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Simple, Field-Usable Fluorescence-Based Isothermal LAMP Assay for the On-Site Diagnosis of Malaria

CDC researchers have developed improved Loop-Mediated Isothermal Amplification (LAMP) assays for the nucleic acid-based diagnosis of malaria in field settings. The approach employs Plasmodium genus-specific LAMP primers and a portable tube scanner to run the LAMP reaction and measure fluorescence signal (e.g., SYBR green) as a measure of DNA amplification...

Published: 10/28/2024 | Inventor(s): Allison Demas, Naomi Lucchi, Venkatachalam Udhayakumar

Keywords(s): assay, Based, CDC Docket Import, CDC Docket Import CDC Prosecuting, CDCRM, DA2XXX, DAXXXX, DDXXXX, DEVELOPING, Development, Diagnosis, diagnostic, DXXXXX, Field-usable, Fluorescence, Isothermal, ivd, LAMP, LIMITED-RESOURCE, LOW INPUT, Malaria, Mosquito, Mosquitoes, nucleic acid, NUCLEIC ACID DETECTION, PCR ALTERNATIVE, real time, REAL-TIME, SIMPLE, travel, traveler, travelers, VBXXXX, Vector-borne, Vector-borne diseases, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, YBXXXX, Zoonotic

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Occupational Safety and Health, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Consumer Products

Recombinant Polypeptides for Clinical Detection of Taenia solium and Diagnosis of Cysticercosis

CDC scientists have developed synthetic/recombinant polypeptides that can be used for the creation of inexpensive, high-quality cysticercosis diagnostic assays. Taenia solium is a species of pathogenic tapeworm. Intestinal infection with this parasite is referred to as taeniasis and it is acquired by ingestion of T. solium cysticerci found in raw...

Published: 10/28/2024 | Inventor(s): Ryan Greene, Patricia Wilkins, Kathy Hancock, Victor Tsang

Keywords(s): ANTIGEN, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DPDM, Cloned, Compositions, DA2XXX, DAXXXX, DETECTING, diagnostic, DXXXXX, I-031-98, I-031-99, Larval, Methods, SOLIUM, TAENIA, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WBXXXX, WFXXXX, WJXXXX, WMXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, Application > Diagnostics, ResearchProducts > Antibodies, Application > Research Materials, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Oncology

Methods for the Simultaneous Detection of Multiple Analytes

CDC researchers have developed a method of simultaneously detecting and distinguishing multiple antigens within a biological sample. Epidemiological and vaccine studies require species serotype identification. Current methods of serotyping are labor intensive and can easily give subjective, errant results. This technology utilizes serotype specific...

Published: 10/28/2024 | Inventor(s): George Carlone, Joseph Martinez

Keywords(s): AA5XXX, AAXXXX, ANALYTES, AXXXXX, Bead, Beads, CA1BXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA1XXX, DA2XXX, DA3XXX, DA4AXX, DA4BXX, DA4XXX, DA5XXX, DAXXXX, Detection, flow cytometer, flow cytometry, IAXXXX, IMMUNOASSAY, Methods, MULTIPLE, SIMULTANEOUS, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WIXXXX, WMXXXX, XAXXXX, XCXXXX, XHXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Application > Consumer Products, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, Application > Research Materials, Application > Diagnostics, ResearchProducts > Antibodies, Application > Occupational Safety and Health

Methods of Retaining Methylation Pattern Information in Globally Amplified DNA

CDC researchers have developed a novel method that generates globally amplified DNA copies retaining parental methylation information; making accurate DNA-archiving for methylation studies much more feasible and cost-effective than undertaking such an endeavor with alternate technologies. This unique approach eliminates a significant bottleneck in...

Published: 10/28/2024 | Inventor(s): Elizabeth Unger, Mangalathu Rajeevan

Keywords(s): AA5XXX, AAXXXX, AC4XXX, AC5XXX, AC6XXX, ACXXXX, AG2XXX, Amplified, AXXXXX, CC1XXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DA2XXX, DA3XXX, DA4AXX, DA4BXX, DA4XXX, DA5XXX, DAXXXX, DDXXXX, DNA, GAXXXX, GCXXXX, Globally, Method, Methylation, NA2BXX, NC3XXX, NC4XXX, NC5XXX, OID-NCEZID-DHCPP, Pattern, RETAINING, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VNXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WIXXXX, WMXXXX, XBXXXX, XCXXXX, XEXXXX, XHXXXX, YBXXXX

Recombinant NIE Antigen from Strongyloides stercoralis

Strongyloides stercoralis is an intestinal nematode endemic that affects an estimated 30 to 100 million people worldwide. Many of these individuals may be asymptomatic for decades. The present invention discloses a NIE recombinant antigen that can be used in improved assays and diagnostics for S. stercoralis infection. The NIE antigen is the only...

