Search Results - drug-resistance

3 Results Sort By:
Ferroptosis-HDAC Inhibitor Hybrids for treating cancer
Project ID: D2022-16 Background Many cancer treatments target cells and induce apoptosis, a cell death mechanism. Due to genetic instability, tumors become more heterogeneous leading to cells that avert molecular signatures that are targeted by the cancer drugs. Drug resistance remains a major impediment to the success of a cancer treatment. Combinatorial...
Published: 6/18/2024   |   Inventor(s): Liyanaaratchige Tillekeratne, Endri Karaj, Shaimaa Sindi, William Taylor
Keywords(s): Cancer, Drug-resistance, HDAC inhibitors, Histone deacetylases , Non-apoptotic cell death
Category(s): Oncology
Cancer Therapy via Simultaneous Non-apoptotic Cell Death Mechanisms
Project ID: D2018-15 Background Most current cancer therapies rely on agents that trigger apoptotic (programmed) cell-death pathways. During treatment, tumors can acquire mutations that diminish apoptotic responses and become chemoresistant, often accompanied by increased drug efflux and enhanced DNA repair. This resistance contributes to therapeutic...
Published: 2/23/2026   |   Inventor(s): Amit Tiwari, Chandrabose Karthikeyan, Haneen Amawi, Paul Erhardt, Piyush Trivedi
Keywords(s): Autophagy, Cancer, Drug-resistance, Methuosis, Non-apoptotic cell death
Category(s): Oncology
Development of Novel Antibiotic Agents to Treat Drug-Resistant Microorganisms
Project ID: D2015-58 Invention Description: The expanding populations of microbes that have developed resistance to many of the available antibiotics require new drugs which can act through novel mechanisms to thwart this increasing resistance. Our technology provides the basis for development of selective drugs that can function through a novel...
Published: 5/9/2024   |   Inventor(s): Ronald Viola, Bharani Thangavelu, Pravin Bhansali
Keywords(s): Antibiotic, Antimicrobial, Drug-resistance, Enzyme, Inhibitor, Target
Category(s): Rare Disease