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Transgenic Mice with Constitutively Active M3 Muscarinic Receptor in Islet Beta Cells
Q490L point mutation was introduced into the rat M3 muscarinic receptor cDNA to confer persistent, constitutive (ligand-independent) activity. Expression of the M3 receptor mutant was placed under the control of a 650 bp fragment of the rat insulin promoter II (RIP II) to limit expression to the islet beta cell.
Published: 10/28/2024   |   Inventor(s): Jurgen Wess
Keywords(s): Active, Beta, Cells, CONSTITUTIVELY, IDXXXX, ISLET, IXXXXX, M3, Mice, MUSCARINIC, RECEPTOR, TRANSGENIC
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials
Active Adaptive Detuning Systems to Improve Safety of Interventional Devices
The invention offered for licensing and commercial development is in the field of Interventional Magnetic Resonance Imaging (“iMRI”). More specifically the invention discloses interventional devices in which the heat generated at the device during the imaging process can be controlled to not exceed acceptable levels. Active MRI compatible intravascular...
Published: 10/28/2024   |   Inventor(s): Ozgur Kocaturk
Keywords(s): AA2XXX, AAXXXX, Active, ADAPTIVE, AXXXXX, Detuning, Devices, Interventional, MRI, Patent Category - Mech/Elect/Soft, System
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing
Single Channel MRI Guidewire
The invention offered for licensing and commercial development is in the field of Interventional Magnetic Resonance Imaging (“iMRI”). More specifically the invention discloses a guidewire for magnetic resonance imaging with a single channel design to reduce complexity and to provide conspicuous tip visibility under MRI. In the design of the present...
Published: 10/28/2024   |   Inventor(s): Ozgur Kocaturk, Christina Saikus, Merdim Sonmez
Keywords(s): AA3BXX, AA3XXX, AAXXXX, Active, AXXXXX, CHANNEL, Conspicuous, Design, Guidewire, MRI, SHAFT, Single, Tip, Visibility
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing
Eeyarestatins: Novel Deubiquitination Inhibitors for the Treatment of Drug-Resistant Cancers
The ubiquitin-proteasome system has recently been recognized to play a central role in tumor biology. Bortezomib, an inhibitor of the chymotrypsin-like activity of the proteasome, has clinical activity in a variety of hematologic malignancies and is FDA approved for use in Multiple Myeloma and Mantle Cell Lymphoma. The present invention for the first...
Published: 10/28/2024   |   Inventor(s): Helena Mora-Jensen, Qiuyan Wang, Yihong Ye, Adrian Wiestner
Keywords(s): Active, Against, BBXXXX, Bortezomib, CANCER, CB5EXX, CB5XXX, CBXXXX, Cells, Chronic lymphocytic leukemia, COMPOSITION, CXXXXX, DB4AXX, DB4XXX, DBXXXX, Deubiquination, DXXXXX, Eeyarestatin, Hematologic, Highly, HIV AIDS - Therapeutics, Including, inhibitor, lymphoma, Mantle cell lymphoma, MULTIPLE MYELOMA, Proteasome, RESISTANT, That, tumor
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology
Full-Length cDNA Clone Representing the Consensus Sequence of the RNA Genome of a Human Norovirus (strain MD145-12) That Encodes Biologically Active Proteins
The invention provides for a full-length cloned cDNA copy of the RNA genome of a predominant norovirus strain (Genogroup II.4) designated MD145-12 that was associated with human gastrointestinal illness. The noroviruses, which were formerly known as "Norwalk-like" viruses are estimated to cause 23 million cases of acute gastroenteritis in the USA each...
Published: 4/8/2024   |   Inventor(s): Stanislav Sosnovtsev, Lisbeth Kim Green, Gael Belliot
Keywords(s): Active, Biological, cDNA, CLONE, CONSENSUS, DC5BXX, DCXXXX, DDXXXX, DXXXXX, ENCODES, FULL-LENGTH, Genome, Human, MD145-12, Norovirus, proteins, Respresenting, RNA, sequence, Strain, That
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Research Materials