Search Results - bharani+thangavelu

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y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability
­Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...
Published: 9/25/2023   |   Inventor(s): Jianfeng Cai, Shibo JIANG, Lu LU, Songyi XUE, Xinling WANG, Lei WANG, Wei XU, Shuai XIA
Keywords(s): Drug Discovery, Immunology
Category(s): Technology Classifications > Medical > Biotechnology
Nature-inspired Functionally-graded UHMWPE + Kevlar Composites Achieve Extraordinarily High Strength
Nature-inspired polymers are achieved using unique processing to yield functional gradient composites with embedded Kevlar fibers exhibiting extraordinarily high strength lightweight UHMWPE materials. Background: Demand for new energy absorption materials and implantable polymeric biomaterials has increased significantly in recent years. The...
Published: 10/17/2024   |   Inventor(s): Shenqiang Ren, Lu An
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Materials and Chemicals, Technology Classifications > Nanotechnology, Technology Classifications > Engineering
Potent Compounds for the Treatment of Canavan Disease & Cancers
Project ID: D2016-55Invention Description:Elevated levels of N-acetylaspartate (NAA) is a major hallmark of Canavan disease (CD), which currently has no cure or standard course of treatment. Mutations in the aspA gene, which encodes aspartoacylase, render it unable to adequately catalyze the synthesis of NAA in CD patients. The Nat8l gene encodes aspartate...
Published: 10/29/2024   |   Inventor(s): Ronald Viola, Bharani Thangavelu, Qinzhe Wang, Vinay Mutthamsetty
Keywords(s): Canavan, Cancer, Enzyme, Inhibitor, Neurological, Target
Category(s): Rare Disease
Development of Novel Antibiotic Agents to Treat Drug-Resistant Microorganisms
Project ID: D2015-58 Invention Description: The expanding populations of microbes that have developed resistance to many of the available antibiotics require new drugs which can act through novel mechanisms to thwart this increasing resistance. Our technology provides the basis for development of selective drugs that can function through a novel...
Published: 5/9/2024   |   Inventor(s): Ronald Viola, Bharani Thangavelu, Pravin Bhansali
Keywords(s): Antibiotic, Antimicrobial, Drug-resistance, Enzyme, Inhibitor, Target
Category(s): Rare Disease
Network-Coded Multiple Access
[Licensing negotiation in progress] [Invitation for Expression of Interest - Deadline: 16 June 2016] Systems and methods include a first wireless local area network (WLAN) system that jointly exploit physical-layer network coding (PNC) and multi-user decoding (MUD) to boost system throughput. This multiple access mode is referred to as Network-Coded...
Published: 1/29/2024   |   Inventor(s): Soung Chang Liew, Lu LU, Lizhao You
Keywords(s): Network Coding, Wireless Local Area Network
Category(s): Information and Communications Technology