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Search Results - zhiqiang+yu
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S100A4 Monoclonal Antibody for Therapeutic and Diagnostic Use
Cancer metastasis are responsible for ~90% of cancer associated deaths. Recent studies suggest that immune cells play critical roles in promoting metastasis, especially myeloid cells from the bone marrow. UTHealth researchers, with researchers from The Methodist Hospital, observed a highly conserved expression of S100A4 in immune suppressive myeloid...
Published: 10/21/2024
|
Inventor(s):
Zhiqiang An
,
Ningyan Zhang
Keywords(s):
Category(s):
Neurology/Neurosurgery
,
Oncology
,
Therapeutics
LILRB2 Monoclonal Antibody for Therapeutic and Diagnostic Uses of Neurodegenerative Diseases
Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. TREM2 signaling inhibition is mediated by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2). UTHealth inventors created and engineered...
Published: 10/21/2024
|
Inventor(s):
Zhiqiang An
,
Ningyan Zhang
Keywords(s):
Category(s):
Neurology/Neurosurgery
,
Therapeutics
Portable Railroad Grade Crossing Monitoring System
Reference #: 1676 The University of South Carolina is offering licensing opportunities for Portable Railroad Grade Crossing Monitoring System. Background: Every year, a significant number of accidents occur at railroad crossings, involving collisions between trains and pedestrians, vehicles, or other obstacles. Whether due to intentional actions...
Published: 9/26/2024
|
Inventor(s):
Yu Qian
Keywords(s):
Category(s):
Advanced Materials
,
Engineering and Physical Sciences
Antibodies against CD5L for therapeutic and diagnostic uses
Provided herein are anti-CD5L monoclonal antibodies. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer. UTHealth Ref. No.: 2020-0016 Inventors: Dr. Zhiqiang An and Dr. Ningyan Zhang at UTHealth; Dr. Anil Sood at UT M.D. Anderson Cancer Center Patent Status: PCT application PCT/US2021/025429...
Published: 10/21/2024
|
Inventor(s):
Zhiqiang An
,
Ningyan Zhang
,
Anil Sood
Keywords(s):
Category(s):
Biologics
,
Oncology
,
Therapeutics
Portable Railroad Track Component Inspection System
Reference #: 01660 The University of South Carolina is offering licensing opportunities for Potable Railroad Track Component Inspection System Background: The Federal Railroad Administration (FRA) stipulates routine track inspections to maintain railroad safety and efficiency. However, conventional manual inspections are not only inefficient and...
Published: 1/6/2025
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Inventor(s):
Yu Qian
,
Yi Wang
Keywords(s):
Category(s):
Software and Computing
Monoclonal Antibodies Against PCDH7 for Therapeutic and Diagnostic Use
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths worldwide. UTHealth researchers discovered that the cell surface protein Protocadherin 7 (PCDH7) is highly expressed in NSCLC and promotes lung cancer development. Inventors at UTH in collaboration with Dr. O’Donnell’s group at UTSW have discovered a panel...
Published: 10/21/2024
|
Inventor(s):
Zhiqiang An
,
Ningyan Zhang
,
Kathryn O'Donnell
Keywords(s):
Category(s):
Diagnostics
,
Oncology
,
Therapeutics
,
Biologics
Monoclonal antibodies against human endotrophin for therapeutic and diagnostic use.
Background Studies have shown that endotrophin, the carboxy-terminal cleavage product of the COL6α3 chain, has potent effects on transformed mammary ductal epithelial cells in rodents. It is abundantly expressed in adipose tissue and is a chemoattractant for macrophages, exerts effects on endothelial cells and enhances the progression through...
Published: 10/21/2024
|
Inventor(s):
Zhiqiang An
,
Ningyan Zhang
,
Philipp Scherer
Keywords(s):
Category(s):
Biologics
,
Oncology
,
Therapeutics
Monoclonal Antibodies Binding to Transferrin Receptor (TfR) for Therapeutic Protein Delivery across Blood-Brain Barrier
Blood-brain barrier (BBB) limits brain entry and is one of the major hurdles in developing antibody and protein-based therapeutics for central nervous system (CNS) diseases. UTHealth researchers identified and engineered monoclonal antibodies binding to transferrin receptor (TfR) but not affecting transferrin (Tf) binding to TfR. An engineered monovalent...
Published: 10/21/2024
|
Inventor(s):
Zhiqiang An
Keywords(s):
Category(s):
Drug Delivery
,
Therapeutics
,
Neurology/Neurosurgery
,
Oncology
,
Biologics
TREM2 Monoclonal Antibody for Therapeutic and Diagnostic Use
Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. Previous studies in rodent models of AD have shown that mice with increased TREM2 expression have reduced amyloid pathology. UTHealth inventors created and...
Published: 10/21/2024
|
Inventor(s):
Zhiqiang An
Keywords(s):
Category(s):
Therapeutics
,
Diagnostics
,
Biologics
,
Neurology/Neurosurgery
Facial Recognition Based on Converted Spiking Neural Network
Reference #: 01602 The University of South Carolina is offering licensing opportunities for Facial Recognition Based on Converted Spiking Neural Network Background: The current method for facial recognition requires a lot of computing resources (high-performance computers) which is not portable, and the accuracy is very limited. Invention Description: We...
Published: 10/17/2024
|
Inventor(s):
Yu Qian
,
Youzhi Tang
Keywords(s):
deep learning
,
Facial recognition
,
mobile computing
,
Spiking neural networks
Category(s):
Software and Computing
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