Search Results - jacob+brenner

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Nanoparticles for Precise & Targeted Treatment of Neurological Conditions
Problem: Acute ischemic stroke (AIS) is the second leading cause of death worldwide, affecting around 600,000 Americans annually. However, pharmacological treatment of AIS is difficult due to ineffective and nonspecific targeting to blood brain barrier epitopes via intravenous administration. Over 100 drugs have been tried and failed in clinical trials...
Published: 2/20/2025   |   Inventor(s): Oscar Marcos Contreras, Jacob Brenner, Vladimir Muzykantov, Jia Nong, Patrick Glassman, Drew Weissman, Sahiley Reyes-Esteves
Keywords(s): Drug Delivery, Inflammation, Nanotechnology, Neurology
Category(s): Technology Classifications > Therapeutics
Strategies for Mitigating Acute Side Effects of Lung-Targeted Nanocarriers
Approaches and Design Techniques to Alleviate Coagulation-Related Acute Side Effects of Lung-Targeted Nanocarriers Problem: Lipid nanoparticles (LNPs) play a crucial role in drug delivery, enabling targeted drug administration to specific tissues. LNPs tailored for lung-specific delivery often incorporate cationic (positively charged) lipids. Unfortunately,...
Published: 6/26/2024   |   Inventor(s): Jacob Brenner, Vladimir Muzykantov, Jacob Myerson, Oscar Marcos Contreras, Marco Zamora, Serena Omo-Lamai
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Pulmonary
Category(s): Technology Classifications > Therapeutics
Novel Nanoparticle Composition Targeting Marginated Leukocytes
Problem: Acute inflammatory diseases, including sepsis, pneumonia, and acute respiratory distress syndrome (ARDS), account for over 1.5 million hospitalizations and 300,000 deaths per year in the US. These diseases all share a common cellular player known as marginated leukocytes. Marginated leukocytes are white blood cells that accumulate in the...
Published: 1/12/2024   |   Inventor(s): Jacob Myerson, Jacob Brenner, Vladimir Muzykantov, Landis Walsh, Priyal Patel
Keywords(s): COVID-19, Drug Delivery, Infectious Disease, Inflammation, Nanotechnology, Pulmonary
Category(s): Technology Classifications > Therapeutics
Improving Drug Delivery Using Red Blood Cell Hitchhiking
Problem: A major challenge in drug delivery is ensuring that the drug reaches the target organ at a concentration sufficient to treat the disease. This is particularly problematic for acute illnesses of the vasculature, such as acute respiratory distress syndrome (ARDS), ischemic stroke, and myocardial infarction. In these diseases, patients are often...
Published: 1/11/2024   |   Inventor(s): Jacob Brenner, Vladimir Muzykantov
Keywords(s): COVID-19
Category(s): Technology Classifications > Therapeutics