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Methods To Generate Constrained Fluorinated Macrocycles (UCLA Case No. 2023-139)
UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel method to generate fluorinated polycycles, which may be used for downstream drug discovery and development. BACKGROUND: A significant amount of research in the field of organic chemistry centers around generating increasingly complex molecules that cyclize, forming...
Published: 5/30/2025   |   Inventor(s): Patrick Harran
Keywords(s): Drug Discovery
Category(s): Chemical > Synthesis, Chemical > Catalysts
Modified Hyaluronic Acid Hydrogels Containing Hyaluronidase for the Time‐Controlled and Targeted Release of anti-CTLA-4 and other Therapeutic Antibodies (UCLA Case No. 2016-526)
UCLA researchers from the Department of Medicine have developed a novel therapeutic platform for the administration of low-dose Cytotoxic T-lymphocyte Associated Protein 4 (CTLA-4) antibody for cancer immunotherapy that synergizes with conventional PD-1 therapy while sparing systemic autoimmune toxicity. BACKGROUND: Immune checkpoint inhibitor (CPI)...
Published: 5/30/2025   |   Inventor(s): Michael Roth, Airi Harui
Keywords(s): Cancer Immunotherapy, Immunotherapy
Category(s): Platforms > Drug Delivery, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology
A design to manufacture polyamide reverse osmosis membrane using molecular layer-by-layer deposition
Thin-film composite polyamide membranes, are the basis for modern commercial reverse osmosis (RO) membranes. These membranes are created through interfacial polymerization (IP) involving a trifunctional acid chloride (e.g., trimesoyl chloride, TMC, dissolved in an organic solvent) and a difunctional amine (e.g., m-phenylenediamine, MPD, dissolved in...
Published: 5/30/2025   |   Inventor(s): Samarpan Deb Majumder, Xitong Liu
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment, Technology Classifications > Industrial or Consumer Tech > Industrial Manufacturing
Robot-Aided System And Method For Diagnosis Of Autism Spectrum Disorder
Sensory abnormalities are reported to be central to autistic experience. The symptoms include hyposensitivity, hypersensitivity, multichannel receptivity, processing difficulties and sensory overload. Given the intensive and cumbersome nature of current methods of diagnosis, there is a need of behavior-based approach to identify the children at risk...
Published: 5/30/2025   |   Inventor(s): Chung Hyuk Park, Hifza Javed
Keywords(s):  
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Devices > Therapeutic Devices
Tampa Neuromapping Depth Electrode
Advantages Combines recording and stimulation in a single device Reduces brain penetration and surgery time Lowers risk of hemorrhage, infection, and brain shift Enables precise brain mapping and real-time stimulation Summary Deep Brain Stimulation (DBS) helps patients with movement disorders like Parkinson’s disease by sending electrical...
Published: 5/30/2025   |   Inventor(s): Oliver Flouty, Yarema Bezchlibnyk, Vishal Bharmauria, Nour Shaheen, Brian Dalm, Can Sarica, Matthew Howard, Hiroto Kawasaki, Mario Zanaty, Alex Green, Andres Lozano
Keywords(s):  
Category(s): Technology Classifications > Medical > Neuroscience
Engineering Asymmetrically Glycosylated IgG Antibodies
Application A novel method to develop asymmetrically glycosylated therapeutic monoclonal IgG antibodies for preventing and treating diseases like cancer, infectious diseases, and autoimmune disorders. Key Benefits Different IgG antibody glycoforms can be produced, each with its unique effector functions and biological and therapeutic effects. Potential...
Published: 5/30/2025   |   Inventor(s): Eric J. Sundberg, Jonathan Du, Tala Azzam
Keywords(s): Antibodies, Immunology and Inflammation Treatments, Microbiology and Infectious Disease Treatments, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics
Companion Diagnostic for Immunomodulatory Repair Treatments
This technology is a diagnostic tool designed to help match patients to specific drugs or therapies to treat chronic ischemic heart failure. The platform focuses on immune cells called macrophages, which play a crucial role in the body's response to injury and disease. By promoting a specific type of macrophage known to aid healing, this system...
Published: 5/30/2025   |   Inventor(s): Steven Goldman, Daniel Benson, Adrian Grijalva, Jordan Fink, Jordan Lancaster, Jennifer Koevary, Simar Singh
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Healthcare Portfolios > Heart and Vascular
RNA Binding Motif 3 (RBM3) Overexpressing Transgenic Mouse
Advantages • RBM3 upregulation reverses multiple tau phosphorylations post-TBI • Novel RBM3 Overexpressing Transgenic Mouse Model allows researchers to study the effects of RBM3 activation on tissue function, brain function, and brain injury Summary Traumatic brain injury (TBI) not only causes immediate neuronal damage but also...
Published: 5/30/2025   |   Inventor(s): Travis Jackson
Keywords(s): Animal Models, Neuroscience
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology
Method for Co-Localizing Two Proteins on the Inside of the Cell Membrane in Yeast
Advantages Localization of protein interactions at the cell membrane offers a more physiologically relevant model Improved screening by minimizing off-target interactions Broadly applicable and accessible tools Summary Protein-protein interactions involving membrane proteins are notoriously difficult to study under physiologically relevant conditions....
Published: 5/30/2025   |   Inventor(s): Lawrence Stern, Michael Nelson
Keywords(s): Drug Discovery
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Biomaterials
Transgenic Foxc2-tdTomato Overexpressing Mouse Model for Study and Screening of Lymphatic Valve Development
Advantages Tissue specific Foxc2 expression with integrated tdTomato fluorescent reporter enables precise spatiotemporal visualization Enables monitoring of lymphatic valve development 1:1 co-expression of Foxc2 and tdTomato, overcoming expression variability characteristic associated with of IRES-based or viral delivery systems Single-vector...
Published: 5/30/2025   |   Inventor(s): Joshua Scallan
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models
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