Search Results - knockout

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Floxed Targeted Mouse Strain for Use in Conditional Deletion of the Irf8 Gene
IRF8, a member of interferon regulatory factor (IRF) family of transcription factors is a novel intrinsic transcriptional inhibitor of TH17-cell differentiation. TH17-cells are believed to be involved in the pathogenesis of various autoimmune/inflammatory diseases. These materials could be used to help define patterns of gene expression important for...
Published: 10/28/2024   |   Inventor(s): Herbert Morse
Keywords(s): Approved, Conditional, Deletion, Design, Development, Gene, Generate, IRF8, Knockout, Listed LPM Vepa as of 4/15/2015, Mouse, Need, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECOGNIZED, RXXXXX, Strain, Used
Category(s): Collaboration Sought > Collaboration, Application > Research Materials
CCR9 Knockout Mice
Ccr9-/- mice may be useful for studying the role of CCR9 in T lymphocyte development and migration. Mice will be distributed by The Jackson Laboratory; details about this mouse strain (Stock No. 027041) may be found at https://www.jax.org/strain/027041.
Published: 10/28/2024   |   Inventor(s): Paul Love, Shoji Uehara, Joshua Farber
Keywords(s): CCR9, Distribution, Jackson, Knockout, Laboratories, Mice, RM, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
Regulator of G Protein Signaling (RGS13) Knock-Out Mouse
RGS13, an intracellular protein in mast cells, was shown to suppress IgE-mediated anaphylactic response in mice. The RGS13-/- mouse may be used to screen compounds that inhibit mast cell degranulation.
Published: 10/28/2024   |   Inventor(s): Zhi Hui (Sherry) Xie, Kirk Druey
Keywords(s): Anaphylactic, Cells, IGE-MEDIATED, Intracellutar, Knockout, Listed LPM Maddox as of 4/15/2015, MAST, Mice, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protein, RESPONSE, RGS13, RM, RXXXXX, Suppresses, That, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
Islet Beta Cell Only M3 Muscarinic Acetylcholine Receptor Knockout Mouse
Researchers at NIH have developed islet beta cell M3 muscarinic acetylcholine receptor knockout mouse. The mice were generated by crossing floxed mouse M3 muscarinic acetylcholine receptor mice with mice in which Cre recombinase was controlled by the beta-cell specific rat insulin promoter (RIP-Cre mice).
Published: 10/28/2024   |   Inventor(s): Jurgen Wess
Keywords(s): ACETYLCHOLINE, Beta, Cell, IDXXXX, ISLET, IXXXXX, Knockout, M3, MUSCARINIC, RECEPTOR
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
Fgfr4 Knockout Mouse Model for Respiratory System Studies
FGFR4 knockout: Lung alveoli fail to develop normally in double mutant with FGFR4 and FGFR3 knockouts. The fibroblast growth factor receptor 4 (fgfr-4) gene was inactivated by targeted disruption and homozygous recombination to study its possible role in lung development. FGFR-4 is expressed in postnatal lung, and FGFR-4 null mice have no obvious abnormalities....
Published: 4/8/2024   |   Inventor(s): Chuxia Deng
Keywords(s): 4, factor, FGFR4, Fibroblast, Generation, Growth, IDXXXX, IXXXXX, Knockout, Mice, RECEPTOR
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics
Fibroblast Growth Factor Receptor 1 (Fgfr1) Conditional Knock Out Mouse
Scientists at NIDDK have developed a fibroblast growth factor receptor 1 (Fgfr1) conditional knock out mouse. Fgfr1 is a member of the Fgfr family of transmembrane protein receptors with intrinsic tyrosine kinase activity. Fgfr1 is important in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ...
Published: 10/28/2024   |   Inventor(s): Chuxia Deng
Keywords(s): 1, AC5XXX, ACXXXX, AXXXXX, Conditional, factor, FGFR1, Fibroblast, Growth, Knockout, Mice, RECEPTOR
Category(s): Collaboration Sought > Licensing
TRPC Knockout (KO) Mice and Mice with a Floxed Allele of TRPC Ion Channel Genes
TRPCs (Canonical Transient Receptor Potential Channels) are a group of non-selective cation channels that allow sodium and calcium into cells. There are seven different genes in mice that code TRPCs. The in vivo roles played by TRPCs as a whole are poorly understood and very little is known about the in vivo roles played by individual TRPCs nor the...
Published: 10/28/2024   |   Inventor(s): Joel Abramowitz, Lutz Birnbaumer
Keywords(s): ALLELE, CHANNEL, Floxed, Gene, ION, Knockout, Listed LPM Tong as of 4/15/2015, Mice, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, TRPC3, TRPC5, TRPC7, WBXXXX, WIXXXX, WJXXXX, WKXXXX, XEXXXX, YAXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Research Materials, Application > Diagnostics