Search Results - suppresses

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Regulator of G Protein Signaling (RGS13) Knock-Out Mouse
RGS13, an intracellular protein in mast cells, was shown to suppress IgE-mediated anaphylactic response in mice. The RGS13-/- mouse may be used to screen compounds that inhibit mast cell degranulation.
Published: 10/28/2024   |   Inventor(s): Zhi Hui (Sherry) Xie, Kirk Druey
Keywords(s): Anaphylactic, Cells, IGE-MEDIATED, Intracellutar, Knockout, Listed LPM Maddox as of 4/15/2015, MAST, Mice, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protein, RESPONSE, RGS13, RM, RXXXXX, Suppresses, That, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
Prevention or Treatment of Viral Infections by Inhibition of the Histone Methyltransferases EZH1/2
Herpes simplex viral infections, including herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), are exceptionally common worldwide. These viruses establish lifelong persistent infections with cycles of lytic reactivation to produce recurrent diseases including oral and genital lesions, herpetic keratitis/blindness, congenital-developmental syndromes,...
Published: 10/28/2024   |   Inventor(s): Jesse Arbuckle, Thomas Kristie
Keywords(s): DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, DEXXXX, DXXXXX, EZH1/2, HERPESVIRUS, Infection, Inhibitors, Latency, Listed LPM Fenn as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Reactivation, Suppresses, VLXXXX, WKXXXX, WNXXXX, XKXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease