventors have discriminated a previously unknown role...
Published: 2/13/2025   |   Inventor(s): Lawrence Boise, Katelyn Ponder
Keywords(s): Cell Lines and Organoids, Enzyme and Protein Research
Category(s): TechPub Algolia > Research Tools
Photocaged Cytokines for Cancer Immunotherapy
Application Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy. Key Benefits Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity. Prolonged circulation means less frequent dosing is required. Biased activity towards CD8+ T-cells...
Published: 3/28/2025   |   Inventor(s): Erik Dreaden, Lacey Perdue, Priscilla Do
Keywords(s): Biologics, Enzyme and Protein Research, Immunology and Inflammation Treatments, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics
Ribosome Pegging: An Antibiotic-free System to Produce Recombinant Proteins
Application Antibiotic-free method to prevent the growth of cells that fail to express high levels of a non-essential protein (target protein). Key Benefits Prevents the use of antibiotics and markers that promote resistance. Facilitates the deployment of recombinant bacteria in uncontrolled environments. Stabilizes heterologous expression of...
Published: 2/13/2025   |   Inventor(s): Ichiro Matsumura
Keywords(s): Enzyme and Protein Research, Platform, Production Methods
Category(s): TechPub Algolia > Research Tools
Selective Enrichment of A-To-I Edited Transcripts from Cellular RNA Using Endonuclease V
Application Kit to efficiently identify and enrich adenosine-to-inosine (A-to-I) editing in RNA molecules. Key Benefits Robust and facile method for enriching A-to-I edited transcripts. Overcomes the low efficiency and accuracy of transcriptome-wide RNA-seq. Market Summary A-to-I RNA editing by adenosine deaminases is a common RNA modification...
Published: 2/13/2025   |   Inventor(s): Steven Knutson, Jennifer Heemstra
Keywords(s): Enzyme and Protein Research
Category(s): TechPub Algolia > Research Tools
DNAzyme Nanoparticles for the Cleavage of RNA
Application Site-selective RNA splicing nanozyme for cleaving and ligating RNA. Key Benefits Can cleave virtually any RNA stem loop. Removes a 19 nucleotide segment from a 67 nucleotide RNA loop with up to 66% efficiency. Technical Summary Modulating RNA can be useful for studying RNA biology, gene knockdown, and regulating RNA splicing. Scientists...
Published: 3/6/2025   |   Inventor(s): Jessica Petree, Kevin Yehl, Khalid Salaita
Keywords(s): Enzyme and Protein Research, Gene Therapy and Editing
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Micro and Nanotechnology
Trimeric Immunogen for HIV-1 Vaccination
Application Trimeric gp120 immunogen that induces broadly cross-reactive V1V2-antibodies for HIV-1 vaccine. Key Benefits Possible oral administration. Broadly cross-reactive against HIV-1 panel. Promotes antibody responses as both a primary immunogen and boosting immunogen. Market Summary Antiretroviral therapy (ART) has dramatically prolonged...
Published: 2/28/2025   |   Inventor(s): Rama Rao Amara, Andrew Jones, Raghavan Varadarajan, Sannula Kesavardhana
Keywords(s): Antibodies, Enzyme and Protein Research, Microbiology and Infectious Disease Treatments, Preventive Vaccines
Category(s): TechPub Algolia > Vaccines
IFN Gamma Prelicensing for Improved Mesenchymal Stromal Cell Function Post-Thaw
Application Mesenchymal stromal cells (MSC) prelicensed with pro-inflammatory cytokines for improved survival and immunosuppressive properties following cryopreservation. Key Benefits Preserves the immunosuppressive function of MSCs following thawing. Improves effectiveness of transplanted MSCs following cryopreservation. Market Summary Mesenchymal...
Published: 2/13/2025   |   Inventor(s): Jacques Galipeau, Raghavan Chinnadurai
Keywords(s): Biologics, Cell Therapy, Enzyme and Protein Research, Immunology and Inflammation Treatments
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Research Tools
GeneRegs: Nanoparticles for Treatment of Severe Asthma
Application Gold nanoparticles coated with enzyme which specifically targets and degrades asthma-associated inflammation molecules. Key Benefits Specifically suppresses asthma associated inflammation. Easy self-administration by inhalation. Market Summary Asthma is defined as a chronic inflammatory lung disease with significant worldwide morbidity....
Published: 2/28/2025   |   Inventor(s): Khalid Salaita, Cherry Wongtrakool, Kornelia Galior
Keywords(s): COVID19, Enzyme and Protein Research, Immunology and Inflammation Treatments, Nanoparticle Drug Delivery, Respiratory Treatments
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Micro and Nanotechnology
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