Search Results - antibiotic

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Novel HPPK (Bacterial Protein) Inhibitors for Use as Antibacterial Agents
Abstract: Research and development leading to the discovery of novel antibiotics has waned in recent years. At the same time, the emergence and spread of antimicrobial resistance has compounded the global danger to human health from bacterial infections.  The bacterial protein 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) is a key enzyme...
Published: 4/8/2024   |   Inventor(s): Xinhua Ji, Genbin Shi, Gary Shaw
Keywords(s): ANTIBIOTIC, Bacterial Protein, BACTERICIDAL, Biodefense, Broad Spectrum, Folate Biosynthesis, HPPK, Ji, small molecule
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Therapeutics
PSM Peptides as Vaccine Targets Against Methicillin-Resistant Staphylococcus aureus
Available for licensing and commercial development are compositions and methods for the treatment and inhibition of Methicillin-resistant Staphylococcus aureus (MRSA), a dangerous human pathogen. The invention concerns immunogenic peptides that can be used to induce protective immunity against MRSA, including phenol-soluble modulin (PSM) peptides. In...
Published: 10/28/2024   |   Inventor(s): Rong Wang, Michael Otto
Keywords(s): Against, ANTIBIOTIC, AUREUS, CA-MRSA, DB3XXX, DBXXXX, DC4XXX, DCXXXX, DXXXXX, fasciitis, Gene, GenePeptides, Immunity, Immunogenic, Methicillin-resistant, MRSA, necrotizing, necrotizing fasciitis, Peptides, PMS, PSM, Staphloccus, STAPHYLOCOCCAL, Staphylococcus, Targets, Vaccine
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease
Alteration of Albomycin for the Treatment of Bacterial Infections
Reference #: 01438 The University of South Carolina is offering licensing opportunities for Alteration of Albomycin for the Treatment of Bacterial Infections Background: There are numerous antibiotics on the market: however, resistance to almost all of these have been reported in some fashion. Invention Description: The invention proposes to alter...
Published: 11/17/2023   |   Inventor(s): Steven Fiester
Keywords(s): albomycin, antibiotic, gallium, Klebsiella pneumoniae
Category(s): Health Sciences, Biomedical and Life Sciences
Development of Novel Antibiotic Agents to Treat Drug-Resistant Microorganisms
Project ID: D2015-58 Invention Description: The expanding populations of microbes that have developed resistance to many of the available antibiotics require new drugs which can act through novel mechanisms to thwart this increasing resistance. Our technology provides the basis for development of selective drugs that can function through a novel...
Published: 5/9/2024   |   Inventor(s): Ronald Viola, Bharani Thangavelu, Pravin Bhansali
Keywords(s): Antibiotic, Antimicrobial, Drug-resistance, Enzyme, Inhibitor, Target
Category(s): Rare Disease