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Search Results - ivet+bahar
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Small Molecule Inhibitors Targeting OTUD4-CD73 Interaction for Immune-Cold Tumors
Application This technology introduces small molecule inhibitors, ST80 and Z22, to disrupt the protein-protein interaction (PPI) between OTUD4 and CD73. These inhibitors enhance tumor immunogenicity by reducing CD73 stabilization, improving the immune response in triple-negative breast cancer (TNBC) and other immune-cold tumors. Key Benefits ST80...
Published: 11/13/2025
|
Inventor(s):
Yong Wan
,
Yueming Zhu
,
Ivet Bahar
,
Anupam Banerjee
,
Jiyoung Lee
Keywords(s):
Drug Target Identification
,
Immunotherapy
,
Oncology Treatments
,
Small Molecule
,
Therapeutics
Category(s):
TechPub Algolia > Drug Discovery