Search Results - drug-resistance

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Ferroptosis-HDAC Inhibitor Hybrids for treating cancer
Project ID: D2022-16 Background Many cancer treatments target cells and induce apoptosis, a cell death mechanism. Due to genetic instability, tumors become more heterogeneous leading to cells that avert molecular signatures that are targeted by the cancer drugs. Drug resistance remains a major impediment to the success of a cancer treatment. Combinatorial...
Published: 6/18/2024   |   Inventor(s): Liyanaaratchige Tillekeratne, Endri Karaj, Shaimaa Sindi, William Taylor
Keywords(s): Cancer, Drug-resistance, HDAC inhibitors, Histone deacetylases , Non-apoptotic cell death
Category(s): Oncology
Cancer Therapy via Simultaneous Non-apoptotic Cell Death Mechanisms
Project ID: D2018-15 Background Most of current cancer therapy employs drugs that act through apoptotic signaling pathways. However, cancer cells often acquire mutations that can diminish apoptosis and lead to chemo-resistance when coupled with increased capacity for drug efflux and DNA repair. This results in chemotherapeutic failure especially...
Published: 6/18/2024   |   Inventor(s): Amit Tiwari, Chandrabose Karthikeyan, Haneen Amawi, Paul Erhardt, Piyush Trivedi
Keywords(s): Autophagy, Cancer, Drug-resistance, Methuosis, Non-apoptotic cell death
Category(s): Oncology
Development of Novel Antibiotic Agents to Treat Drug-Resistant Microorganisms
Project ID: D2015-58 Invention Description: The expanding populations of microbes that have developed resistance to many of the available antibiotics require new drugs which can act through novel mechanisms to thwart this increasing resistance. Our technology provides the basis for development of selective drugs that can function through a novel...
Published: 5/9/2024   |   Inventor(s): Ronald Viola, Bharani Thangavelu, Pravin Bhansali
Keywords(s): Antibiotic, Antimicrobial, Drug-resistance, Enzyme, Inhibitor, Target
Category(s): Rare Disease