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Search Results - lu+lu
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Enhanced cancer treatment through methionine depletion
The invention involves engineering a modified human cystathionine-γ-lyase enzyme to degrade methionine, an amino acid essential for cancer cell growth. This modified enzyme, with specific amino acid substitutions, offers enhanced catalytic activity, stability, and reduced immunogenicity, making it suitable for cancer treatment by depleting methionine...
Published: 9/13/2024
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Inventor(s):
George Georgiou
,
Everett Stone
,
Wei-Cheng Lu
Keywords(s):
Category(s):
Life sciences > Metabolic engineering
,
Life sciences > Therapeutics > Gene therapy
Engineered enzymes for cystinuria treatment
The invention describes engineered primate cystathionine-gamma-lyase (CGL) enzymes with specific amino acid modifications to efficiently degrade L‑cystine and L-cysteine. These enzymes are designed to treat cystinuria by reducing cystine levels in the body, preventing cystine stone formation. Background Cystinuria is a genetic disorder caused by mutations...
Published: 9/6/2024
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Inventor(s):
Everett Stone
,
Wei-Cheng Lu
,
Christos Karamitros
Keywords(s):
Category(s):
Life sciences > Therapeutics > Gene therapy
Using Artificial Intelligence To Predict The Risk Of Age-Related Macular Degeneration
Summary: The National Eye Institute seeks research co-development partners and/or licensees for a deep learning algorithm that can predict the probability of progression to late age-related macular degeneration. Description of Technology: In 2024, an estimated 200 million people worldwide suffer from age-related macular degeneration (AMD); projected...
Published: 8/14/2024
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Inventor(s):
Emily Chew
,
Zhiyong Lu
,
Tiarnan Keenan
,
Wai Wong
,
Qingyu Chen
,
Elvira Agron
Keywords(s):
Category(s):
Application > Diagnostics
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Eye / Ear / Nose / Throat
Enhancing Fairness Through Aleatoric Uncertainty
Background In recent years, advancements in machine learning have revolutionized various domains, but concerns about bias and unfairness in automated decision-making systems have gained significant attention. One of the causes of unfairness in AI systems is the reliance on training data. Aleatoric uncertainty refers to the inherent randomness or variability...
Published: 8/7/2024
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Inventor(s):
Anique Tahir
,
Lu Cheng
,
Huan Liu
Keywords(s):
Artificial Intelligence
,
Machine Learning
Category(s):
Physical Science
,
Computing & Information Technology
,
Intelligence & Security
ARPLA: a revolutionary glycoRNA imaging tool with precision and power
Background/problem Glycosylated RNAs (GlycoRNAs) are a newly discovered class of molecules involved in glycosylation. They have been found on the surfaces of various cell types, organisms, and species, further advancing the role of RNA in biological processes. Despite this, our knowledge of glycoRNAs and their functions remains limited, primarily...
Published: 7/26/2024
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Inventor(s):
Yi Lu
,
Yuan Ma
,
Weijie Guo
,
Quanbing Mou
Keywords(s):
Category(s):
Life sciences > Research tools > Tool/assay/screening platform
“Bio-Flex”: advanced formulation for sustainable stereolithography (SLA)
Background/problem Stereolithography (SLA) 3D printing has transformed the biomedical field with creation of highly accurate, patient-specific medical devices such as tissue scaffolds, implants, and surgical tools. This technology leverages computer-aided design and medical imaging data to produce structures with precise geometries at submicron scales....
Published: 7/26/2024
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Inventor(s):
Mohammed Maniruzzaman
,
Yu Zhang
,
Anqi Lu
Keywords(s):
Category(s):
Life sciences > Medical technology > Medical devices
,
Life sciences > Therapeutics > Drug delivery
Cholesterol-modified Sphingomyelin Lipid Bilayer for Drug and Gene Delivery
This invention is a new type of lipid vesicle or liposome that can be used to encapsulate drugs and genes for therapeutic applications. It improves upon existing liposome formulations in its increased stability, subsequent increased circulation time, and effectiveness as a nanocarrier. Background: For many years, therapeutic drugs were released...
Published: 7/24/2024
|
Inventor(s):
Jianqin Lu
,
Zhiren Wang
,
Wenpan Li
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Drug Delivery
,
Technology Classifications > Healthcare Portfolios > Oncology
Targeted Organ or Multiple Organ Delivery of mRNA with Ionizable Amphiphilic Janus Dendrimers
A library of easily synthesized ionizable amphiphilic Janus dendrimer (IAJD) compounds that deliver mRNA either to targeted organs or multiple organs, depending on the IAJD design. Problem: Four-component lipid nanoparticles (LNPs) are the benchmark synthetic vector for the delivery of mRNA. Despite their high biosafety, low toxicity, and immunogenicity,...
Published: 7/23/2024
|
Inventor(s):
Virgil Percec
,
Drew Weissman
,
Juncheng (Luke) Lu
,
Elena Atochina-Vasserman
,
Devendra Maurya
,
Dipankar Sahoo
Keywords(s):
Drug Delivery
,
Platform Technology
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Vaccines
A Wearable Multi-Functional Ophthalmic Device for Monitoring Oculomotor Components
The invention is a wearable ophthalmic device designed to monitor various aspects of eye function crucial for clear vision. It combines several diagnostic capabilities into a single, user-friendly device. These capabilities include capturing detailed images of the retina (fundus), tracking eye movements accurately, and measuring how well the eyes adjust...
Published: 7/22/2024
|
Inventor(s):
Hong Hua
,
Yanzhao Lu
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics > Ophthalmology
,
Technology Classifications > Imaging & Optics > Lens & System Design
,
Technology Classifications > Imaging & Optics > Displays
Quercetin as substrate for antiviral treatment against Hepatitis C virus infection (UCLA Case No. 2023-003)
UCLA researchers in the Department of Pathology and Hematology have developed a novel antiviral treatment for Hepatitis C virus based on the metabolic modulating properties of dietary compound Quercetin. BACKGROUND: Hepatitis C virus (HCV) is responsible for 180 million infections worldwide and over 12,000 deaths in the U.S. each year. Despite most...
Published: 5/16/2024
|
Inventor(s):
Nu Lu
Keywords(s):
antivirals
,
hepatitis
,
immune metabolism
,
Inflammation
,
liver disease
Category(s):
Therapeutics > Infectious Diseases
,
Therapeutics > Inflammation And Inflammatory Diseases
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