Search Results - adeno-associated+virus

3 Results

Sort By:

HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS

HUMAN CENTRAL NERVOUS SYSTEM (CNS) TARGETING AAV VARIANTS Researchers at UCSF and UC Berkeley have developed a recombinant adeno-associated virus (rAAV) with an altered capsid protein, where the rAAV exhibits greater ability to infect a central nervous system cell compared to wild-type AAVs. The central nervous system (CNS) comprises a multitude...

Published: 10/26/2023 | Inventor(s): Tomasz Nowakowski, Galina Popava (Schmunk), David Schaffer, Danqing Zhu

Keywords(s): Adeno-associated Virus, Brain, Neuron

Category(s): Technology Classifications > Biology

Gene Therapy for Treatment of CRX-Autosomal Dominant Retinopathies

Abstract: Mutations in the cone rod homeobox (CRX) transcription factor lead to distinct retinopathy phenotypes, including early-onset vision impairment in dominant Leber congenital amaurosis (LCA). Adeno-Associated virus (AAV) vector-mediated delivery of a CRX cDNA under the control of a CRX promoter region partially restored photoreceptor phenotype...

Published: 12/6/2024 | Inventor(s): Anand Swaroop, Kamil Kruczek, Suja Hiriyanna, Zhijian Wu

Keywords(s): AAV, Adeno-associated Virus, Cone-rod Dystrophy, CRD, GENE THERAPY, LCA, Leber Congenital Amaurosis, Lentivirus, NEI, rare disease, Retinitis Pigmentosa, Retinopathies, RP, Swaroop

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology

rAAV Vector Gene Therapy for Medullary Thyroid Carcinoma

Targets Cancerous Cells and Uses Tissue-Specific Promoters to Promote Gene ExpressionThis gene therapy utilizes rAAV vectors to target metastatic medullary thyroid carcinoma cells, providing a treatment for the highly aggressive form of thyroid cancer. With available treatments, medullary thyroid carcinoma is incurable once metastasized; for example,...

Published: 6/27/2021 | Inventor(s): Arun Srivastava, Jacqueline Hobbs, Scott Rivkees, Laura Adamson

Keywords(s): Adeno-Associated Virus, calcitonin, Gene Therapy, medullary thyroid carcinoma

Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Therapeutics