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Search Results - lizhao+you
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Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use
" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are...
Published: 5/13/2025
|
Inventor(s):
Li Niu
,
Zhen Huang
Keywords(s):
Technologies
Category(s):
Technology Classifications > Screens and Assays
,
Technology Classifications > Research Tools and Reagents
,
Campus
,
Campus > University at Albany
Potent and Selective Inhibition of a Single AMPA Receptor Subunit by an RNA Aptamer
Inhibitors of AMPA type glutamate ion channels for the treatment of neurological disorders such as ALS, Alzheimer's, and Parkinson's. Background: Ionotropic glutamate receptors (iGluRs) play special roles in brain activities, such as memory and learning, and have been implicated in a variety of neurological diseases, such as post-stroke cellular...
Published: 5/13/2025
|
Inventor(s):
Li Niu
,
Zhen Huang
,
Yan Han
,
Congzhou Wang
,
Jae Seon Park
Keywords(s):
RNA
,
Technologies
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Campus
,
Campus > University at Albany
Drug Candidate for ALS
RNA aptamers that focus on glutamate receptors are a potential drug candidate for amyotrophic lateral sclerosis (ALS). Background: Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, is a progressive neuromuscular disease for which there is no cure. The disease attacks motor neurons that run from the brain to the spinal cord...
Published: 5/13/2025
|
Inventor(s):
Li Niu
,
Zhen Huang
Keywords(s):
ALS
,
amyotrophic lateral sclerosis
,
aptamers
,
drug design
,
Lou Gehrig's disease
,
MND
,
motor neurone disease
,
RNA
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Campus > University at Albany
Enhanced aqueous fluid saturation with gases in wellbores
Background Resource extraction, carbon storage, and enhanced oil recovery increasingly demand advanced methods for achieving high levels of gas saturation in fluids under subsurface conditions, yet current techniques struggle with efficient and precise control. Traditional approaches often rely on co-injection methods that mix gases and liquids at...
Published: 5/12/2025
|
Inventor(s):
Ryosuke Okuno
,
Tesleem Lawal
,
Hao Wang
Keywords(s):
Category(s):
Physical sciences > Energy > Oil & gas > Enhanced oil recovery
VITRUALGENOME, A VIRTUAL REALITY IMMERSIVE SYSTEM
VAlue proposition A virtual reality immersive system that enables users to visualize, explore, and analyze 3D genomes and their associated biochemical features. Combining VirtualGenome with Tensor-FLAMINGO and 3DVarientVision creates a technology that provides a high-resolution image of the altered 3D structure resulting from a genetic variant, decodes...
Published: 4/9/2025
|
Inventor(s):
Jianrong Wang
,
Andre Popovitch
,
Hao Wang
Keywords(s):
Category(s):
Biotechnology
,
Computer Software
,
Education & Training
HIGH-RESOLUTION RECONSTRUCTION OF SINGLE-CELL 3D CHROMOSOMAL STRUCTURES
VAlue proposition The dynamic 3D spatial structure of chromosomes has variations across cells of different types and between cells of the same type. This structural variation between single cells plays an important role in regulating single-cell specific transcription and epigenetic landscapes. Computationally reconstructing chromosomal 3D structure...
Published: 4/9/2025
|
Inventor(s):
Jianrong Wang
,
Jianliang Qian
,
Hao Wang
Keywords(s):
Category(s):
Biotechnology
,
Computer Software
Method for Vascular Regeneration and Wound Treatment
Asset/Technology Type Therapeutic Strategy Description of Invention The invention is a therapeutic approach for modulating cellular trans-differentiation and potentially angiogenesis by modulating O-glcnacylation (GlcNAc) of proteins, to treat various conditions. The inventors used existing small molecules to prove the concept in vitro and in vivo....
Published: 5/21/2025
|
Inventor(s):
John Cooke
,
Li Lai
Keywords(s):
Category(s):
Clinical Area
,
Clinical Area > Cardiovascular
,
Research Area > Heart and Vascular
,
Research Area > Regenerative Medicine
,
Technology Classifications
,
Technology Classifications > Other
Method for Simultaneous Nonlinear Frequency Conversion and Spectro-Temporal Shaping of Lightwaves (Case No. 2024-254)
Summary: Researchers in UCLA’s Department of Electrical and Computer Engineering have developed an innovative method for nonlinear frequency conversion and spectro-temporal shaping. This technique operates efficiently at high power levels and offers optical tunability, enabling a wide range of customizable applications. Background: Light frequency...
Published: 2/14/2025
|
Inventor(s):
Sergio Carbajo
,
Hao Zhang
Keywords(s):
Adaptive Optics
,
Frequency conversion
,
frequency modulation
,
high-frequency signals
,
high-powered laser systems
,
nonlinear dynamics
,
Nonlinear Optics
,
non-linear optics
,
Nonlinear Optics Molecular Dynamics
,
Optical computing
,
Optics
,
Optoelectronics Waveguide (Electromagnetism)
,
Phase (Waves)
,
Quantum Computer
,
Waveguide
,
Waveguide Light
Category(s):
Electrical > Signal Processing
,
Electrical > Quantum Computing
,
Electrical
,
Optics & Photonics > Spectroscopy
,
Optics & Photonics
,
Optics & Photonics > Lasers
Ion-Conductive and Electron-Conductive Open Lattice Catalyst Support Framework (Case No. 2025-090)
Summary: UCLA researchers from the Department of Materials Science and Engineering have developed a novel catalyst support framework for proton-exchange membrane fuel cells. Background: Proton-exchange membrane fuel cells (PEMFCs) are promising technologies for clean energy applications due to their high efficiency and reduced emissions. These devices...
Published: 2/14/2025
|
Inventor(s):
Yu Huang
,
Ao Zhang
Keywords(s):
Category(s):
Energy & Environment
,
Energy & Environment > Energy Efficiency
,
Materials
Acquisition – Software to Control Acquisition of Images for Near-Earth Object Survey Operations
The Acquisition subsystem in the Catalina Sky Survey (CSS) software suite manages the operation of telescopes and instruments to capture data on asteroids and Near-Earth Objects (NEOs). Once areas of the sky are selected for observation, Acquisition takes over, accepting the input from the Planner subsystem and coordinating the telescope, camera, and...
Published: 12/9/2024
|
Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
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