Published: 10/28/2024 | Inventor(s): Ravi Varatharajalu, Franklin Neva, Thomas Nutman

Keywords(s): ANTIGEN, DA2XXX, DAXXXX, DDXXXX, DXXXXX, recombinant, S., SS-NIE, Stercoralis

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Infectious Disease

T24 Antigen for Diagnosing or Treating Taenia solium Cysticercosis

In order to develop a simple detection assay for field use, CDC researchers cloned and sequenced the Taenia solium T24 diagnostic protein. The T24 sequences can be used to detect and diagnose T. solium infection or can be formulated into a pharmaceutical composition. T. solium is a species of tapeworm. Intestinal infection with T. solium is referred...

Published: 10/28/2024 | Inventor(s): Fatima Williams, Melinda Yushak, Sowmya Pattabhi, Victor Tsang, Kathy Hancock

Keywords(s): AFXXXX, ANTIGEN, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DPDM, Cysticercosis, DA2XXX, DAXXXX, DB2XXX, DBXXXX, DC2XXX, DCXXXX, Immunodiagnosis, SOLIUM, T24, TAENIA, UBXXXX, UXXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics

Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis

CDC researchers developed a simple target-specific isothermal nucleic acid amplification technique, termed Genome Exponential Amplification Reaction (GEAR). The method employs a set of four primers (two inner and two outer). The outer primer pair targets three specific nucleic acid sequences at a constant 60°C, while the inner pair of primers accelerates...

Published: 10/28/2024 | Inventor(s): Prithiviraj Jothikumar, Vincent Hill, Jothikumar Narayanan

Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC4XXX, AC5XXX, Acids, ACXXXX, amplification, AMPLIFYING, AXXXXX, DA1XXX, DA2XXX, DA3XXX, DA4XXX, DA5XXX, DAXXXX, DXXXXX, Exponential, Gear, Genome, Isothermal, Methods, Nucleic, REACTION, REAGENTS, UBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease, Application > Diagnostics

Transmission-Blocking Malaria Vaccine

There is no vaccine for malaria, and there is growing resistance to existing anti-malarial drugs. Sexual stage-specific antigens are of interest as vaccine candidates because disruption of these antigens would reduce the fertility and, thus, the infectivity of the parasite. This invention claims methods and compositions for delivering a Plasmodium...

Published: 10/28/2024 | Inventor(s): Alvaro Molina-Cruz, Carolina Barillas-Mury

Keywords(s): Anopheles, Critical, DA2XXX, DA5XXX, DAXXXX, DB2XXX, DB5XXX, DBXXXX, DC2XXX, DCXXXX, DD1XXX, DDXXXX, DEXXXX, DXXXXX, FALCIPARUM, Gambiae, Gene, Human, Malaria, Mosquitoes, Pfs47, PLASMODIUM, TRANSMISSION

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials

Diagnostic Assays and Methods of Use for Detection of Filarial Infection

The effort targeting the mosquito borne neglected tropical disease lymphatic filariasis for elimination through mass drug administration by 2020 will require accurate, cost effective methods for detecting early infections. The World Health Organization-recommended immunochromatographic test detects adult Wuchereria bancrofti (Wb) antigen in blood, but...

Published: 10/28/2024 | Inventor(s): Doran Fink, Joseph Kubofcik, Peter Burbelo, Thomas Nutman

Keywords(s): Bancrofitan, Bancrofti, CONTROL, DA2XXX, DAXXXX, DXXXXX, Filariasis, FOLLOWING, Immunodiagnosis, Lymphatic filariasis (Wuchereria bancrofti, Brugia malayi), MOLECULE, Programs, Specific, Successful, Surveillance, Wuchereria

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Diagnostics

Anti-Plasmodium Compositions and Methods of Use

This invention describes methods and compositions of peptides that inhibit the binding of Plasmodium falciparum (P. falciparum) to erythrocytes. Malarial parasites enter the red blood cell through several erythrocyte receptors, each being specific for a given species of Plasmodia. For P. falciparum, the erythrocyte binding antigen (EBA-175) is the...

Published: 10/28/2024 | Inventor(s): David Narum

Keywords(s): DA2XXX, DAXXXX, DB2XXX, DBXXXX, DC2XXX, DCXXXX, DXXXXX, Malaria, Malaria (Plasmodium sp.)

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Vaccines

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