Search Results - autophagy

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Incomplete Autophagy Induction for the Treatment of Cancer

SHORT DESCRIPTION This incomplete autophagy inducer triggers caspase-mediated apoptosis in cancer cells by inducing incomplete autophagy, leading to tumor reduction and improved survival. INVENTORS INVENTORS Maciej Lesniak* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery Jawad...

Published: 5/13/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Autophagy, Brain cancer, Breast cancer, Cancer/Oncology, Lung cancer, Melanoma, Repurposed Drugs, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Covalent ATG4B Inhibitors for Treatment of Cancer

NU 2025-186 INVENTORS Karl Scheidt* Weinberg College of Arts and Sciences, Department of Chemistry Claire Trudeau Shiyuan Cheng SHORT DESCRIPTION The invention introduces a novel class of peptidyl covalent reversible ketoamide inhibitors designed to target the cysteine protease ATG4B. BACKGROUND Glioblastoma (GBM) is an aggressive...

Published: 5/13/2026 | Updated: 10/28/2025 | Inventor(s):

Keywords(s): Autophagy, Brain cancer, Cancer/Oncology, GBM - Glioblastoma, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Methods for Enhancing GBM Treatment Through Inhibition of Autophagy Mediator ATG4B

NU 2019-106 INVENTORS Shi-Yuan Cheng* Feinberg School of Medicine, Department of Neurology Bo Hu Tianzhi Huang SHORT DESCRIPTION A novel autophagy inhibitor to enhance the efficiency of standard cancer treatments BACKGROUND Glioblastoma (GBM), an incurable, lethal disease, exhibits a poor 5-year survival rate. The usual treatment...

Published: 5/13/2026 | Updated: 6/1/2023 | Inventor(s):

Keywords(s): Autophagy, Brain cancer, Cancer/Oncology, GBM - Glioblastoma, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Use of beclin 1 Inhibitors, including 17-hydroxy Wortmannin, to Treat TRAIL-resistant Cancer

This technology includes the use of a beclin 1 inhibitor, 17-hydroxy Wortmannin, for the treatment of TRAIL-resistant colon cancer. TRAIL (TNF-related apoptosis-inducing ligand) binds to death receptors (DR4/DR5) and activates apoptosis in cancer cells. Multiple clinical trials have focused on promoting TRAIL-induced death but have had a lack of efficacy...

Published: 10/28/2024 | Updated: 12/6/2022 | Inventor(s): Sheng Dai, Wei Zheng

Keywords(s): 1, 17-hydroxy, Autophagy, Beclin, CANCER, Cells, COLON, Increased, Inhibitions, Overcomes, Resistance, TRAIL, VCXXXX, WIXXXX, WKXXXX, Wortmannin, XEXXXX

Category(s): TherapeuticArea > Oncology, Application > Research Materials, Application > Therapeutics

Modulating Autophagy as a Treatment for Lysosomal Storage Diseases

Researchers at NIAMS have developed a technology for treatment of lysosomal storage diseases by inhibition of autophagy. Pompe disease is an example of a genetic lysosomal storage disease caused by a reduction or absence of acid alpha-glucosidase (GAA). Patients with Pompe disease have a lysosomal buildup of glycogen in cardiac and skeletal muscle...

Published: 8/14/2024 | Updated: 12/6/2022 | Inventor(s): Cynthia Schreiner, Paul (Estate of) Plotz, Shoichi Takikita, Tao Xie, Rebecca Baum, Nina Raben

Keywords(s): Acid, A-glucosidase, Autophagy, B, Clearance, Complete, DEFICIENCY, Disabling, Disease, Enzyme, ERT, GB1XXX, GBXXXX, Genetic, GLYCOGEN, GXXXXX, IBXXXX, Inactivation, IXXXXX, Lysosomal, Model, Mouse, MUSCLE, Near, Patent Category - Biotechnology, Permits, Pompe, REPLACEMENT, SKELETAL, Storage, STORED, THERAPY, UA1XXX

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Rare/Neglected Diseases

Cancer Therapy via Simultaneous Non-apoptotic Cell Death Mechanisms

Project ID: D2018-15 Most current cancer therapies rely on agents that trigger apoptotic (programmed) cell-death pathways. During treatment, tumors can acquire mutations that diminish apoptotic responses and become chemoresistant, often accompanied by increased drug efflux and enhanced DNA repair. This resistance contributes to therapeutic failure, particularly...

Published: 4/15/2026 | Updated: 7/30/2020 | Inventor(s): Amit Tiwari, Chandrabose Karthikeyan, Haneen Amawi, Paul Erhardt, Piyush Trivedi

Keywords(s): Autophagy, Cancer, Drug-resistance, Methuosis, Non-apoptotic cell death

Category(s): Oncology

Novel Compounds in Treating Autophagy-Related Pathologies

Project IDs: D2015-09 and D2016-81 Autophagy is a self-degradation process of cellular organelles that helps defend against metabolic stress, maintain metabolic equilibrium, arbitrate cell fate decisions, and safeguard genomic stability. Deficient autophagy has been associated with over 100 diseases, and experimental enhancement of autophagy often...

Published: 4/6/2026 | Updated: 4/3/2019 | Inventor(s): Kenneth Hensley, Travis Denton

Keywords(s): ALS, Alzheimer's, Autophagy, Lanthionine Ketimine, Parkinson's

Category(s): Neuroscience