Search Results - lu+lu

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Highly sensitive pressure sensor for diverse applications
A flexible, highly sensitive pressure sensor combines resistive and capacitive elements using a porous carbon nanotube–Eco flex material. It accurately detects a wide range of pressures, is easy to fabricate, and suits diverse applications like medical monitoring and environmental sensing. Background Pressure sensing technology plays a crucial...
Published: 1/8/2025   |   Inventor(s): Nanshu Lu, Kyoung-Ho Ha
Keywords(s):  
Category(s): Life sciences > Medical technology
Degrader Molecules for hRpn13Pru, PCLAF, RRM2 and Other KEN Box-containing Proteins
Summary: The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for three small molecules that target hRpn13, an overexpressed protein in certain cancers. Description of Technology: Over 35,000 new cases of multiple myeloma are diagnosed each year in the US. Standard of care and experimental therapies include...
Published: 12/20/2024   |   Inventor(s): Kylie Walters, Xiuxiu Lu
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Collaboration Sought > Licensing
Modified kynureninase enzymes for cancer therapy
This invention describes modified kynureninase enzymes, particularly human enzymes, for degrading kynurenine. These enzymes can be used in compositions and methods for treating cancer by depleting kynurenine levels. Background Cancer immunotherapy has emerged as a promising approach to treating a wide range of malignancies. The goal of immunotherapy...
Published: 11/5/2024   |   Inventor(s): George Georgiou, Everett Stone, John Blazeck, Nicholas Marshall, Wei-Cheng Lu
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Gene therapy
Individualized intranasal delivery system for direct pharmaceutical administration to the brain
The technology involves a customizable nasal delivery device for precise administration of medications directly to the brain, bypassing traditional barriers. It uses imaging techniques for optimal placement, enhancing drug delivery efficiency and minimizing systemic side effects. Background Oral administration remains the predominant method for drug...
Published: 10/11/2024   |   Inventor(s): Hugh Smyth, Robert Williams, Zachary Warnken, Yang Lu
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Medical technology > Medical devices
Needle Guide and Holder for Percutaneous Access to Subcutaneous and Deep Tissue Targets (Case No. 2024-207)
Summary: UCLA researchers in the Department of Interventional Radiology have developed a device to secure a needle during image-guided, minimally-invasive procedures, mitigating unwanted migration between scans. Background: Minimally invasive procedures in medicine are becoming increasingly popular, taking the place of traditional open surgeries....
Published: 10/25/2024   |   Inventor(s): David Lu
Keywords(s): CT, image-guided surgery, intervention, Medical Device, MRI, Radiology, Surgery
Category(s): Medical Devices > Surgical Tools
Needle Clamp With Rolling Sphere (Case No. 2024-211)
Summary: UCLA researchers from the Department of Radiology have developed a novel needle-holding clamp for use during minimally invasive procedures. Background: Minimally invasive procedures are now widely used for diagnosing and treating subcutaneous and deep tissue targets. These procedures use percutaneous needle insertions rather than large incisions...
Published: 11/5/2024   |   Inventor(s): David Lu
Keywords(s): femtech medical device, Invasiveness Of Surgical Procedures, Medical Device, medical device cardiac monitoring, Medical Device Poly(Methyl Methacrylate), Medical Devices and Materials, Microneedle array, minimally invasive device, minimally invasive procedures, needle guidance, needle holder, noninvasive, non-invasive, non-invasive drug monitoring, non-invasive imaging, non-invasive monitoring, Smart medical device, tissue targeting accuracy, wearable medical device, wearable medical devices
Category(s): Medical Devices, Medical Devices > Surgical Tools
Enhanced cancer treatment through methionine depletion
The invention involves engineering a modified human cystathionine-γ-lyase enzyme to degrade methionine, an amino acid essential for cancer cell growth. This modified enzyme, with specific amino acid substitutions, offers enhanced catalytic activity, stability, and reduced immunogenicity, making it suitable for cancer treatment by depleting methionine...
Published: 9/13/2024   |   Inventor(s): George Georgiou, Everett Stone, Wei-Cheng Lu
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Therapeutics > Gene therapy
Engineered enzymes for cystinuria treatment
The invention describes engineered primate cystathionine-gamma-lyase (CGL) enzymes with specific amino acid modifications to efficiently degrade L‑cystine and L-cysteine. These enzymes are designed to treat cystinuria by reducing cystine levels in the body, preventing cystine stone formation. Background Cystinuria is a genetic disorder caused by mutations...
Published: 11/5/2024   |   Inventor(s): Everett Stone, Wei-Cheng Lu, Christos Karamitros
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene therapy
Using Artificial Intelligence To Predict The Risk Of Age-Related Macular Degeneration
Summary: The National Eye Institute seeks research co-development partners and/or licensees for a deep learning algorithm that can predict the probability of progression to late age-related macular degeneration. Description of Technology: In 2024, an estimated 200 million people worldwide suffer from age-related macular degeneration (AMD); projected...
Published: 12/23/2024   |   Inventor(s): Emily Chew, Zhiyong Lu, Tiarnan Keenan, Wai Wong, Qingyu Chen, Elvira Agron
Keywords(s):  
Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Licensing
Enhancing Fairness Through Aleatoric Uncertainty
Background In recent years, advancements in machine learning have revolutionized various domains, but concerns about bias and unfairness in automated decision-making systems have gained significant attention. One of the causes of unfairness in AI systems is the reliance on training data. Aleatoric uncertainty refers to the inherent randomness or variability...
Published: 8/7/2024   |   Inventor(s): Anique Tahir, Lu Cheng, Huan Liu
Keywords(s): Artificial Intelligence, Machine Learning
Category(s): Physical Science, Computing & Information Technology, Intelligence & Security
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