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16950
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ID
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Quinoline-
d
erived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lea
d
compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Prakash Ja
d
hav
,
Bin Tan
,
Haozhou Tan
Keywords(s):
Antiviral
Category(s):
Technology Classifications > COVI
D
-19
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious
D
isease
,
Technology Classifications > Therapeutics
Specific inhibitors to mitigate mu opioi
d
‐induced side‐effects without compromising analgesia
Preliminary
d
ata shows that the inhibitor significantly mitigates morphine tolerance in a mouse study Invention Summary: Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine,...
Published: 7/31/2025
|
Inventor(s):
Yingxian Pan
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications
,
Technology Classifications > Therapeutics
Metho
d
for Optimizing an Integrated Flight Control System using Reinforcement Meta-Learning
This technology is a metho
d
to incorporate reinforcement meta-learning to the design of a flight control system for missiles. The integration will benefit the control system, as it optimizes it with the help of a simulation environment. The technology removes the need for manual tuning of the control system settings. Background: The flight control...
Published: 7/30/2025
|
Inventor(s):
Roberto Furfaro
,
Brian Gau
d
et
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology
,
Technology Classifications > Engineering & Physical Sciences > Aerospace Engineering
TRP: A Mouse Mo
d
el of Limb Girdle Muscular Dystrophy Type 2A (R1/D4) (UCLA Case No. 2021-171)
UCLA researchers in the
D
epartment of Neurology have developed a novel mouse model for limb girdle muscular dystrophy, a disorder that causes muscle weakness in the limbs and hip area. BACKGROUND: Limb-Girdle Muscular Dystrophy Type 2A (LGMDR1) is a genetic neuromuscular disorder characterized by progressive muscle weakness, primarily affecting muscles...
Published: 7/30/2025
|
Inventor(s):
Melissa Spencer
Keywords(s):
Category(s):
Life Science Research Tools > Animal Mo
d
els
Regioselective 1,2-
D
earomatization of Functionalized Azines by Organolanthanide Catalysts
NU2014-129 INVENTORS Tobin Marks* Alexan
d
er Dudnik Massimiliano Delferro Victoria Weidner SHORT DESCRIPTION This invention describes a catalytic process for the regioselective 1,2-dearomatization of functionalized azines using an organolanthanide catalyst and pinacolborane (HBpin). It offers a streamlined approach to key intermediates for pharmaceuticals...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
Catalyst
,
Chemicals
,
Manufacturing/Processing
,
Materials
Category(s):
Physical Sciences > Materials an
d
Industrial Processes
Novel self-healing commo
d
ity copolymers based on 2-ethylhexyl acrylate
NU2023-240 INVENTORS John Torkelson* Tong Wang SHORT
D
ESCRIPTION This invention describes a new class of random copolymers that exhibit autonomous self-healing behavior at room temperature. The copolymers, derived entirely from commodity comonomers including 2-ethylhexyl acrylate, fully recover their material properties after damage. BACKGROUND The...
Published: 7/30/2025
|
Inventor(s):
Keywords(s):
Materials
,
Polymer
,
Smart/Functional materials
Category(s):
Physical Sciences > Materials an
d
Industrial Processes
Multi-Particle System for Capture an
d
Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: UCLA researchers in the
D
epartment of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 7/29/2025
|
Inventor(s):
D
ino Di Carlo
,
Alyssa Arnheim
,
Michael Mello
d
y
,
Yuta Nakagawa
,
Lily Shang
Keywords(s):
Assay
,
B Cell
,
barco
d
e
,
Bioassay
,
biological assays
,
Biomarker
,
biomarkers
,
Biomaterial
,
capping particles
,
CAR-T cell platform
,
CAR-T cell therapy
,
cavities
,
cavity-containing particles
,
Cell an
d
tissue culture
,
cell encapsulation
,
cell engineering
,
cell imaging
,
cell mapping
,
cell sorting
,
cell type i
d
entification
,
cell-base
d
therapy
,
centrifugation
,
confinement
,
D
iagnostic Platform Technologies (E.G. Microfluidics)
,
D
igital Microfluidics
,
D
rug
,
D
rug Delivery
,
D
rug Discovery
,
d
rug screening
,
high throughput
,
high throughput assays
,
high throughput testing
,
high-throughput analysis
,
High-Throughput Screening
,
Immunoassay
,
Immunoassay Sense (Molecular Biology)
,
Microflui
d
ics
,
Microflui
d
ics And Mem's
,
Microflui
d
ics Nanosphere
,
microparticles
,
moieties
,
Nanoparticle
,
single cell analysis
,
single cell analysis an
d
testing
,
Single cell
d
ata
,
single-cell resolution
,
single-cell trapping
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Cell Counting An
d
Imaging
,
Life Science Research Tools > Lab Equipment
,
Life Science Research Tools > Microscopy An
d
Imaging
,
Life Science Research Tools > Microflui
d
ics And Mems
,
Me
d
ical Devices
,
Platforms
Covalent A
d
aptable Networks with Associative Siloxane Exchange Enabled by Amide-Based Internal Catalysis
NU2025-056 INVENTORS John Torkelson* Tapas
D
ebsharma Nathan Purwanto Tong Wang SHORT DESCRIPTION A technology that introduces internally catalyzed siloxane dynamic chemistry in covalent adaptable networks (CANs) through amide-based catalysis to produce recyclable and reprocessable polymers with maintained cross-link density at elevated temperatures. BACKGROUND Replacing...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Physical Sciences > Materials an
d
Industrial Processes
Recyclable an
d
Depolymerizable Polymer Network Materials via Thiourethane Dynamic Chemistry
NU2019-126 INVENTORS John Torkelson* Lingqiao Li Xi Chen SHORT
D
ESCRIPTION A class of reprocessable, PU-like polymer networks synthesized via thiourethane dynamic chemistry that allow for complete cross-link density recovery and offer the potential for monomer recovery under mild conditions. BACKGROUND Traditional cross-linked polyurethane...
Published: 7/29/2025
|
Inventor(s):
Keywords(s):
Category(s):
Physical Sciences > Materials an
d
Industrial Processes
Fusion Protein for
D
evelopment of Transgenic Resistance to Lepidopteran Pests
A Specific, Eco-Frien
d
ly Approach to Pest Control Using Genetically Engineered Biopesticides A fusion protein comprised of a densovirus coat protein, a proline-rich linker, and an insect-specific neurotoxin allows for the development of transgenic crops with resistance to lepidopteran (caterpillar) pests. Insects cause agricultural loss and economic...
Published: 7/31/2025
|
Inventor(s):
Bryony Bonning
Keywords(s):
Category(s):
Technology Classifications > Agricultural > Insect Control
,
Technology Classifications > Agricultural > Therapeutics
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