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TRP: A Mouse Model of Limb Girdle Muscular Dystrophy Type 2A (R1/D4) (UCLA Case No. 2021-171)
UCLA researchers in the Department of Neurology have developed a novel mouse model for limb girdle muscular dystrophy, a disorder that causes muscle weakness in the limbs and hip area. BACKGROUND: Limb-Girdle Muscular Dystrophy Type 2A (LGMDR1) is a genetic neuromuscular disorder characterized by progressive muscle weakness, primarily affecting muscles...
Published: 7/30/2025   |   Inventor(s): Melissa Spencer
Keywords(s):  
Category(s): Life Science Research Tools > Animal Models
Regioselective 1,2-Dearomatization of Functionalized Azines by Organolanthanide Catalysts
NU2014-129 INVENTORS Tobin Marks* Alexander Dudnik Massimiliano Delferro Victoria Weidner SHORT DESCRIPTION This invention describes a catalytic process for the regioselective 1,2-dearomatization of functionalized azines using an organolanthanide catalyst and pinacolborane (HBpin). It offers a streamlined approach to key intermediates for pharmaceuticals...
Published: 7/30/2025   |   Inventor(s):  
Keywords(s): Catalyst, Chemicals, Manufacturing/Processing, Materials
Category(s): Physical Sciences > Materials and Industrial Processes
Novel self-healing commodity copolymers based on 2-ethylhexyl acrylate
NU2023-240 INVENTORS John Torkelson* Tong Wang SHORT DESCRIPTION This invention describes a new class of random copolymers that exhibit autonomous self-healing behavior at room temperature. The copolymers, derived entirely from commodity comonomers including 2-ethylhexyl acrylate, fully recover their material properties after damage. BACKGROUND The...
Published: 7/30/2025   |   Inventor(s):  
Keywords(s): Materials, Polymer, Smart/Functional materials
Category(s): Physical Sciences > Materials and Industrial Processes
Multi-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 7/29/2025   |   Inventor(s): Dino Di Carlo, Alyssa Arnheim, Michael Mellody, Yuta Nakagawa, Lily Shang
Keywords(s): Assay, B Cell, barcode, Bioassay, biological assays, Biomarker, biomarkers, Biomaterial, capping particles, CAR-T cell platform, CAR-T cell therapy, cavities, cavity-containing particles, Cell and tissue culture, cell encapsulation, cell engineering, cell imaging, cell mapping, cell sorting, cell type identification, cell-based therapy, centrifugation, confinement, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, Drug, Drug Delivery, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, Immunoassay, Immunoassay Sense (Molecular Biology), Microfluidics, Microfluidics And Mem's, Microfluidics Nanosphere, microparticles, moieties, Nanoparticle, single cell analysis, single cell analysis and testing, Single cell data, single-cell resolution, single-cell trapping
Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Platforms
Covalent Adaptable Networks with Associative Siloxane Exchange Enabled by Amide-Based Internal Catalysis
NU2025-056 INVENTORS John Torkelson* Tapas Debsharma Nathan Purwanto Tong Wang SHORT DESCRIPTION A technology that introduces internally catalyzed siloxane dynamic chemistry in covalent adaptable networks (CANs) through amide-based catalysis to produce recyclable and reprocessable polymers with maintained cross-link density at elevated temperatures. BACKGROUND Replacing...
Published: 7/29/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Physical Sciences > Materials and Industrial Processes
Recyclable and Depolymerizable Polymer Network Materials via Thiourethane Dynamic Chemistry
NU2019-126 INVENTORS John Torkelson* Lingqiao Li Xi Chen SHORT DESCRIPTION A class of reprocessable, PU-like polymer networks synthesized via thiourethane dynamic chemistry that allow for complete cross-link density recovery and offer the potential for monomer recovery under mild conditions. BACKGROUND Traditional cross-linked polyurethane...
Published: 7/29/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Physical Sciences > Materials and Industrial Processes
Fusion Protein for Development of Transgenic Resistance to Lepidopteran Pests
A Specific, Eco-Friendly Approach to Pest Control Using Genetically Engineered Biopesticides A fusion protein comprised of a densovirus coat protein, a proline-rich linker, and an insect-specific neurotoxin allows for the development of transgenic crops with resistance to lepidopteran (caterpillar) pests. Insects cause agricultural loss and economic...
Published: 7/30/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Technology Classifications > Agricultural > Insect Control, Technology Classifications > Agricultural > Therapeutics
Production of Spin-Polarized Molecular Beams via Microwave or Infrared Rotational Excitation
Achieving high nuclear spin polarization in molecules is critical for enhancing the efficiency of nuclear fusion reactors and significantly boosting signals in nuclear magnetic resonance (NMR) and medical imaging. However, existing methods face substantial limitations in meeting the demand for large quantities of highly polarized molecules. Conventional...
Published: 7/29/2025   |   Inventor(s): Ahmed Diallo, Jason Parisi, Theodore Rakitzis, Chrysovalantis Kannis
Keywords(s): fusion
Category(s): Plasma/Fusion
Nutrition Screening Algorithm for Cleft Repair
​ Invention Summary: Cleft lip and palate are common craniofacial birth defects affecting approximately one in 700 live births. Early intervention via surgical repair can improve appearance, speech, hearing, and psychosocial development. Models for fast identification and surgical intervention for affected infants and children, including models...
Published: 7/28/2025   |   Inventor(s): Melissa Wallinga, Laura Byham-Gray, Jane Ziegler, Alainn Bailey
Keywords(s):  
Category(s): Technology Classifications > Education, Technology Classifications > Software & Copyright
T Cell Receptor Targeting HPV6 E2 and a Panel of Cos7 Cells Expressing Different HLA Class I Proteins for Use in Validation and Potency Studies
Summary: The National Cancer Institute (NCI) seeks licensees for this invention comprising (1) a novel T cell receptor (TCR) specific to the E2 protein of Human papillomavirus (HPV) type 6 in the context of the human leukocyte antigen, HLA-B55, and (2) a panel of Cos7 cells expressing different HLA proteins for validation of T cell responses in immunotherapies...
Published: 7/28/2025   |   Inventor(s): Clint Allen, Scott Norberg
Keywords(s):  
Category(s): Application > Research Materials, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, Collaboration Sought > Licensing
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