Search Results - adeno-associated+virus

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HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS

HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS Researchers at UCSF and UC Berkeley have developed a recombinant adeno-associated virus (rAAV) with an altered capsid protein, where the rAAV exhibits greater ability to infect a central nervous system cell compared to wild-type AAVs. The central nervous system (CNS) comprises a multitude...

Published: 10/26/2023 | Inventor(s): Tomasz Nowakowski, Galina Popava (Schmunk), David Schaffer, Danqing Zhu

Keywords(s): Adeno-associated Virus, Brain, Neuron

Category(s): Technology Classifications > Biology

Gene Therapy for Treatment of CRX-Autosomal Dominant Retinopathies

Abstract: Mutations in the cone rod homeobox (CRX) transcription factor lead to distinct retinopathy phenotypes, including early-onset vision impairment in dominant Leber congenital amaurosis (LCA). Adeno-Associated virus (AAV) vector-mediated delivery of a CRX cDNA under the control of a CRX promoter region partially restored photoreceptor phenotype...

Published: 4/8/2024 | Inventor(s): Anand Swaroop, Kamil Kruczek, Suja Hiriyanna, Zhijian Wu

Keywords(s): AAV, Adeno-associated Virus, Cone-rod Dystrophy, CRD, GENE THERAPY, LCA, Leber Congenital Amaurosis, Lentivirus, NEI, rare disease, Retinitis Pigmentosa, Retinopathies, RP, Swaroop

Category(s): TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration

AAV Mediated CTLA-4 Gene Transfer to Treat Sjogren's Syndrome

Sjögren’s syndrome is an autoimmune disease that affects over 2 million Americans, primarily over the age of 40. One of the major outcomes of Sjögren's syndrome is xerostomia (dry mouth) that is caused by immune system attack on moisture producing salivary glands. Researchers at the National Institute of Dental and Craniofacial Research have developed...

Published: 7/25/2024 | Inventor(s): John (Jay) Chiorini, Hongen Yin

Keywords(s): Adeno-associated, Adeno-associated Virus, IB3XXX, IBXXXX, IXXXXX, Sjogren's, Sjogren's syndrome, Syndrome, T-LYMPHOCYTE, virus, Xerostomia

Category(s): Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Immunology

rAAV Vector Gene Therapy for Medullary Thyroid Carcinoma

Targets Cancerous Cells and Uses Tissue-Specific Promoters to Promote Gene ExpressionThis gene therapy utilizes rAAV vectors to target metastatic medullary thyroid carcinoma cells, providing a treatment for the highly aggressive form of thyroid cancer. With available treatments, medullary thyroid carcinoma is incurable once metastasized; for example,...

Published: 6/27/2021 | Inventor(s): Arun Srivastava, Jacqueline Hobbs, Scott Rivkees, Laura Adamson

Keywords(s): Adeno-Associated Virus, calcitonin, Gene Therapy, medullary thyroid carcinoma

Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Therapeutics