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WAVE: Wearable Analog-processed Vascular Echography
Background The field of ultrasonic imaging is crucial for non-invasive medical diagnostics, offering detailed insights into internal body structures and physiological processes. There is a significant need for continuous, long-term monitoring of hemo­dynamic parameters, such as blood volume and vessel dynamics, particularly for early detection...
Published: 12/12/2025   |   Inventor(s): Nanshu Lu, Philip Tan
Keywords(s):  
Category(s): Life sciences > Medical technology > Medical devices
DNAzyme-seq: a single-cell metal ion and transcriptome profiling platform
Background Metal ions such as zinc, copper, and calcium play indispensable roles in nearly every facet of cellular physiology, from enzymatic catalysis to signal trans­duction. However, conventional single-cell transcriptomics has largely over­looked the contribution of metal cofactors to gene expression, metabolism, and disease progression....
Published: 12/4/2025   |   Inventor(s): Yi Lu, Mandira Banik, Valeria Garcia, Ishika Rashed
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology > Genomics/genetics
Metal organic framework membranes for ion transport and separation
Background Ion-selective separation membranes play a critical role in applications such as water purification, energy storage, and chemical processing. These tech­nologies are essential for tackling global challenges like clean water scarcity, efficient energy utilization, and sustainable industrial processes. Traditional ion separation methods,...
Published: 12/3/2025   |   Inventor(s): Huacheng Zhang, Xingya Li, Huanting Wang, Jun Lu, Anita Hill, Benny Freeman
Keywords(s):  
Category(s): Physical sciences > Materials > Membranes
Hyperbranched Polyglycerol Encapsulated Proteins for Oral Protein Delivery (Case No. 2012-425)
Patent Abstract: Methods for modifying therapeutic agents such as therapeutic biomolecules, such as proteins for improved oral, rectal or transmucosal delivery, as well as compositions made using such methods and methods of administering such compositions to a subject, are disclosed. Specifically, the therapeutic agents are conjugated to hyperbranched...
Published: 12/1/2025   |   Inventor(s): Yunfeng Lu, Juanjuan Du, Jie Li, Yang Liu
Keywords(s):  
Category(s): Platforms > Drug Delivery
Balloon Catheter for Thermal Ablation Protection (Case No. 2024-210)
Summary UCLA researchers have developed a novel planar balloon catheter that reliably separates and protects organs during thermal ablation procedures. By creating a sheet-like thermal barrier, the device mitigates unintended injury to nearby healthy tissues—particularly the stomach and bowel—thereby enabling safer and more effective treatment...
Published: 9/26/2025   |   Inventor(s): David Lu
Keywords(s): catheter, Catheterization, Swan-Ganz catheter
Category(s): Medical Devices, Medical Devices > Surgical Tools, Therapeutics > Oncology, Therapeutics > Renal, Therapeutics
Method and Apparatus for Tunable Visible and Infrared Laser Generation (Case No. 2023-249)
Summary UCLA researchers have developed a versatile photonic RF waveform generator based on a silicon-nitride (Si₃N₄) chip that achieves a wide tuning range of repetition rate and generates high-quality, tunable ultrafast pulses. This system uses a fiber-amplified seed followed by a noncollinear optical parametric amplifier (NOPA) to produce signal...
Published: 9/12/2025   |   Inventor(s): Sergio Carbajo, Keith Wernsing, Ying-Ying Lu
Keywords(s):  
Category(s): Electrical, Optics & Photonics, Optics & Photonics > Lasers
Point of Care Ultrasound (POCUS) Real-Time 3D or Multi-Plane 2D Ultrasound Imaging Based on Bessel or Focused Beam Steered by a Reflector Driven by Electromagnets or Micro-Motors
Project ID: TECH-2025-34 Background: Despite that there are many companies that develop POCUS devices, many have so many problems with good images, short battery life, heating issues and no 3D images. Traditionally, a one-dimensional (1D) array transducer is used for two-dimensional (2D) imaging, where the transducer and its cable are heavy and bulky,...
Published: 10/2/2025   |   Inventor(s): Jian-yu Lu, Samer Khouri
Keywords(s):  
Category(s): Medical Device
Droplet-Based Single-Cell Epigenomic Assay
THE CHALLENGE A major challenge in single-cell DNA methylation profiling lies in the inefficiency and high cost of current methods, which rely on labor-intensive, plate- or tube-based workflows that are difficult to scale. These traditional approaches not only require multiple manual steps and expensive reagents but also suffer from significant DNA...
Published: 10/20/2025   |   Inventor(s): Chang Lu, Qiang Zhang
Keywords(s):  
Category(s): Technology Classifications > Biotechnology, Technology Classifications > Biomedical
Biocompatible photoenzymatic system for selective C–H fluorination
Background C–H fluorination plays a central role in pharmaceutical and agrochemical synthesis, as the introduction of fluorine often enhances a molecule's metabolic stability, potency, and bioavailability. Over 20% of approved drugs contain fluorinated functional groups, underscoring the demand for efficient and selective fluorination methods....
Published: 11/25/2025   |   Inventor(s): Yi Lu, Yu Zhou
Keywords(s):  
Category(s): Life sciences > Metabolic engineering
DNA-based sensors for live-cell mapping of metabolite- and metal ion-protein interactions
Background Understanding how metabolites and metal ions interact with proteins inside living cells is essential for decoding cellular signaling, metabolic regulation, and disease mechanisms. These small molecules function as cofactors, second messengers, and allosteric regulators, orchestrating critical pathways that govern cell behavior. However,...
Published: 11/25/2025   |   Inventor(s): Yi Lu, Mandira Banik
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology > Genomics/genetics
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