Search Results - calcium

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Tumor Associated Calcium Signal Transducer 2 (TACSTD2)-Overexpressing Huh7.5 Cells That Are More Permissive to HCV Cell Entry and Replication Compared to the Model Huh7.5 Cell Line
Worldwide, 130-150 million individuals are chronically infected with hepatitis C virus (HCV), a major cause of liver-associated morbidity and mortality worldwide. Despite recent advances in antiviral drugs that can cure some individuals, a rapid decline of the global disease burden is hampered by remarkably high treatment costs and a high number of...
Published: 7/25/2024   |   Inventor(s): Vandana Sekhar, Patrizia Farci
Keywords(s): 2, Associated, CALCIUM, Cells, Huh7.5, Signal, TACSTD2-overexpressing, TRANSDUCER, tumor
Category(s): Collaboration Sought > Licensing
Development of genetically engineered probes for calcium sensing and manipulation
Calcium levels in cells have critical functions. Moreover, calcium signaling plays a crucial role in the control of neuronal function and plasticity. Consequently, calcium sensing dysfunction can lead to a variety of pathological conditions such as Alzheimer’s disease or neuromuscular disorders such as Dystonia. Changes in neuronal Ca2+ concentration...
Published: 3/4/2024   |   Inventor(s): Venkat Venkataraman, Anuradha Krishnan, Jeffrey Viviano, Jingyi Zhang
Keywords(s): Alzheimer's, Calcium, Genetics, Neurology, Neuromuscular
Category(s): Human Health Care > Therapeutics