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Sulfonyl-triazole activators for cell-selective glycolysis enhancement in cancer and Parkinson’s disease
Background Cellular metabolism is a central regulator of immune cell function and neuronal survival, making it a promising therapeutic target in both cancer and neuro­degenerative disease. In solid tumors, tumor-infiltrating lymphocytes (TILs) frequently succumb to metabolic exhaustion due to the nutrient-depleted and immunosuppressive microenvironment,...
Published: 1/27/2026   |   Inventor(s): Ku-Lung Hsu, Xiaoding Jiang, Xiaolu Cambronne
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug discovery
Microneedle array coating technology for enhanced stability and targeted delivery of mRNA and biologics
A microneedle-based system uses cryogenically pre-cooled needles coated via thin-film freeze-coating to preserve mRNA stability, enabling efficient, multi-therapeutic intradermal delivery of temperature-sensitive drugs. Background The field of advanced drug delivery systems has grown substantially as the biomedical industry grapples with the complexities...
Published: 1/27/2026   |   Inventor(s): Zhengrong Cui, Michael Sandoval, Robert Williams, Drew Weissman, Qin Li
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug discovery
A microneedle-based resonant sensor system for continuous, wireless monitoring of wound and physiological states
This technology uses gold-coated microneedles and wireless sensors to directly sample wound fluid, detecting infection and other changes in real time. Data is analyzed with machine learning and sent to clinicians for early, continuous wound monitoring. Background Wound monitoring is a critical aspect of healthcare, especially for patients recovering...
Published: 1/27/2026   |   Inventor(s): James Clarke, Miles Massidda, Joseph Schmidt, Cristina Checka, Scott Alpard
Keywords(s):  
Category(s): Life sciences > Medical technology > Medical devices
Misalignment Resilient Diffractive Optical Networks (Case No. 2020-885)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed and experimentally validated a comprehensive training scheme that greatly enhances the robustness of diffractive networks to 3D misalignments and fabrication tolerances in their physical implementation. Background: As an optical machine learning framework,...
Published: 1/27/2026   |   Inventor(s): Aydogan Ozcan
Keywords(s): Optical Communication , Optical computing, optical implementation, Optical networks, optical processor
Category(s): Software & Algorithms, Software & Algorithms > Image Processing, Optics & Photonics
Antibody compositions for improving detection and treatment of Bacillus anthracis infections
This technology uses specially designed antibodies with enhanced ability to detect or treat Bacillus anthracis infections, improving both diagnosis and therapy for anthrax. Background Bacillus anthracis, the causative agent of anthrax, is a highly virulent bacterium that poses significant threats to both public health and national security. Anthrax...
Published: 1/27/2026   |   Inventor(s): George Georgiou, Brent Iverson, Barrett Harvey
Keywords(s):  
Category(s): Life sciences > Immunology, Life sciences > Therapeutics
Engineered enzyme therapy for targeted reduction of plasma homocysteine in metabolic disorders
This technology is a specially engineered human enzyme, modified and PEGylated to break down excess homocysteine in the blood, offering a new treatment for homocystinuria and hyperhomocysteinemia with improved effectiveness and dosing flexibility. Background Homocystinuria and hyperhomocysteinemia are metabolic disorders characterized by elevated...
Published: 1/27/2026   |   Inventor(s): Scott Rowlinson, Christopher Daige, Leslie Sloan
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule
Regulated Gene Expression During Differentiation of Mature T Cells (UCLA Case No. 2022-147)
UCLA researchers from the Department of Pathology & Laboratory Medicine have developed a process to genetically modify stem cells to express transgenes in a regulated, stage-specific manner, avoiding the negative consequences of transgene expression during T cell development. Contact UCLA Technology Development Group for more information.
Published: 1/27/2026   |   Inventor(s): Gay Crooks, Donald Kohn
Keywords(s):  
Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases
Enhancing T Cell Production in Vitro From Stem and Progenitor Cells (UCLA Case No. 2022-257)
UCLA researchers from the Department of Pathology and Laboratory Medicine have developed an innovative differentiation method to increase T cell production for T cell immunotherapy. Contact UCLA Technology Development Group for more information.
Published: 1/27/2026   |   Inventor(s): Gay Crooks, Christopher Seet
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
Insulin Crystals Removal Platform
Description: A platform technology for improving insulin delivery by removing insulin-derived fibrils through polyester membrane filtration. This invention employs membrane filters integrated into insulin delivery systems to selectively remove insulin-derived fibrils (IDFs) from insulin formulations. By filtering out fibrils while preserving active...
Published: 1/27/2026   |   Inventor(s): Ulrike Klueh
Keywords(s):  
Category(s): Technology Category > Biomedical, Technology Category > Devices, Technology Category > Drug Delivery, Technology Category > Life Science, Technology Category > Medical Devices
Systems and Methods for 3D Volumetric Mesh Transformer
Invention Description Conducting learning-based models on large-scale unstructured geometric data, particularly volumetric 3D meshes, remains a significant challenge. While previous methods have employed graph convolutional approaches, they suffer from high space complexity, limiting efficient mini-batch training, as well as fixed short-range feature...
Published: 1/27/2026   |   Inventor(s): Yalin Wang, Mohammad Farazi, Yanxi Chen
Keywords(s):  
Category(s): Artificial Intelligence/Machine Learning, Computing & Information Technology, Imaging, Medical Imaging, Neurodegenerative Disease Technologies, Life Science (All LS Techs)
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